(kriz OH ti nib) Brand: Xalkori
• Do not use crizotinib if you are pregnant. It could harm the unborn child. Use effective birth control while you are using this medicine and for at least 3 months after your treatment ends, whether you are a man or a woman.
• Till you take crizotinib, speak your doctor if you have liver or kidney malady, a heart rhythm mess, an electrolyte imbalance (such as low levels of potassium or magnesium in your blood), or a private or family history of Long QT syndrome.
• Do not stop taking this medicine without first talking to your doctor.
• There are much another drugs that can interact with crizotinib. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor. Hold a list of all your medicines and show it to any healthcare provider who treats you.
• Crizotinib is a cancer medicine that interferes with the growth and spread of cancer cells in the body.
• Crizotinib is used to treat non-small cell lung cancer.
• Crizotinib may also be used for purposes not listed in this medicine guide.
• You must not use crizotinib if you are allergic to it.
• To create certain you can safely use crizotinib, speak your doctor if you have any of these another conditions:
· liver or kidney disease;
· a heart rhythm disorder;
· a private or family history of Long QT syndrome; or
· an electrolyte imbalance (such as low levels of potassium or magnesium in your blood).
• FDA pregnancy category D. Do not use crizotinib if you are pregnant. It could harm the unborn child. Use effective birth control while you are using this medicine and for at least 3 months after your treatment ends.
• If a man fathers a baby while using this medication, the child may have birth defects. Use a condom to prevent pregnancy while you are using this medicine and for at least 3 months after your treatment ends.
• It is not known whether crizotinib passes into breast milk or if it could harm a nursing child. You must not breast-feed while you are using crizotinib.
• Till you start treatment, your doctor may perform trials to create certain crizotinib is the excellent treatment for your type of lung cancer.
• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.
• Crizotinib is generally taken twice for day. Follow your doctor's instructions.
• You may take crizotinib with or without food.
• Do not crush, chew, dissolve, or open a crizotinib capsule. Swallow it intact.
• To be certain this medication is helping your condition and is not causing deleterious effects, your blood cells and liver function may need to be tested often. Your heart function may need to be tested with an electrocardiogram (ECG or EKG). Your cancer treatments may be delayed based on the results of these trials. Do not miss any follow-up visits to your doctor.
• Do not stop taking this medicine without first talking to your doctor.
• Store in the original container at room temperature away from moisture and heat. Hold the bottle tightly closed when not in use.
• Take the missed doze as soon as you remember. Skip the missed doze if your following doze is smaller than 6 hours away. Do not take extra medication to create up the missed doze.
• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.
• Grapefruit and grapefruit juice may interact with crizotinib and lead to potentially dangerous effects. Discuss the use of grapefruit commodity with your doctor.
• This medicine may reason blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.
• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.
• Stop using crizotinib and call your doctor at once if you have a serious side effect such as:
· severe dizziness, fainting, quick or pounding heartbeats;
· vision problems such as blurred vision, heighten sensitivity of your eyes to easy, or seeing flashes of easy or "floaters";
· chest pain, dry cough or cough with mucus, wheezing, feeling short of breath;
· light bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
· fever, chills, body aches, flu symptoms, sores in your mouth and throat; or
· nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
• Smaller serious side effects may include:
· mild dizziness;
· weary feeling;
· nausea, vomiting, stomach pain, loss of appetite;
· diarrhea, constipation;
· mild rash or itching;
· cool symptoms such as stuffy nose, sneezing, sore throat;
· numbness or tingling; or
· swelling in your hands or feet.
• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.
• Much drugs can interact with crizotinib. Adown is just a partial list. Speak your doctor if you are using:
· a blood thinner such as warfarin (Coumadin, Jantoven);
· cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune) or tacrolimus (Prograf);
· dexamethasone (Cortastat, Dexasone, Solurex, DexPak);
· digoxin (digitalis, Lanoxin, Lanoxicaps);
· isoniazid (for treating tuberculosis);
· nicardipine (Cardene);
· pimozide (Orap);
· St. John's wort;
· theophylline (Elixophyllin, Theo-24, Theochron, Uniphyl);
· an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate), rifapentine (Priftin), or telithromycin (Ketek);
· an antidepressant such as citalopram (Celexa), desipramine (Norpramin), doxepin (Sinequan, Silenor), escitalopram (Lexapro), mirtazapine (Remeron), nefazodone, sertraline (Zoloft), trazodone (Desyrel, Oleptro), trimipramine (Surmontil), or venlafaxine (Effexor);
· antifungal medicine such as itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig), or voriconazole (Vfend);
· a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton);
· ergot medication such as ergotamine (Ergomar, Cafergot) or dihydroergotamine (D.H.E. 45, Migranal Nasal Spray);
· a heart rhythm medicine such as disopyramide (Norpace), procainamide (Procan, Pronestyl), or quinidine (Quin-G);
· HIV/AIDS medication such as atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva, Atripla), etravirine (Intelence), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, Kaletra), or saquinavir (Invirase); or
· seizure medicine such as carbamazepine (Carbatrol, Equetro, Tegretol), divalproex (Depakote), felbamate (Felbatol), oxcarbazepine (Trileptal), phenytoin (Dilantin), primidone (Mysoline), or valproic acid (Depakene, Stavzor).
• This list is not complete and there are much another drugs that can interact with crizotinib. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor. Hold a list of all your medicines and show it to any healthcare provider who treats you.
• Your pharmacist can provide more information about crizotinib.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
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