GLYBURIDE

(GLYE bue ride) Brand: DiaBeta, Glynase PresTab, Micronase

What is the most significant information I must know about glyburide?

• You must not use this medicine if you are allergic to glyburide, if you are being treated with bosentan (Tracleer), if you have type 1 diabetes, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

• Till taking glyburide, speak your doctor if you are allergic to sulfa drugs, if you have been using insulin or chlorpropamide (Diabinese), or if you have hemolytic anemia (a lack of red blood cells), an enzyme deficiency (G6PD), a nerve mess, liver malady, or kidney disease.

• Take care not to allow your blood sugar get too low. Low blood sugar (hypoglycemia) can occur if you skip a meal, exercice too long, drink alcohol, or are under stress. Symptoms include headache, famine, weakness, sweating, tremor, irritability, or trouble concentrating. Carry heavy candy or glucose tablets with you in case you have low blood sugar. Another sugar sources include orange juice and milk. Be certain your family and close friends know how to help you in an emergency.

What is glyburide?

• Glyburide is an oral diabetes medication that helps control blood sugar levels.

• Glyburide is used to treat type 2 diabetes.

• This medicine is not for treating type 1 diabetes.

• Glyburide may also be used for another purposes not listed in this medicine guide.

What must I discuss with my health care provider till taking glyburide?

• You must not use this medicine if you are allergic to glyburide, or:

· if you are being treated with bosentan (Tracleer);

· if you have type 1 diabetes; or

· if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

• To create certain you can safely take glyburide, speak your doctor if you have any of these another conditions:

· hemolytic anemia (a lack of red blood cells);

· an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD);

· a nerve mess affecting bodily functions;

· liver or kidney disease;

· if you are allergic to sulfa drugs; or

· if you have been using insulin or taking chlorpropamide (Diabinese).

• Determined oral diabetes medications may magnify your risk of serious heart problems. However, not treating your diabetes can hurt your heart and another organs. Conversation to your doctor about the risks and benefits of treating your diabetes with glyburide.

• FDA pregnancy category C. It is not known whether glyburide will harm an unborn child. Similar diabetes medications have caused severe hypoglycemia in newborn babies whose mothers had used the medicine around the time of delivery. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.

• It is not known whether glyburide passes into breast milk or if it could harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

• Older adults may be more likely to have low blood sugar while taking glyburide.

How must I take glyburide?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your doze to create certain you get the excellent results.

• Take glyburide with your first meal of the day, unless your doctor tells you otherwise.

• Your blood sugar will need to be checked often, and you may need another blood trials at your doctor's office. Visit your doctor regularly.

• Know the signs of low blood sugar (hypoglycemia) and how to recognize them: headache, famine, weakness, sweating, tremor, irritability, or trouble concentrating.

• Always hold a source of sugar accessible in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. If you have severe hypoglycemia and can't ate or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon abnormal injection kit and speak you how to give the injection.

• Also watch for signs of blood sugar that is too tall (hyperglycemia). These symptoms include heighten thirst, heighten urination, famine, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss.

• Check your blood sugar carefully during a time of stress or diseases, if you travel, exercice more than normal, drink alcohol, or skip meals. These things can affect your glucose levels and your doze needs may also change.

• Your doctor may want you to stop taking glyburide for a short time if you become ill, have a fever or infection, or if you have surgery or a medical emergency.

• Ask your doctor how to adjust your glyburide doze if needed. Do not change your medicine doze or schedule without your doctor's advice.

• If there are any changes in the brand, power, or type of glyburide you use, your dosage needs may change. Always check your refills to create certain you have received the correct brand and type of medication predesigned by your doctor.

• Store at room temperature, protected from moisture, heat, and light.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222. A glyburide overdose can reason life-threatening hypoglycemia.

• Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).

What must I avoid while taking glyburide?

• Avoid drinking alcohol. It lowers blood sugar and may interfere with your diabetes treatment.

• Avoid exposure to sunlight or tanning beds. Glyburide can create you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

What are the possible side effects of glyburide?

• Stop using glyburide and get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Stop taking this medicine and call your doctor at once if you have any of these serious side effects:

· nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

· pale skin, confusion or weakness;

· light bruising or bleeding, purple or red pinpoint spots under your skin; or

· headache, trouble concentrating, memory problems, feeling unsteady, hallucinations, fainting, seizure, shallow breathing or breathing that stops.

• Smaller serious side effects may include:

· mild nausea, heartburn, feeling full;

· joint or muscle pain;

· blurred vision; or

· mild itching or skin rash.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect glyburide?

• Speak your doctor about all another medications you use, especially:

· a blood thinner such as warfarin (Coumadin, Jantoven);

· cyclosporine (Gengraf, Neoral, Sandimmune);

· disopyramide (Norpace);

· fluconazole (Diflucan), ketoconazole (Nizoral);

· fluoxetine (Prozac);

· rifampin (Rifadin, Rimactane, Rifater);

· an ACE inhibitor such as enalapril (Vasotec), lisinopril (Prinivil, Zestril), ramipril (Altace), and others; or

· an antibiotic such as ciprofloxacin (Cipro), levofloxacin (Levaquin), and others.

• Using determined medicines can create it harder for you to speak when you have low blood sugar. Speak your doctor if you use any of the following:

· albuterol (Proventil, Ventolin);

· clonidine (Catapres);

· reserpine; or

· beta-blockers such as atenolol (Tenormin), carvedilol (Coreg), metoprolol (Lopressor, Toprol), propranolol (Inderal, InnoPran), and others.

• You may be more likely to have hyperglycemia (high blood sugar) if you take glyburide with:

· isoniazid;

· diuretics (water pills);

· steroids (prednisone and others);

· phenothiazines (Compazine and others);

· thyroid medication (Synthroid and others);

· birth control pills and another hormones;

· heart or blood pressure medications (Cartia, Cardizem, Nifedical, Covera, Verelan, and others);

· niacin (Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others);

· seizure medicines (Dilantin and others); and

· diet pills or medicines to treat asthma, colds or allergies.

• You may be more likely to have hypoglycemia (low blood sugar) if you take glyburide with:

· clarithromycin (Biaxin);

· exenatide (Byetta);

· probenecid (Benemid);

· heart or blood pressure medicine (Accupril, Altace, Lotensin, Prinivil, Vasotec, Zestril, and others);

· some nonsteroidal anti-inflammatory drugs (NSAIDs);

· aspirin or another salicylates (including Pepto-Bismol);

· sulfa drugs (Bactrim, Gantanol, Septra, and others);

· a monoamine oxidase inhibitor (MAOI); and

· another oral diabetes medications, especially acarbose (Precose), metformin (Glucophage), miglitol (Glyset), pioglitazone (Actos), or rosiglitazone (Avandia).

• These lists are not complete and there are much another medicines that can magnify or decrease the effects of glyburide on lowering your blood sugar. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about glyburide.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

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