GLIPIZIDE

(GLIP i zide) Brand: GlipiZIDE XL, Glucotrol, Glucotrol XL

What is the most significant information I must know about glipizide?

• Do not use this medicine if you are allergic to glipizide, or if you are in a state of diabetic ketoacidosis. Call your doctor for treatment with insulin.

• Till taking glipizide, speak your doctor if you have kidney or liver malady, chronic diarrhea or a blockage in your intestines, glucose-6-phosphate dehydrogenase deficiency (G6PD), a mess of your pituitary or adrenal glands, a history of heart malady, or if you are malnourished.

• Take care not to allow your blood sugar get too low. Low blood sugar (hypoglycemia) can occur if you skip a meal, exercice too long, drink alcohol, or are under stress. Symptoms include headache, famine, weakness, sweating, tremors, irritability, or trouble concentrating. Carry heavy candy or glucose tablets with you in case you have low blood sugar. Another sugar sources include orange juice and milk. Be certain your family and close friends know how to help you in an emergency.

• Also watch for signs of blood sugar that is too tall (hyperglycemia). These symptoms include heighten thirst, heighten urination, famine, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss. Your blood sugar will need to be checked often, and you may need to adjust your glipizide dose.

• Glipizide is only part of a complete program of treatment that may also include diet, exercice, weight control, and testing your blood sugar. Follow your diet, medicine, and exercice routines very closely. Changing any of these factors can affect your blood sugar levels.

What is glipizide?

• Glipizide is an oral diabetes medication that helps control blood sugar levels. This medicine helps your pancreas manufacture insulin.

• Glipizide is used together with diet and exercice to treat type 2 diabetes.

• Glipizide may also be used for another purposes not listed in this medicine guide.

What must I discuss with my doctor till taking glipizide?

• Do not use this medicine if you are allergic to glipizide, or if you are in a state of diabetic ketoacidosis. Call your doctor for treatment with insulin.

• To create certain you can safely take glipizide, speak your doctor if you have any of these another conditions:

· liver disease;

· kidney disease;

· chronic diarrhea or a blockage in your intestines;

· an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD);

· a mess of your pituitary or adrenal glands;

· a history of heart malady; or

· if you are malnourished.

• Determined oral diabetes medications may magnify your risk of serious heart problems. However, not treating your diabetes can hurt your heart and another organs. Conversation to your doctor about the risks and benefits of treating your diabetes with glipizide.

• FDA pregnancy category C. It is not known whether glipizide will harm an unborn child. Similar diabetes medications have caused severe hypoglycemia in newborn babies whose mothers had used the medicine around the time of delivery. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.

• It is not known whether glipizide passes into breast milk or if it could be deleterious to a nursing child. Do not take glipizide without telling your doctor if you are breast-feeding a baby.

How must I take glipizide?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your doze to create certain you get the excellent results.

• Take glipizide 30 minutes till a meal. If you take glipizide once daily, take it 30 minutes till breakfast.

• Glipizide extended-release (Glucotrol XL) must be taken with breakfast.

• Do not crush, chew, or interrupt an extended-release tablet. Swallow it intact. Breaking the pill may reason too many of the drug to be released at one time.

• Your blood sugar will need to be checked often, and you may need another blood trials at your doctor's office. Visit your doctor regularly.

• Know the signs of low blood sugar (hypoglycemia) and how to recognize them: headache, famine, weakness, sweating, tremors, irritability, or trouble concentrating.

• Always hold a source of sugar accessible in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. If you have severe hypoglycemia and can't ate or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon abnormal injection kit and speak you how to give the injection.

• Check your blood sugar carefully during a time of stress or diseases, if you travel, exercice more than normal, drink alcohol, or skip meals. These things can affect your glucose levels and your doze needs may also change.

• Your doctor may want you to stop taking glipizide for a short time if you become ill, have a fever or infection, or if you have surgery or a medical emergency.

• Ask your doctor how to adjust your glipizide doze if needed. Do not change your medicine doze or schedule without your doctor's advice.

• Some forms of glipizide are made with a shell that is not absorbed or melted in the body. Part of the tablet shell may appear in your stool. This is a usual side effect and will not create the medicine smaller effective.

• Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

• Take the missed doze 30 minutes till your following meal, then return to your regular schedule. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

• Use glipizide regularly to get the most benefit. Get your prescription refilled till you run out of medication completely.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222. A glipizide overdose can reason life-threatening hypoglycemia.

• Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).

What must I avoid while taking glipizide?

• Avoid drinking alcohol. It lowers blood sugar and may interfere with your diabetes treatment.

What are the possible side effects of glipizide?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Stop taking glipizide and call your doctor at once if you have a serious side effect such as:

· light bruising or bleeding (nosebleeds, bleeding gums), feeling weary or short of breath, rapid heart rate;

· nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

· pale skin, fever, confusion; or

· throbbing headache, severe nausea and vomiting, quick or pounding heartbeats, sweating or thirst, feeling like you might pass out.

• Smaller serious side effects may include:

· mild nausea;

· diarrhea, constipation;

· dizziness, drowsiness; or

· skin rash, redness, or itching.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect glipizide?

• You may be more likely to have hyperglycemia (high blood sugar) if you are taking glipizide with another drugs that raise blood sugar, such as:

· isoniazid;

· diuretics (water pills);

· steroids (prednisone and others);

· phenothiazines (Compazine and others);

· thyroid medication (Synthroid and others);

· birth control pills and another hormones;

· seizure medicines (Dilantin and others);

· niacin (Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others);

· diet pills, medicines to treat asthma, colds or allergies; and

· heart or blood pressure medicine such as diltiazem (Cartia, Cardizem), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan), and others.

• You may be more likely to have hypoglycemia (low blood sugar) if you are taking glipizide with another drugs that lower blood sugar, such as:

· nonsteroidal anti-inflammatory drugs (NSAIDs);

· aspirin or another salicylates (including Pepto-Bismol);

· sulfa drugs (Bactrim and others);

· a monoamine oxidase inhibitor (MAOI);

· beta-blockers (Tenormin and others);

· exenatide (Byetta);

· fluconazole (Diflucan);

· probenecid (Benemid);

· a blood thinner (warfarin, Coumadin, Jantoven, and others); and

· another oral diabetes medications, especially acarbose (Precose), metformin (Glucophage), miglitol (Glyset), pioglitazone (Actos), or rosiglitazone (Avandia).

• These lists are not complete and there are much another medicines that can magnify or decrease the effects of glipizide on lowering your blood sugar. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about glipizide.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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