LAMOTRIGINE

(la MOE tri jeen) Brand: LaMICtal, LaMICtal ODT, LaMICtal ODT Patient Titration Kit (Blue), LaMICtal ODT Patient Titration Kit (Green), LaMICtal ODT Patient Titration Kit (Orange), LaMICtal Starter Kit (Blue), LaMICtal Starter Kit (Green), LaMICtal Starter Kit (Orange), LaMICtal XR, LaMICtal XR Patient Titration Kit (Blue), LaMICtal XR Patient Titration Kit (Green), LaMICtal XR Patient Titration Kit (Orange)

What is the most significant information I must know about lamotrigine?

• Till taking lamotrigine, speak your doctor if you have kidney or liver malady, a history of depression or suicidal thoughts, or if you are allergic to another seizure medications.

• Lamotrigine may reason severe or life-threatening skin rash, especially in children and in people who take too tall of a doze at the start of treatment with lamotrigine. Serious skin rash may also be more likely to occur if you are taking lamotrigine together with valproic acid (Depakene) or divalproex (Depakote).

• Seek abnormal medical attention if you have: fever, sore throat, swelling in your person or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the person or upper body) and causes blistering and peeling.

• You may have thoughts about suicide while taking this medicine. Your doctor will need to check you at regular visits. Message any new or worsening symptoms to your doctor, such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.

• Do not stop taking lamotrigine without first talking to your doctor, even if you feel beautiful. You may have heighten seizures if you stop using lamotrigine suddenly.

• Contact your doctor if your seizures get worse or you have them more often while taking lamotrigine.

• Taking this medicine during early pregnancy can magnify the risk of the child being born with cleft lip or cleft palate. Speak your doctor if you are pregnant or if you become pregnant during treatment.

What is lamotrigine?

• Lamotrigine is an anti-epileptic medicine, also called an anticonvulsant.

• Lamotrigine is used either alone or in combination with another medications to treat epileptic seizures in adults and children. Lamotrigine is also used to delay mood episodes in adults with bipolar mess (manic depression).

• The immediate-release form of lamotrigine (Lamictal, Lamictal ODT) can be used in children as young as 2 years old when it is given as part of a combination of seizure medications. However, this form must not be used as a single medicine in a baby or teenager who is younger than 16 years old.

• The extended-release form of lamotrigine (Lamictal XR) is for use only in adults and children who are at least 13 years old.

• Lamotrigine may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking lamotrigine?

• You must not take lamotrigine if you are allergic to it.

• To create certain you can safely take lamotrigine, speak your doctor if you have any of these another conditions:

· kidney or liver disease;

· a history of depression or suicidal thoughts or actions; or

· if you are allergic to another seizure medications.

• You may have thoughts about suicide while taking this medicine. Speak your doctor if you have new or worsening depression or suicidal thoughts during the first different months of treatment, or whenever your doze is changed.

• Your family or another caregivers must also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits. Do not miss any scheduled appointments.

• FDA pregnancy category C. It is not known whether lamotrigine will harm an unborn child. Taking this medicine during early pregnancy can magnify the risk of the child being born with cleft lip or cleft palate. Speak your doctor if you are pregnant or plan to become pregnant while taking lamotrigine.

• Birth control pills can create lamotrigine smaller effective, resulting in heighten seizures. Tell your doctor if you start or stop using birth control pills while you are taking lamotrigine. Your lamotrigine doze may need to be changed.

• Speak your doctor if you plan to stop taking birth control pills.

• Lamotrigine can pass into breast milk and may harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

How must I take lamotrigine?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Taking too many lamotrigine at the start of treatment may magnify your risk of a severe life-threatening skin rash. Follow the directions on your prescription label.

• Your doctor may occasionally change your doze over different weeks or months to create certain you get the excellent results. Take only the amount predesigned by your doctor whenever your doze is changed.

• To create certain you are taking the right doze of lamotrigine, your blood may need to be tested often. Visit your doctor regularly.

• Extended-release lamotrigine (Lamictal XR) may be used for various conditions than immediate-release lamotrigine is used for. Always check your refills to create certain you have received the correct size, color, and shape of tablet. Ask the pharmacist if you have any questions about the medication you receive at the pharmacy.

• If you are switching to lamotrigine from other anticonvulsant medicine, carefully follow your doctor's instructions about timing and dosage when switching from one drug to another.

• Do not crush, chew, or interrupt a regular lamotrigine tablet. Swallow it intact.

• To take the orally disintegrating tablet (Lamictal ODT), seat the tablet on your tongue and move it near in your mouth. Do not swallow the tablet intact. Let it to dissolve in your mouth without chewing. Swallow different times as the tablet dissolves. If desired, you may drink liquid to help swallow the dissolved tablet.

• To take the chewable dispersible tablet, you may either swallow it intact with a glass of water, or chew it first and then swallow it. You may also seat the tablet into 1 teaspoon of water or diluted fruit juice and let it to disperse in the liquid for about 1 minute. Gently swirl the liquid and then swallow all of the mixture right away. Do not save it for later use.

• Do not stop taking lamotrigine without first talking to your doctor, even if you feel beautiful. You may have heighten seizures if you stop using lamotrigine suddenly. You may need to use smaller and smaller till you stop the medicine completely.

• Wear a medical alert tag or carry an ID card stating that you take lamotrigine. Any medical care provider who treats you must know that you take seizure medication.

• Use lamotrigine regularly to get the most benefit. Get your prescription refilled till you run out of medication completely.

• Store at room temperature away from easy and moisture.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose symptoms may include blurred vision, problems with coordination, heighten seizures, feeling light-headed, or fainting.

What must I avoid while taking lamotrigine?

• Lamotrigine may reason blurred vision or impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

What are the possible side effects of lamotrigine?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; fever; swollen glands; painful sores in or near your eyes or mouth; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Message any new or worsening symptoms to your doctor, such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.

• Lamotrigine may reason severe or life-threatening skin rash, especially in children and in people who take too tall of a doze at the start of treatment with lamotrigine. Serious skin rash may also be more likely to occur if you are taking lamotrigine together with valproic acid (Depakene) or divalproex (Depakote). Seek abnormal medical attention if you have a fever, sore throat, swelling in your person or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the person or upper body) and causes blistering and peeling.

• If you have to stop taking lamotrigine because of a serious skin rash, you may not be able to take it again in the future.

• Call your doctor at once if you have any of these another serious side effects:

· the first sign of any skin rash, no matter how mild;

· fever, swollen glands, body aches, flu symptoms, headache, neck stiffness, heighten sensitivity to light;

· light bruising or bleeding, severe tingling, numbness, pain, muscle weakness;

· upper stomach pain, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes);

· chest pain, irregular heart rhythm, feeling short of breath;

· confusion, nausea and vomiting, swelling, rapid weight gain, urinating smaller than normal or not at all;

· pale skin, feeling light-headed or short of breath, rapid heart course, trouble concentrating; or

· heighten seizures or worsening of your bipolar disorder.

• Smaller serious side effects may include:

· tremors, dizziness, weary feeling;

· blurred vision, double vision;

· loss of coordination;

· dry mouth, mild nausea, stomach pain, upset stomach;

· changes in your menstrual periods;

· back pain;

· sleep problems (insomnia); or

· runny nose, sore throat.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect lamotrigine?

• Speak your doctor about all another medicines you use, especially:

· hormonal forms of birth control (pills, injections, implants, or skin patches);

· carbamazepine (Carbatrol, Equetro, Tegretol);

· divalproex (Depakote);

· oxcarbazepine (Trileptal);

· phenobarbital (Solfoton);

· primidone (Mysoline);

· phenytoin (Dilantin);

· rifampin (Rifadin, Rifater, Rifamate, Rimactane); or

· valproic acid (Depakene, Stavzor).

• This list is not complete and another drugs may interact with lamotrigine. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about lamotrigine.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.