CINACALCET

(sin ah CAL set) Brand: Sensipar

What is the most significant information I must know about cinacalcet?

• You must not take this medicine if you are allergic to cinacalcet.

• Till you take cinacalcet, speak your doctor if you have tall blood pressure, heart malady, heart failure, a heart rhythm mess, liver malady, or a history of seizures.

• There are much another medicines that can interact with cinacalcet. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor. Hold a list of all your medicines and show it to any healthcare provider who treats you.

• Cinacalcet works excellent if you take it with food or shortly after eating a meal.

• Do not crush or interrupt a cinacalcet tablet. Swallow the pill whole.

• To be certain this medicine is helping your condition, your blood may need to be tested often. Visit your doctor regularly.

• Call your doctor at once if you have a serious side effect such as numbness or tingly feeling near your mouth, quick or slow heart course, muscle tightness or contraction, overactive reflexes, seizure, feeling short of breath, swelling, rapid weight gain, or feeling like you might pass out.

What is cinacalcet?

• Cinacalcet decreases levels of parathyroid hormone (PTH), calcium, and phosphorous in the body.

• Cinacalcet is used to treat hyperparathyroidism (overactive functioning of the parathyroid glands) in people who are on long-term dialysis for kidney disease.

• Cinacalcet is also used to lower calcium levels in people with cancer of the parathyroid gland.

• Cinacalcet may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking cinacalcet?

• You must not take this medicine if you are allergic to cinacalcet.

• To create certain you can safely take cinacalcet, speak your doctor if you have any of these another conditions:

· tall blood pressure;

· heart malady, heart failure, heart rhythm disorder;

· a history or seizures;

· low levels of calcium in your blood (hypocalcemia); or

· liver disease.

• FDA pregnancy category C. It is not known whether cinacalcet will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.

• It is not known whether cinacalcet passes into breast milk or if it could harm a nursing child. You must not breast-feed while you are taking cinacalcet.

• Do not give this medicine to a baby without a doctor's advice.

How must I take cinacalcet?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.

• Your doctor may occasionally change your doze to create certain you get the excellent results.

• Cinacalcet works excellent if you take it with food or shortly after eating a meal.

• Do not crush or interrupt a cinacalcet tablet. Swallow the pill whole.

• To be certain your calcium and phosphorous levels do not get too low, your blood will need to be tested 1 week after you start taking cinacalcet or whenever your doze is changed. You may also need blood trials on a regular basis during treatment. Do not miss any follow-up visits to your doctor.

• Store at room temperature away from moisture, easy, and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

What must I avoid while taking cinacalcet?

• Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of cinacalcet?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• Call your doctor at once if you have a serious side effect such as:

· numbness or tingly feeling near your mouth, quick or slow heart course, muscle tightness or contraction, overactive reflexes;

· seizure (convulsions);

· feeling short of breath, even with mild exertion;

· swelling, rapid weight gain; or

· feeling like you might pass out.

• Smaller serious side effects may include:

· nausea, vomiting, diarrhea;

· loss of appetite;

· muscle pain, mild chest pain;

· dizziness; or

· weakness;

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect cinacalcet?

• Much drugs can interact with cinacalcet. Adown is just a partial list. Speak your doctor if you are using:

· chloroquine (Arelan);

· conivaptan (Vaprisol);

· diclofenac (Arthrotec, Cataflam, Voltaren, Flector Patch, Solareze);

· imatinib (Gleevec);

· isoniazid (for treating tuberculosis);

· bladder medicine such as tamsulosin (Flomax) or tolterodine (Detrol);

· an antibiotic such as clarithromycin (Biaxin), dalfopristin/quinupristin (Synercid), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), or telithromycin (Ketek);

· an antidepressant such as amitriptyline (Elavil, Vanatrip), desipramine (Norpramin), duloxetine (Cymbalta), fluoxetine (Prozac), nefazodone, nortriptyline (Pamelor), paroxetine (Paxil), sertraline (Zoloft), and others

· antifungal medicine such as itraconazole (Sporanox) or ketoconazole (Nizoral);

· ADHD medicine such as atomoxetine (Strattera), dextroamphetamine (Adderall), or methylphenidate (Ritalin, Daytrana, Metadate, Concerta);

· cancer medication such as doxorubicin (Adriamycin, Doxil), lomustine (CeeNU), tamoxifen (Soltamox);

· cough medication (narcotic or over-the-counter);

· heart or blood pressure medicine such as carvedilol (Coreg), diltiazem (Cartia, Cardizem), felodipine (Plendil), flecainide (Tambocor), labetalol (Normodyne), metoprolol (Lopressor), nifedipine (Nifedical, Procardia), procainamide (Procan, Pronestyl), propafenone (Rythmol), propranolol (Inderal), verapamil (Calan, Covera, Isoptin, Verelan), and others;

· HIV/AIDS medication such as atazanavir (Reyataz), delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase), or ritonavir (Norvir);

· medication to treat psychiatric disorders, such as chlorpromazine (Thorazine), haloperidol (Haldol), promethazine (Phenergan), or thioridazine (Mellaril); or

· pain medicine such as codeine (Tylenol #3), hydrocodone (Lortab, Vicodin, Vicoprofen), oxycodone (OxyContin, Percocet), or tramadol (Ultram, Ultracet).

Where can I get more information?

• Your pharmacist can provide more information about cinacalcet.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

(67)