AMITRIPTYLINE AND CHLORDIAZEPOXIDE

(a mi TRIP ti leen and klor paint az e POX ide) Brand: Limbitrol, Limbitrol DS

What is the most significant information I must know about amitriptyline and chlordiazepoxide?

• You must not use this medicine if you have recently had a heart onslaught, or if you are allergic to amitriptyline (Elavil), chlordiazepoxide (Librium), or to Valium, Xanax, or any another benzodiazepine.

• Do not use this medicine if you have taken an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) in the recent 14 days.

• Amitriptyline and chlordiazepoxide can harm an unborn child or reason birth defects. Do not use amitriptyline and chlordiazepoxide if you are pregnant.

• You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

• Message any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

• Do not drink alcohol while taking this medication.

What is amitriptyline and chlordiazepoxide?

• Amitriptyline is a tricyclic (try-SYE-klik) antidepressants. Amitriptyline affects chemicals in the brain that may become unbalanced.

• Chlordiazepoxide is in a group of drugs called benzodiazepines (ben-zoe-dye-AZE-eh-peens). Chlordiazepoxide affects chemicals in the brain that may become unbalanced and reason anxiety.

• The combination of amitriptyline and chlordiazepoxide is used to treat depression and anxiety.

• Amitriptyline and chlordiazepoxide may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking amitriptyline and chlordiazepoxide?

• You must not use this medicine if you have recently had a heart onslaught, or if you are allergic to amitriptyline (Elavil), chlordiazepoxide (Librium), or to any benzodiazepine such as alprazolam (Xanax), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), or oxazepam (Serax).

• To create certain you can safely take amitriptyline and chlordiazepoxide, speak your doctor if you have any of these another conditions:

· epilepsy or seizure disorder;

· a thyroid disorder;

· kidney or liver disease;

· heart disease;

· bipolar mess (manic-depression);

· a history of suicidal thoughts or behavior;

· history of drug or alcohol addiction;

· narrow-angle glaucoma; or

· problems with urination.

• You may have thoughts about suicide while taking an antidepressant, especially if you are younger than 24 years old. Speak your doctor if you have worsening depression or suicidal thoughts during the first different weeks of treatment, or whenever your doze is changed.

• Your family or another caregivers must also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

• This medicine can harm an unborn child or reason birth defects. Do not use amitriptyline and chlordiazepoxide if you are pregnant. Speak your doctor right away if you become pregnant during treatment. Use effective birth control while you are using this medication.

• It is not known whether this medicine passes into breast milk or if it could harm a nursing child. You must not breast-feed while taking amitriptyline and chlordiazepoxide.

• The sedative effects of this medicine may recent longer in older adults. Accidental falls are general in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury while you are taking amitriptyline and chlordiazepoxide.

How must I take amitriptyline and chlordiazepoxide?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your doze to create certain you get the excellent results.

• It may take up to 4 weeks till your symptoms improve. Hold using the medicine as directed and speak your doctor if your symptoms do not improve after 4 weeks of treatment.

• If you need surgery, speak the surgeon onward of time that you are using amitriptyline and chlordiazepoxide. You may need to stop using the medication for a short time.

• If you use this medicine long-term, your blood will need to be tested on a regular basis. Do not miss any scheduled appointments.

• Do not stop using amitriptyline and chlordiazepoxide suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using the medicine.

• Amitriptyline and chlordiazepoxide may be habit-forming and must be used only by the face it was predesigned for. Never share this medicine with other face, especially somebody with a history of drug abuse or addiction. Hold the medicine in a seat where others can't get to it.

• Store at room temperature away from moisture and heat.

• Hold track of the amount of medication used from every new bottle. Benzodiazepines are drugs of abuse and you must be aware if anyone is using your medication improperly or without a prescription.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222. An overdose of amitriptyline and chlordiazepoxide can be fatal, especially if taken with alcohol.

• Overdose symptoms may include irregular heartbeats, extreme drowsiness, overactive reflexes, stiff muscles, dilated pupils, vomiting, feeling hot or cool, feeling like you might pass out, or seizure (convulsions).

What must I avoid while taking amitriptyline and chlordiazepoxide?

• Do not drink alcohol. Amitriptyline and chlordiazepoxide can magnify the effects of alcohol, which could be dangerous.

• This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

What are the possible side effects of amitriptyline and chlordiazepoxide?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• Call your doctor at once if you have a serious side effect such as:

· confusion, hallucinations, unusual thoughts or behavior;

· feeling light-headed, fainting;

· seizure (convulsions);

· weak or shallow breathing;

· chest pain or hard feeling, pain spreading to the hand or shoulder, nausea, sweating, common ill feeling; or

· sudden numbness or weakness (especially on one side of the body), headache, confusion, problems with vision, speech, or balance.

• Smaller serious side effects may include:

· dry mouth, stuffy nose, blurred vision;

· dizziness, drowsiness;

· feeling restless or tired;

· constipation, bloating, loss of appetite;

· strange dreams or nightmares; or

· decreased sex drive, impotence, or difficulty having an orgasm.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect amitriptyline and chlordiazepoxide?

• Till taking this medication, tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), or sertraline (Zoloft).

• Cool or allergy medication, sedatives, narcotic pain medication, sleeping pills, muscle relaxers, and medication for seizures or anxiety can add to sleepiness caused by amitriptyline and chlordiazepoxide. Speak your doctor if you regularly use any of these medicines, or any another antidepressant.

• Much drugs can interact with amitriptyline and chlordiazepoxide. Adown is just a partial list. Speak your doctor if you are using:

· celecoxib (Celebrex);

· cimetidine (Tagamet);

· darifenacin (Enablex);

· ropinirole (Requip);

· terbinafine (Lamisil);

· ADHD medications (Adderall, Ritalin, Strattera);

· anti-malaria medicine such as chloroquine (Arelan), hydroxychloroquine (Plaquenil, Quinaprox), or quinine (Qualaquin);

· cancer medications such as gefitinib (Iressa), imatinib (Gleevec), or nilotinib (Tasigna);

· a heart rhythm medicine such as amiodarone (Cordarone, Pacerone), flecainide (Tambocor), propafenone (Rythmol), or quinidine (Quin-G);

· HIV medicine such as delavirdine (Rescriptor) or ritonavir (Norvir);

· medication to treat or prevent nausea and vomiting, such as metoclopramide (Reglan) or promethazine (Pentazine, Phenergan);

· medication to treat psychiatric disorders, such as aripiprazole (Abilify), chlorpromazine (Thorazine), fluphenazine (Permitil), haloperidol (Haldol), perphenazine (Trilafon), or thioridazine (Mellaril);

· a narcotic such as methadone (Methadose, Dolophine) or propoxyphene (Darvon, Darvocet).

• This list is not complete and there are much another drugs that can interact with amitriptyline and chlordiazepoxide. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor. Hold a list of all your medicines and show it to any healthcare provider who treats you.

Where can I get more information?

• Your pharmacist can provide more information about amitriptyline and chlordiazepoxide.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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