ERLOTINIB

(er LOE ti nib) Brand: Tarceva

What is the most significant information I must know about erlotinib?

• Do not take erlotinib if you are pregnant. It could harm the unborn child. Use effective birth control while you are taking this medicine and for at least 2 weeks after your treatment ends.

• Till taking erlotinib, speak your doctor if you have lung problems (other than lung cancer), kidney or liver malady, if you are dehydrated, or if you smoke.

• To be certain this medicine is helping your condition and not causing deleterious effects, your blood will need to be tested often. This will help your doctor determine how long to treat you with erlotinib. Visit your doctor regularly.

• Avoid exposure to sunlight or tanning beds. Erlotinib can reason skin rash, dryness, or another irritation. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Avoid using skin commodity that can reason dryness or irritation.

• Stop taking erlotinib and call your doctor at once if you have new or worsening lung problems (chest pain, dry cough with fever, wheezing, feeling short of breath), chest pain spreading to the hand or shoulder, sudden numbness or weakness, eye pain or irritation, rapid weight gain, urinating smaller than normal or not at all, severe or ongoing diarrhea or vomiting, coughing up blood, black or bloody stools, pale skin, light bruising or bleeding, mouth sores, or a severe skin rash.

• There are much another drugs that can interact with erlotinib. Speak your doctor about all medications you use. Hold a list of all your medicines and show it to any healthcare provider who treats you.

What is erlotinib?

• Erlotinib is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

• Erlotinib is used to treat non-small cell lung cancer. Erlotinib is also used in combination with another cancer medication to treat pancreatic cancer.

• Erlotinib may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking erlotinib?

• You must not take erlotinib if you are allergic to it.

• If you have any of these another conditions, you may need a doze adjustment or particular tests:

· lung or breathing problems (other than lung cancer);

· kidney disease;

· liver disease;

· if you are dehydrated; or

· if you smoke.

• FDA pregnancy category D. Do not take erlotinib if you are pregnant. It could harm the unborn child. Use effective birth control while you are taking this medicine and for at least 2 weeks after your treatment ends.

• It is not known whether erlotinib passes into breast milk or if it could harm a nursing child. You must not breast-feed while taking erlotinib.

How must I take erlotinib?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.

• Your doctor may occasionally change your doze to create certain you get the excellent results.

• Take erlotinib on an empty stomach, at least 1 hour till or 2 hours after eating.

• Do not crush an erlotinib tablet. The medication from a crushed or broken pill can be dangerous if it gets on your skin. If this occurs, wash your skin with soap and water and rinse thoroughly.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember (take only on an empty stomach). Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose symptoms may include severe diarrhea or severe skin rash.

What must I avoid while using erlotinib?

• Avoid taking an antacid within different hours till or after you take erlotinib.

• Avoid using skin commodity that can reason dryness or irritation, such as acne medications, harsh soaps or skin cleansers, or skin commodity that contain alcohol.

• Avoid smoking. It can create erlotinib smaller effective.

• Grapefruit and grapefruit juice may interact with erlotinib and lead to unwanted side effects. Discuss the use of grapefruit commodity with your doctor.

What are the possible side effects of erlotinib?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• Stop taking erlotinib and call your doctor at once if you have a serious side effect such as:

· new or worsening lung problems such as chest pain, dry cough with fever, wheezing, rapid breathing, feeling short of breath;

· chest pain spreading to the hand or shoulder, nausea, sweating, common ill feeling;

· sudden numbness or weakness, sudden severe headache, or problems with vision, speech, or balance;

· eye pain, redness, or irritation;

· confusion, mood changes, heighten thirst, urinating smaller than normal or not at all;

· swelling, rapid weight gain;

· severe or ongoing diarrhea, vomiting, or loss of appetite;

· black, bloody, or tarry stools;

· coughing up blood or vomit that looks like coffee grounds;

· pale or yellowed skin, light bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;

· white patches or sores internal your mouth or on your lips;

· fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;

· the first sign of any type of skin rash, no matter how mild; or

· nausea, upper stomach pain, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

• Smaller serious side effects may include:

· mild stomach upset, nausea, or diarrhea;

· weight loss;

· acne, dry skin; or

· weary feeling.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect erlotinib?

• Much drugs can interact with erlotinib. Adown is just a partial list. Speak your doctor if you are using:

· bosentan (Tracleer);

· conivaptan (Vaprisol);

· dexamethasone (Decadron, Hexadrol);

· imatinib (Gleevec);

· isoniazid (for treating tuberculosis);

· St. John's wort;

· steroid medication (prednisone and others);

· an antibiotic such as ciprofloxacin (Cipro), clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate), rifapentine (Priftin), or telithromycin (Ketek);

· an antidepressant such as nefazodone;

· antifungal medicine such as itraconazole (Sporanox), ketoconazole (Nizoral), or voriconazole (Vfend);

· a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton);

· a blood thinner such as warfarin (Coumadin, Jantoven);

· heart or blood pressure medicine such as nicardipine (Cardene) or quinidine (Quin-G);

· the hepatitis C medications boceprevir (Victrelis) or telaprevir (Incivek);

· HIV/AIDS medication such as atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva), etravirine (Intelence), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Kaletra, Norvir), or saquinavir (Invirase);

· medicines to treat narcolepsy, such as armodafinil (Nuvigil) or modafinil (Progivil);

· NSAIDs (non-steroidal anti-inflammatory drugs) such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others; or

· seizure medicine such as carbamazepine (Carbatrol, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), phenytoin (Dilantin), or primidone (Mysoline).

• This list is not complete and there are much another drugs that can interact with erlotinib. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor. Hold a list of all your medicines and show it to any healthcare provider who treats you.

Where can I get more information?

• Your pharmacist can provide more information about erlotinib.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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