(loe PIN a vir and ri TOE na veer) Brand: Kaletra
• You must not use this medicine if you have ever had a severe allergic reaction to lopinavir or ritonavir.
• Some medicines can interact with Kaletra and must not be used at the same time, especially: alfuzosin, cisapride, lovastatin, simvastatin, St. John's wort, pimozide, midazolam, triazolam, rifampin, sildenafil (Revatio for pulmonary arterial hypertension), or an ergot medication (ergotamine, dihydroergotamine, methylergonovine).
• Lopinavir and ritonavir are antiviral medications that prevent human immunodeficiency virus (HIV) cells from multiplying in your body
• Lopinavir and ritonavir (Kaletra) is a combination medication used to treat HIV, which causes the acquired immunodeficiency syndrome (AIDS). This medication is not a cure for HIV or AIDS.
• Lopinavir and ritonavir may also be used for purposes not listed in this medicine guide.
• You must not use this medicine if you have ever had a severe allergic reaction to lopinavir or ritonavir.
• Some medicines can reason unwanted or dangerous effects when used with Kaletra. Your doctor may need to change your treatment plan if you use any of the next drugs:
· alfuzosin;
· cisapride;
· pimozide;
· rifampin;
· sildenafil (Revatio for pulmonary arterial hypertension);
· St. John's wort; or
· an ergot medication (ergotamine, dihydroergotamine, methylergonovine).
• To create certain Kaletra is safety for you, speak your doctor if you have:
· liver malady (especially hepatitis B or C);
· heart malady or a heart rhythm disorder;
· a private or family history of Long QT Syndrome;
· pancreas problems;
· diabetes;
· low levels of potassium in your blood;
· a bleeding mess such as hemophilia;
· tall cholesterol or triglycerides; or
· if you have ever used a protease inhibitor in the past.
• FDA pregnancy category C. It is not known whether this medicine will harm an unborn child. HIV can be passed to your child if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection.
• Kaletra can create birth control pills or patches smaller effective. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking Kaletra.
• Women with HIV or AIDS must not breast-feed a child. Even if your child is born without HIV, the virus may be passed to the child in your breast milk.
• Do not give this medicine to a baby younger than 14 days old without medical advice. Premature infants must not receive the medicine before it has been 14 days after their original due date.
• Follow all directions on your prescription label, especially when giving the medication to a child. Do not take this medication in larger or less amounts or for longer than recommended.
• If a baby is taking this medicine, speak your doctor if the baby has any changes in weight. Kaletra doses are based on weight in children.
• Do not crush, chew, or interrupt a Kaletra tablet. Swallow the pill intact.
• Kaletra tablets can be taken with or without food.
• Kaletra liquid must be taken with food. Measure liquid medication with a particular dose-measuring spoon or medication cup. If you do not have a dose-measuring device, ask your pharmacist for one.
• While using Kaletra, you may need frequent blood trials at your doctor's office.
• Use Kaletra regularly to get the most benefit. Get your prescription refilled till you run out of medication completely.
• HIV/AIDS is generally treated with a combination of drugs. Use all medications as directed by your doctor. Read the medicine manual or patient instructions provided with every medicine. Do not change your doses or medicine schedule without your doctor's advice. Each face with HIV or AIDS must stay under the care of a doctor.
• Store Kaletra liquid in the refrigerator or at room temperature. If you store the liquid at room temperature you should use it within 60 days.
• Store the tablets at room temperature, away from heat and moisture. Hold the pills in their original container with the cap tightly closed.
• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.
• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Kaletra oral liquid could be fatal to a child.
• If you take Kaletra liquid and you also take didanosine (Videx), take the didanosine at least 1 hour till or 2 hours after you take Kaletra liquid.
• Kaletra liquid contains alcohol. Avoid drinking alcohol while using this medication.
• Taking this medicine will not prevent you from passing HIV to another people. Do not have unprotected sex or share razors or toothbrushes. Conversation with your doctor about safety ways to prevent HIV transmission during sex. Sharing drug or medication needles is never safety, even for a healthy person.
• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.
• Stop taking this medicine and call your doctor at once if you have:
· headache with chest pain and severe dizziness, fainting, quick or pounding heartbeats;
· severe pain in your upper stomach spreading to your back, nausea and vomiting;
· itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
· tall blood sugar (increased thirst, heighten urination);
· penis erection that is painful or lasts 4 hours or longer (if you take Kaletra with erectile dysfunction medication);
· diarrhea, unexplained weight loss, menstrual changes, impotence, loss of interest in sex;
· swelling in your neck or throat (enlarged thyroid);
· muscle weakness, weary feeling, joint or muscle pain, feeling short of breath;
· problems with walking, breathing, speech, swallowing, or eye movement;
· weakness or prickly feeling in your fingers or toes, severe lower back pain, loss of bladder or bowel control; or
· severe skin reaction -- fever, sore throat, swelling in your person or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the person or upper body) and causes blistering and peeling.
• General side effects may include:
· mild nausea, upset stomach;
· headache, weakness;
· mild stomach pain; or
· changes in the shape or location of body thick (especially in your arms, legs, person, neck, breasts, and waist).
• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.
• Much drugs can interact with Kaletra. Not all possible interactions are listed here. Speak your doctor about all your medications and any you start or stop using during treatment with Kaletra, especially:
· atovaquone;
· bosentan;
· colchicine;
· disulfiram (Antabuse);
· lamotrigine;
· salmeterol with or without fluticasone;
· an antibiotic--clarithromycin, metronidazole, rifabutin;
· an antidepressant--bupropion, trazodone;
· antifungal medication--itraconazole, ketoconazole, voriconazole;
· a blood thinner such as rivaroxaban, warfarin, Coumadin;
· cancer medications;
· cholesterol medicine--atorvastatin, rosuvastatin;
· medicines for pulmonary arterial hypertension or erectile dysfunction--avanafil, sildenafil (Viagra), tadalafil, vardenafil;
· heart or blood pressure medication such as amiodarone, felodipine, lidocaine, nicardipine, nifedipine, quinidine;
· the hepatitis C medications boceprevir or telaprevir;
· medicines to prevent organ transplant rejection;
· narcotic medicine--fentanyl, methadone;
· another HIV or AIDS medications, including efavirenz, nevirapine, nelfinavir;
· seizure medicine--carbamazepine, phenobarbital, phenytoin, valproic acid; or
· steroid medication such as budesonide, dexamethasone, fluticasone, prednisone.
• This list is not complete and much another drugs can interact with Kaletra. This includes prescription and over-the-counter medicines, vitamins, and herbal commodity. Give a list of all your medicines to any healthcare provider who treats you.
• Your pharmacist can provide more information about lopinavir and ritonavir.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
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