ASPIRIN, CHLORPHENIRAMINE, AND PHENYLEPHRINE

(ASP rin, KLOR fen IR a meen, and FEN il EFF rin) Brand: Alka-Seltzer Plus Cool Formula

What is the most significant information I must know about this medicine?

• Aspirin must not be given to a baby or teenager who has a fever, especially if the baby also has flu symptoms or chicken pox. Aspirin can reason a serious and sometimes fatal condition called Reye's syndrome in children. Do not give this medicine to a baby younger than 4 years old. Always ask a doctor till giving a cough or cool medication to a child. Death can occur from the misuse of cough and cool medicines in very young children.

• You must not use this medicine if you have severe constipation, a blockage in your stomach or intestines, or if you are unable to urinate.

• Do not use this medication if you have untreated or uncontrolled illness such as glaucoma, asthma or COPD, tall blood pressure, heart malady, coronary artery malady, or overactive thyroid.

• Do not use this medication if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the recent 14 days. A dangerous drug interaction could occur, leading to serious side effects.

• Aspirin may reason serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning while you are taking this medicine, especially in older adults. Call your doctor at once if you have symptoms of stomach bleeding such as black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

What is aspirin, chlorpheniramine, and phenylephrine?

• Aspirin is in a group of drugs called salicylates (sa-LIS-il-ates). It works by reducing substances in the body that reason pain, fever, and inflammation.

• Chlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can manufacture symptoms of sneezing, itching, watery eyes, and runny nose.

• Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can reason nasal congestion (stuffy nose).

• The combination of aspirin, chlorpheniramine, and phenylephrine is used to treat fever, body aches, runny or stuffy nose, sneezing, itching, watery eyes, and sinus congestion caused by allergies, the general cool, or the flu.

• Aspirin, chlorpheniramine, and phenylephrine may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking this medicine?

• You must not use this medicine if you have severe constipation, a blockage in your stomach or intestines, stomach or intestinal bleeding, a bleeding mess such as hemophilia, or if you are unable to urinate.

• Do not use this medication if you have untreated or uncontrolled illness such as glaucoma, asthma or COPD, tall blood pressure, heart malady, coronary artery malady, or overactive thyroid.

• Ask a doctor or pharmacist if it is safety for you to take this medicine if you have:

· heartburn, stomach pain, indigestion, ulcer, or another stomach problems;

· a colostomy or ileostomy;

· diabetes;

· liver or kidney disease;

· epilepsy or another seizure disorder;

· cough with mucus, or cough caused by emphysema, smoking, or chronic bronchitis;

· enlarged prostate or urination problems;

· pheochromocytoma (an adrenal gland tumor);

· if you are on a low-salt diet; or

· if you take potassium (Cytra, Epiklor, K-Lyte, K-Phos, Kaon, Klor-Con, Polycitra, Urocit-K).

• FDA pregnancy category C. Aspirin may be deleterious to an unborn baby's heart, and may also reduce birth weight or have another dangerous effects. Do not use this medication without medical advice if you are pregnant.

• It is not known whether aspirin, chlorpheniramine, and phenylephrine passes into breast milk or if it could harm a nursing child. Antihistamines and decongestants may also slow breast milk manufacture. Do not use this medication without medical advice if you are breast-feeding a baby.

How must I take this medicine?

• Use exactly as directed on the label, or as predesigned by your doctor. Do not use in larger or less amounts or for longer than recommended. This medication is generally taken only for a short time before your symptoms clear up.

• Do not take for longer than 7 days in a row. Conversation with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a sore throat that lasts longer than 2 days, or a sore throat with a fever and headache, nausea, vomiting, or skin rash.

• Drop the effervescent tablets into a glass of water (at least 4 ounces, or one-half cup). Stir this mixture and drink all of it right away.

• If you need surgery or medical trials, speak the surgeon or doctor onward of time if you have taken this medication within the past little days.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Since this medication is taken when needed, you may not be on a dosing schedule. If you are taking the medicine regularly, take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose symptoms may include severe forms of some of the side effects listed in this medicine guide.

What must I avoid while taking this medicine?

• This medication may reason blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

• Drinking alcohol can magnify determined side effects of this medicine. Alcohol may also magnify your risk of stomach bleeding while you are taking aspirin.

• Ask a doctor or pharmacist till using any another cool, allergy, cough, or sleep medication. Aspirin (sometimes abbreviated as ASA), antihistamines, and decongestants are contained in much combination medicines. Taking determined commodity together can reason you to get too many of a determined drug. Check the label to see if a medication contains an aspirin, ASA, an antihistamine, or a decongestant.

What are the possible side effects of this medicine?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Stop using this medication and call your doctor at once if you have a serious side effect such as:

· bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

· quick, slow, or uneven heart course, tremor, seizure (convulsions);

· ringing in your ears, severe headache, mood changes, severe dizziness or anxiety, hallucinations, feeling like you might pass out;

· redness or swelling, new cool or flu symptoms;

· feeling short of breath, urinating smaller than normal or not at all; or

· dangerously tall blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, uneven heartbeats, seizure).

• Smaller serious side effects may include:

· mild headache, mild dizziness, drowsiness;

· dry mouth, nose, or throat;

· heartburn, nausea, diarrhea, constipation, upset stomach;

· feeling nervous, restless, or irritable; or

· sleep problems (insomnia).

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect aspirin, chlorpheniramine, and phenylephrine?

• Ask your doctor till using an antidepressant such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Rapiflux, Sarafem, Selfemra, Symbyax), fluvoxamine (Luvox), paroxetine (Paxil, Pexeva), sertraline (Zoloft), trazodone (Desyrel, Oleptro), or vilazodone (Viibryd). Taking any of these medicines with aspirin may reason you to bruise or bleed easily.

• Till using this medicine, speak your doctor if you regularly use another medicines that create you sleepy (such as allergy medication, sedatives, narcotic pain medication, sleeping pills, muscle relaxers, and medication for seizures, depression, or anxiety). They can add to sleepiness caused by chlorpheniramine.

• Ask a doctor or pharmacist if it is safety for you to use aspirin, chlorpheniramine, and phenylephrine if you are also using any of the next drugs:

· topiramate (Topamax);

· zonisamide (Zonegran);

· a blood thinner such as warfarin (Coumadin, Jantoven);

· gout medicine such as probenecid (Benemid);

· phenobarbital (Solfoton) or another barbiturates;

· anti-nausea medications such as belladonna (Donnatal), dimenhydrinate (Dramamine), droperidol (Inapsine), methscopolamine (Pamine), or scopolamine (Transderm Scop);

· bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), solifenacin (Vesicare), tolterodine (Detrol), or Urogesic Blue;

· bronchodilators such as ipratropium (Atrovent) or tiotropium (Spiriva);

· irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Hyomax), or propantheline (Pro Banthine);

· a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others; or

· ulcer medication such as glycopyrrolate (Robinul) or mepenzolate (Cantil).

• This list is not complete and another drugs may interact with aspirin, chlorpheniramine, and phenylephrine. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about aspirin, chlorpheniramine, and phenylephrine.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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