IVACAFTOR
(EYE va KAF tor) Brand: Kalydeco
What is the most significant information I must know about ivacaftor?
• You must not use ivacaftor if you are allergic to it.
• Till you take ivacaftor, speak your doctor if you have liver or kidney malady.
• Ivacaftor must be taken with a food that contains thick, such as butter, peanut butter, eggs, cheese pizza. Follow your doctor's instructions very carefully.
• Grapefruit, grapefruit juice, and Seville oranges may interact with ivacaftor and lead to unwanted effects. Discuss the use of grapefruit and orange commodity with your doctor.
• To be certain this medicine is not causing deleterious effects, your liver function will need to be checked with frequent blood trials. Visit your doctor regularly.
• There are much another drugs that can interact with ivacaftor. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor. Hold a list of all your medicines and show it to any healthcare provider who treats you.
What is ivacaftor?
• Ivacaftor is used to treat cystic fibrosis in adults and children who are at least 6 years old.
• Ivacaftor is for use only in patients with a specific gene mutation related to cystic fibrosis. Till you take ivacaftor, you may need a medical test to create certain you have this gene mutation.
• Ivacaftor may also be used for purposes not listed in this medicine guide.
What must I discuss with my healthcare provider till taking ivacaftor?
• You must not use ivacaftor if you are allergic to it.
• To create certain you can safely use ivacaftor, speak your doctor if you have any of these another conditions:
· liver malady; or
· kidney disease.
• FDA pregnancy category B. Ivacaftor is not expected to harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant during treatment.
• It is not known whether ivacaftor passes into breast milk or if it could harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.
How must I take ivacaftor?
• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.
• Ivacaftor is generally taken once each 12 hours with a food that contains thick, such as butter, peanut butter, eggs, cheese pizza. Follow your doctor's instructions.
• To be certain this medicine is not causing deleterious effects, your liver function will need to be checked with frequent blood trials. Visit your doctor regularly.
• Store at room temperature away from moisture and heat.
What happens if I miss a dose?
• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.
What happens if I overdose?
• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.
• Overdose symptoms may include severe forms of some of the side effects listed in this medicine guide.
What must I avoid while taking ivacaftor?
• Grapefruit, grapefruit juice, and Seville oranges may interact with ivacaftor and lead to unwanted effects. Discuss the use of grapefruit and orange commodity with your doctor.
• This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
What are the possible side effects of ivacaftor?
• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.
• Call your doctor at once if you have a serious side effect such as:
· severe stomach pain;
· chest pain, wheezing, feeling short of breath;
· nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
· low blood sugar (headache, famine, weakness, sweating, confusion, irritability, dizziness, quick heart course, or feeling jittery).
• Smaller serious side effects may include:
· headache;
· nausea, diarrhea, stomach pain;
· dizziness;
· acne or mild rash;
· joint or muscle pain; or
· cool symptoms such as stuffy nose, sneezing, sore throat.
• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.
What another drugs will affect ivacaftor?
• Speak your doctor about all another medicines you use, especially:
· bosentan (Tracleer);
· conivaptan (Vaprisol);
· dexamethasone (Cortastat, Dexasone, Solurex, DexPak);
· imatinib (Gleevec);
· isoniazid (for treating tuberculosis);
· midazolam (Versed);
· nefazodone;
· St. John's wort;
· an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate), rifapentine (Priftin), or telithromycin (Ketek);
· antifungal medicine such as fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig), posaconazole (Noxafil), or voriconazole (Vfend);
· a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton);
· heart or blood pressure medicine such as digoxin (Lanoxin, digitalis), nicardipine (Cardene), or quinidine (Quin-G);
· the hepatitis C medications boceprevir (Victrelis) or telaprevir (Incivek);
· HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva, Atripla), etravirine (Intelence), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, Kaletra), or saquinavir (Invirase);
· medicines used to prevent organ transplant rejection, such as cyclosporine (Gengraf, Neoral, Sandimmune) or tacrolimus (Prograf).
· medicines to treat narcolepsy, such as armodafinil (Nuvigil) or modafinil (Progivil); or
· seizure medicine such as carbamazepine (Carbatrol, Equetro, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), phenytoin (Dilantin), or primidone (Mysoline).
• There may be another drugs that can interact with ivacaftor. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.
Where can I get more information?
• Your pharmacist can provide more information about ivacaftor.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
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