METOCLOPRAMIDE

(MET oh KLOE pra mide) Brand: Metozolv ODT, Reglan

What is the most significant information I must know about metoclopramide?

• NEVER TAKE METOCLOPRAMIDE IN LARGER AMOUNTS THAN RECOMMENDED, OR FOR LONGER THAN 12 WEEKS. Tall doses or long-term use of metoclopramide can reason a serious movement mess that may not be reversible. Symptoms of this mess include uncontrollable muscle movements of your lips, tongue, eyes, person, arms, or legs. The longer you take metoclopramide, the more likely you are to develop a serious movement mess. The risk of this side effect is higher in women, diabetics, and older adults.

• You must not take this medicine if you are allergic to metoclopramide, or if you have bleeding or blockage in your stomach or intestines, epilepsy or another seizure mess, or an adrenal gland tumor (pheochromocytoma).

• Till you take metoclopramide, speak your doctor if you have kidney or liver malady, congestive heart failure, tall blood pressure, diabetes, Parkinson's malady, or a history of depression.

• Do not drink alcohol. It can magnify some of the side effects of metoclopramide.

• There are much another medicines that can interact with metoclopramide. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor. Hold a list of all your medicines and show it to any healthcare provider who treats you.

• Stop using metoclopramide and call your doctor at once if you have tremors or uncontrolled muscle movements, fever, stiff muscles, confusion, sweating, quick or uneven heartbeats, rapid breathing, depressed mood, thoughts of suicide or hurting yourself, hallucinations, anxiety, agitation, seizure, or jaundice (yellowing of your skin or eyes).

What is metoclopramide?

• Metoclopramide increases muscle contractions in the upper digestive tract. This speeds up the course at which the stomach empties into the intestines.

• Metoclopramide is used short-term to treat heartburn caused by gastroesophageal reflux in people who have used another medications without relief of symptoms.

• Metoclopramide is also used to treat slow gastric emptying in people with diabetes (also called diabetic gastroparesis), which can reason nausea, vomiting, heartburn, loss of appetite, and a feeling of fullness after meals.

• Metoclopramide may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking metoclopramide?

• You must not take this medicine if you are allergic to metoclopramide, or if you have:

· bleeding or blockage in your stomach or intestines;

· a perforation (hole) in your stomach or intestines;

· epilepsy or another seizure mess; or

· an adrenal gland tumor (pheochromocytoma).

• To create certain you can safely take metoclopramide, speak your doctor if you have any of these another conditions:

· kidney disease;

· liver malady (especially cirrhosis);

· congestive heart failure, a heart rhythm disorder;

· tall blood pressure;

· breast cancer;

· Parkinson's disease;

· diabetes (your insulin doze may need adjusting); or

· depression or mental illness.

• FDA pregnancy category B. This medicine is not expected to be deleterious to an unborn child. Speak your doctor if you are pregnant or plan to become pregnant during treatment.

• Metoclopramide can pass into breast milk and may harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

• The metoclopramide orally disintegrating tablet (ODT) may contain phenylalanine. Conversation to your doctor till using this form of metoclopramide if you have phenylketonuria (PKU).

• Metoclopramide must not be given to a child.

How must I take metoclopramide?

• Take exactly as predesigned by your doctor. Metoclopramide is generally taken for only 4 to 12 weeks. Follow the directions on your prescription label.

• Take metoclopramide 30 minutes till eating. Metoclopramide is generally taken till meals and at bedtime. Your doctor may want you to take the medicine as needed only with meals that generally reason heartburn. Follow your doctor's instructions.

• Measure the liquid medication with a particular dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

• To take metoclopramide orally disintegrating tablet (ODT):

· Hold the tablet in its bottle or blister pack before you are ready to take the medication. Create certain your hands are dry till handling a tablet. If the tablet breaks or melts in your arm, throw it away and use a new tablet.

· Seat the tablet on your tongue. It will begin to melt right away. Do not swallow the tablet intact. Let it to melt in your mouth without chewing.

· Swallow different times as the tablet melt. You do not need to drink liquid to help the tablet melt.

• Do not take two various forms of metoclopramide (such as tablets and oral syrup) at the same time.

• Store at room temperature away from moisture and heat. Hold the bottle tightly closed when not in use.

• After you stop taking metoclopramide, you may have unpleasant withdrawal symptoms such as headache, dizziness, or nervousness. Conversation to your doctor about how to avoid withdrawal symptoms when stopping the medication.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include drowsiness, confusion, tremors or uncontrolled muscle movements in your person or neck, or seizure (convulsions).

What must I avoid while taking metoclopramide?

• Avoid drinking alcohol. It can magnify some of the side effects of metoclopramide.

• Metoclopramide may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

What are the possible side effects of metoclopramide?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Stop taking metoclopramide and call your doctor at once if you have any of these SIGNS OF A SERIOUS MOVEMENT Mess, which may occur within the first 2 days of treatment:

· tremors or shaking in your arms or legs;

· uncontrolled muscle movements in your person (chewing, lip smacking, frowning, tongue movement, blinking or eye movement); or

· any new or unusual muscle movements you can't control.

• Stop taking metoclopramide and call your doctor at once if you have any of these another serious side effects:

· slow or jerky muscle movements, problems with balance or walking;

· mask-like appearance in your face;

· very stiff (rigid) muscles, tall fever, sweating, confusion, quick or uneven heartbeats, tremors, feeling like you might pass out;

· depressed mood, thoughts of suicide or hurting yourself;

· hallucinations, anxiety, agitation, jittery feeling, trouble staying still;

· swelling, feeling short of breath, rapid weight gain;

· jaundice (yellowing of your skin or eyes); or

· seizure (convulsions).

• Smaller serious side effects may include:

· feeling restless, drowsy, weary, or dizzy;

· headache, sleep problems (insomnia);

· nausea, vomiting, diarrhea;

· breast tenderness or swelling;

· changes in your menstrual periods; or

· urinating more than usual.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect metoclopramide?

• Till using metoclopramide, speak your doctor if you regularly use another medicines that create you sleepy (such as cool or allergy medication, sedatives, narcotic pain medication, sleeping pills, muscle relaxers, and medication for seizures, depression, or anxiety). They can add to sleepiness caused by metoclopramide.

• Speak your doctor about all another medications you use, especially:

· acetaminophen (Tylenol);

· cyclosporine (Gengraf, Neoral, Sandimmune);

· digoxin (digitalis, Lanoxin);

· glycopyrrolate (Robinul);

· insulin;

· levodopa (Larodopa, Atamet, Parcopa, Sinemet);

· mepenzolate (Cantil);

· tetracycline (Ala-Tet, Brodspec, Panmycin, Sumycin, Tetracap);

· atropine (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm-Scop);

· bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol), or solifenacin (Vesicare);

· blood pressure medications;

· bronchodilators such as ipratroprium (Atrovent) or tiotropium (Spiriva);

· irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Anaspaz, Cystospaz, Levsin), or propantheline (Pro-Banthine);

· an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate); or

· medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), clozapine (Clozaril, FazaClo), haloperidol (Haldol), olanzapine (Zyprexa, Symbyax), prochlorperazine (Compazine), risperidone (Risperdal), thiothixene (Navane), and others.

• This list is not complete and there are much another drugs that can interact with metoclopramide. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor. Hold a list of all your medicines and show it to any healthcare provider who treats you.

Where can I get more information?

• Your pharmacist can provide more information about metoclopramide.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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