TOREMIFENE

(tor EH mih feen) Brand: Fareston

What is the most significant information I must know about toremifene?

• Do not use toremifene if you are pregnant. It could harm the unborn child.

• You must not use toremifene if you are allergic to it, or if you have a history of Long QT syndrome, or an uncontrolled electrolyte imbalance (low levels of potassium or magnesium in your blood).

• Till you take toremifene, speak your doctor if you have endometrial hyperplasia (overgrowth of cells lining the uterus), bone cancer, or if you have ever had a blood clot.

• Taking toremifene may magnify your risk of developing endometrial hyperplasia, a condition that may lead to cancer of the uterus. Conversation to your doctor about your individual risk.

• Stop using toremifene and call your doctor at once if you have symptoms of a serious heart rhythm mess (severe dizziness, fainting, quick or pounding heartbeats) or signs of tall levels of calcium in your blood (nausea, vomiting, stomach pain, loss of appetite, constipation, heighten thirst or urination, muscle pain or weakness, joint pain, confusion, and feeling weary or restless).

What is toremifene?

• Toremifene blocks estrogen from achievement cancer cells. Determined types of breast cancer require estrogen to grow.

• Toremifene is used to slow the growth of metastatic breast cancer (cancer that has spread from the original tumor). Unlike chemotherapy, toremifene does not actually destroy cancer cells.

• Toremifene may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking toremifene?

• You must not use toremifene if you are allergic to it, or if you have:

· a history of Long QT syndrome; or

· an uncontrolled electrolyte imbalance (low levels of potassium or magnesium in your blood).

• To create certain you can safely take toremifene, speak your doctor if you have any of these another conditions:

· endometrial hyperplasia (overgrowth of cells lining the uterus);

· bone cancer; or

· if you have ever had a blood clot.

• FDA pregnancy category D. Do not use toremifene if you are pregnant. It could harm the unborn child. Use effective birth control if you are not past menopause, and speak your doctor if you become pregnant during treatment.

• It is not known whether toremifene passes into breast milk or if it could harm a nursing child. You must not breast-feed while you are using toremifene.

• Taking toremifene may magnify your risk of developing endometrial hyperplasia, a condition that may lead to cancer of the uterus. Conversation to your doctor about your individual risk.

How must I take toremifene?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.

• Toremifene is generally taken once a day. Follow your doctor's instructions.

• You may take toremifene with or without food. Take the medication at the same time every day.

• To be certain this medication is not causing deleterious effects, your blood will need to be tested often. Your liver function may also need to be tested. Visit your doctor regularly.

• Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose symptoms may include severe forms of some of the side effects listed in this medicine guide.

What must I avoid while taking toremifene?

• This medication can pass into body fluids (including urine, feces, vomit, semen, vaginal fluid). For at least 48 hours after you receive a doze, avoid allowing your body fluids to come into contact with your hands or another surfaces. Patients and caregivers must wear rubber gloves while cleaning up body fluids, handling contaminated trash or laundry or changing diapers. Wash hands till and after removing gloves. Wash soiled clothing and linens apart from another laundry.

• Body fluids must not be handled by a woman who is pregnant or who may become pregnant. Use condoms during sexual activity to avoid exposure to body fluids.

• Grapefruit and grapefruit juice may interact with toremifene and lead to potentially dangerous effects. Discuss the use of grapefruit commodity with your doctor.

What are the possible side effects of toremifene?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• Stop using toremifene and call your doctor at once if you have a serious side effect such as:

· severe dizziness, fainting, quick or pounding heartbeats, seizure (convulsions);

· nausea, vomiting, stomach pain, loss of appetite, constipation, heighten thirst or urination, muscle pain or weakness, joint pain, confusion, and feeling weary or restless;

· light bruising, unusual bleeding, purple or red pinpoint spots under your skin;

· vaginal bleeding or discharge;

· chest pain or hard feeling, pain spreading to the hand or shoulder, nausea, sweating, common ill feeling;

· sudden numbness or weakness, especially on one side of the body;

· chest pain, sudden cough, wheezing, rapid breathing, coughing up blood;

· pain, swelling, warmth, or redness in one or both legs;

· blurred vision, eye pain, or seeing halos near lights;

· jaundice (yellowing of the skin or eyes);

· tremor; or

· loss of movement in any part of your body.

• Smaller serious side effects may include:

· sweating, hot flashes;

· mild nausea, constipation;

· dizziness, spinning sensation;

· depressed mood;

· swelling in your hands or feet;

· itching, skin discoloration; or

· hair loss.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect toremifene?

• Speak your doctor about all another medicines you use, especially:

· arsenic trioxide;

· isoniazid (for treating tuberculosis);

· lithium;

· St. John's wort;

· tacrolimus;

· vitamin or mineral supplements that contain calcium or vitamin D;

· warfarin;

· an antibiotic such as clarithromycin, erythromycin, levofloxacin, ofloxacin, rifabutin, rifampin, telithromycin and others;

· an antidepressant such as amitriptylline, venlafaxine, nefazodone and others;

· antifungal medicine such as itraconazole, ketoconazole, voriconazole and others;

· seizure medication such as carbamazepine, clonazepam, phenobarbital or phenytoin;

· a diuretic (water pill) such as chlorothiazide, hydrochlorothiazide, chlorthalidone, indapamide, metolazone and others;

· heart or blood pressure medicine such as diltiazem, nicardipine, verapamil and others;

· heart rhythm medication such as amiodarone, dofetilide, disopyramide, ibutilide, procainamide, quinidine, sotalol and others;

· HIV/AIDS medication such as atazanavir, indinavir, nelfinavir, saquinavir, ritonavir and others;

· medication to prevent or treat nausea and vomiting such as granisetron or ondansetron;

· medicines to treat psychiatric disorders, such as haloperidol, thioridazine and others;

· migraine headache medication such as sumatriptan or zolmitriptan; or

· narcotic medicine such as methadone.

• This list is not complete and there are much another drugs that can interact with toremifene. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor. Hold a list of all your medicines and show it to any healthcare provider who treats you.

Where can I get more information?

• Your pharmacist can provide more information about toremifene.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.