(a poe MOR feen) Brand: Apokyn
• You must not use apomorphine if you also taking alosetron (Lotronex), dolasetron (Anzemet), granisetron (Kytril), ondansetron (Zofran), or palonosetron (Aloxi).
• Till using apomorphine, speak your doctor if you have an electrolyte imbalance (such as low levels of potassium or magnesium in your blood), a slow heart course, low blood pressure or dizzy spells, a history of "Long QT syndrome," a history of stroke or heart onslaught, asthma, sulfite allergy, or liver or kidney disease.
• Apomorphine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
• Some people using this medication have fallen asleep during usual daytime activities such as talking, eating, or driving. You may fall asleep suddenly, even after feeling alert. If this happens to you, stop taking apomorphine and conversation with your doctor.
• You may have heighten sexual urges, unusual urges to gamble, or another intense urges while taking this medicine. Conversation with your doctor if you believe you have any intense or unusual urges while taking apomorphine.
• Apomorphine has some of the same effects as a chemical called dopamine, which occurs naturally in your body. Low levels of dopamine in the brain are associated with Parkinson's disease.
• Apomorphine is used to treat "wearing-off" episodes (muscle stiffness, loss of muscle control) in people with advanced Parkinson's disease.
• Apomorphine may also be used for another purposes not listed in this medicine guide.
• You must not use this medicine if you are allergic to apomorphine, or if you are using any of the next medications:
· alosetron (Lotronex);
· dolasetron (Anzemet);
· granisetron (Kytril);
· ondansetron (Zofran); or
· palonosetron (Aloxi).
• If you have any of these another conditions, you may need an apomorphine doze adjustment or particular tests:
· an electrolyte imbalance (such as low levels of potassium or magnesium in your blood);
· schizophrenia or similar mental illness;
· a slow heart rate;
· low blood pressure or dizzy spells;
· a private or family history of "Long QT syndrome";
· a history of stroke or heart attack;
· asthma or sulfite allergy;
· liver malady; or
· kidney disease.
• Some people using this medication have fallen asleep during usual daytime activities such as talking, eating, or driving. You may fall asleep suddenly, even after feeling alert. If this happens to you, stop taking apomorphine and conversation with your doctor.
• FDA pregnancy category C. It is not known whether apomorphine will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.
• It is not known whether apomorphine passes into breast milk or if it could harm a nursing child. You must not breast-feed while you are taking apomorphine.
• Some people taking Parkinson's malady medications have developed skin cancer (melanoma). However, people with Parkinson's malady may have a higher risk of melanoma. Conversation to your doctor about this risk and what skin symptoms to watch for. You may need to have regular skin exams.
• Never use apomorphine in larger amounts, or use it for longer than recommended by your doctor. Follow the directions on your prescription label. Speak your doctor if the medication seems to stop working as well.
• Apomorphine is injected under the skin. You may be shown how to use injections at house. Do not self-inject this medication if you or your caregivers do not fully understand how to give the injection and properly dispose of used needles and syringes.
• Do not inject apomorphine into a vein.
• Measuring your apomorphine doze correctly is extremely significant. If you use an injector pen with your apomorphine, the medicine is measured in milliliters (mL) marked on the pen. However, your predesigned doze may be in milligrams (mg). One milligram, or 1 mg, of apomorphine is equal to 0.1 mL marked on the dosing pen.
• Do not use the medication if it has changed colors, looks green or cloudy, or has particles in it. Call your doctor for a new prescription.
• Use a various seat on your stomach, hand, or thigh every time you give the injection. Your care provider will show you the excellent places on your body to inject the medicine. Do not inject into the same seat two times in a row.
• Use a disposable needle only once. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Hold this container out of the reach of children and pets.
• Apomorphine can reason severe nausea and vomiting. For this cause, your doctor may prescribe an anti-nausea medicine for you to start taking a little days till you begin using apomorphine. You may also need to hold using the anti-nausea medication throughout your treatment with apomorphine.
• If you stop using apomorphine for 7 days or longer, ask your doctor till restarting the medicine. You may need to restart with a lower dose.
• Do not stop using apomorphine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using apomorphine.
• Store at room temperature, away from heat, moisture, and light.
• Use the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not use extra medication to create up the missed dose.
• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include nausea, extreme drowsiness, or fainting.
• Apomorphine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
• Avoid getting up too quick from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
• Do not drink alcohol. It can further lower your blood pressure and may magnify determined side effects of apomorphine.
• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.
• Call your doctor at once if you have a serious side effect such as:
· nausea or vomiting that continues after taking an anti-nausea medication;
· feeling like you might pass out;
· dizziness, fainting, quick or pounding heartbeat, feeling short of breath;
· depression, confusion, hallucinations, unusual or inappropriate behavior;
· chest pain or hard feeling, pain spreading to the hand or shoulder, nausea, sweating, common ill feeling;
· slow heart course, weak pulse, fainting, slow breathing (breathing may stop);
· severe headache;
· worsening of your Parkinson symptoms;
· twitching or uncontrollable movements of your eyes, lips, tongue, person, arms, or legs; or
· penis erection that is painful or lasts 4 hours or longer.
• Smaller serious side effects may include:
· drowsiness, yawning;
· runny nose;
· swelling in your hands or feet;
· pale skin, heighten sweating;
· flushing, (warmth, redness, or tingly feeling); or
· bruising, redness, pain, itching, or hardening of your skin where the injection was given.
• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.
• Till using apomorphine, speak your doctor if you regularly use another medicines that create you sleepy (such as cool or allergy medication, sedatives, narcotic pain medication, sleeping pills, muscle relaxers, and medication for seizures, depression, or anxiety). They can add to sleepiness caused by apomorphine.
• Much drugs can interact with apomorphine. Adown is just a partial list. Speak your doctor if you are using:
· arsenic trioxide (Trisenox);
· blood pressure medications;
· metoclopramide (Reglan);
· sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra);
· an antidepressant such as amitriptylline (Elavil, Vanatrip), clomipramine (Anafranil), or desipramine (Norpramin);
· anti-malaria medications such as chloroquine (Arelan), or mefloquine (Lariam);
· an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), levofloxacin (Levaquin), moxifloxacin (Avelox), or pentamidine (NebuPent, Pentam);
· heart rhythm medication such as amiodarone (Cordarone, Pacerone), dofetilide (Tikosyn), disopyramide (Norpace), ibutilide (Corvert), procainamide (Pronestyl), propafenone (Rythmol), quinidine (Quin-G), or sotalol (Betapace);
· medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), clozapine (FazaClo, Clozaril), haloperidol (Haldol), pimozide (Orap), thioridazine (Mellaril), thiothixene (Navane), or ziprasidone (Geodon);
· migraine headache medication such as sumatriptan (Imitrex) or zolmitriptan (Zomig);
· narcotic medicine such as methadone (Dolophine, Methadose); or
· nitrate medicine, such as nitroglycerin (Nitro-Dur, Nitrolingual, Nitrostat, Transderm-Nitro, and others), isosorbide dinitrate (Dilatrate, Isordil, Isochron), or isosorbide mononitrate (Imdur, ISMO, Monoket).
• This list is not complete and another drugs may interact with apomorphine. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.
• Your doctor or pharmacist can provide more information about apomorphine.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
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