(boe SUE tin ib) Brand: Bosulif
• Bosutinib is used to treat a type of blood cancer called Philadelphia chromosome positive chronic myelogenous leukemia (CML).
• Do not use bosutinib if you are pregnant or breast-feeding a baby.
• Take bosutinib with food.
• Do not interrupt or crush a bosutinib tablet. The medication from a crushed or broken pill can be dangerous if it gets on your skin. Ask your doctor or pharmacist how to safely handle and dispose of a broken tablet.
• Stop using bosutinib and call your doctor at once if you have fever, light bruising or bleeding, shortness of breath, jaundice (yellowing of the skin or eyes), swelling or rapid weight gain, blood in your stools, or severe and ongoing vomiting, stomach pain, or diarrhea.
• Bosutinib interferes with the growth of some cancer cells.
• Bosutinib is used to treat a type of blood cancer called Philadelphia chromosome positive chronic myelogenous leukemia (CML).
• Bosutinib is generally given after another similar medications have been tried without success.
• Bosutinib may also be used for purposes not listed in this medicine guide.
• You must not use bosutinib if you are allergic to it.
• To create certain bosutinib is safety for you, speak your doctor if you have:
· liver disease;
· kidney disease;
· epilepsy, migraine headaches; or
· asthma, chronic obstructive pulmonary malady (COPD), or another breathing disorder.
• FDA pregnancy category D. Do not use bosutinib if you are pregnant. It could harm the unborn child. Speak your doctor right away if you become pregnant during treatment. Use effective birth control while you are using this medicine and for at least 30 days after your treatment ends.
• It is not known whether bosutinib passes into breast milk or if it could harm a nursing child. You must not breast-feed while using this medication. After you stop taking bosutinib, ask your doctor how long to wait till breast-feeding again.
• Bosutinib is generally taken once for day. Follow all directions on your prescription label. Your doctor may occasionally change your doze to create certain you get the excellent results. Do not take this medication in larger or less amounts or for longer than recommended.
• Take with food.
• Do not interrupt or crush a bosutinib tablet. The medication from a crushed or broken pill can be dangerous if it gets on your skin. If this occurs, wash your skin with soap and water. Ask your doctor or pharmacist how to safely handle and dispose of a broken tablet.
• You may need frequent medical trials at your doctor's office to be certain this medicine is not causing deleterious effects. Your cancer treatments may be delayed based on the results of these tests.
• You must not stop using bosutinib without your doctor's advice.
• Store at room temperature away from moisture and heat.
• Take the missed doze as soon as you remember. If you are more than 12 hours late, skip the missed doze. Do not take extra medication to create up the missed dose.
• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.
• Grapefruit and grapefruit juice may interact with bosutinib and lead to unwanted side effects. Discuss the use of grapefruit commodity with your doctor.
• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.
• Stop using bosutinib and call your doctor at once if you have:
· severe or ongoing nausea, vomiting, stomach pain, or diarrhea;
· black, bloody, or tarry stools, coughing up blood or vomit that looks like coffee grounds;
· fever, chills, body aches, flu symptoms, sores in your mouth and throat;
· pale skin, light bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
· upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
· swelling in your hands or foots, rapid weight gain;
· pain in your chest, on your left side, or behind your breastbone;
· pain when you breathe, quick or uneven heart course, feeling short of breath (especially when lying down);
· anxiety, sweating, wheezing, gasping for breath, cough with foamy mucus; or
· feeling weak, weary, dizzy, or light-headed.
• General side effects may include:
· headache, dizziness, weary feeling;
· mild stomach discomfort;
· joint pain, back pain;
· mild itching or rash; or
· cool symptoms such as stuffy nose, sneezing, sore throat.
• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.
• Much drugs can interact with bosutinib. Not all possible interactions are listed here. Speak your doctor about all your medications and any you start or stop using during treatment with bosutinib, especially:
· aprepitant;
· bosentan;
· cimetidine;
· conivaptan;
· cyclosporine;
· digoxin, digitalis;
· haloperidol;
· imatinib;
· modafinil;
· St. John's wort;
· an antibiotic--azithromycin, ciprofloxacin, clarithromycin, doxycycline, erythromycin, metronidazole, nafcillin, norfloxacin, rifabutin, rifampin, rifapentine, telithromycin, tetracycline;
· antifungal medication--clotrimazole, fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole;
· an antidepressant--desipramine, nefazodone, sertraline;
· heart or blood pressure medication--amiodarone, captopril, carvedilol, diltiazem, dronedarone, felodipine, lidocaine, ranolazine, nicardipine, quinidine, verapamil;
· hepatitis C medications--boceprevir, telaprevir;
· HIV/AIDS medication--atazanavir, delavirdine, fosamprenavir, efavirenz, darunavir/ritonavir, indinavir, nelfinavir, nevirapine, ritonavir, saquinavir;
· seizure medication--carbamazepine, fosphenytoin, oxcarbazepine, phenobarbital, phenytoin, primidone; or
· stomach acid reducers--dexlansoprazole, esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole.
• This list is not complete and much another drugs can interact with bosutinib. This includes prescription and over-the-counter medicines, vitamins, and herbal commodity. Give a list of all your medicines to any healthcare provider who treats you.
• Your pharmacist can provide more information about bosutinib.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
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