(pom a LID oh mide) Brand: Pomalyst
• Never use pomalidomide if you are pregnant. Even one doze of pomalidomide can reason severe, life-threatening birth defects or death of a child if the mother or the father is taking this medicine at the time of conception or during pregnancy.
• For Women: If you have not had a hysterectomy, you will be required to use two forms of birth control beginning 4 weeks till you start taking pomalidomide and ending 4 weeks after you stop taking it. You should also have a negative pregnancy test at 10 to 14 days till treatment and again at 24 hours till.
• Pomalidomide is accessible only under a particular program called Pomalyst REMS. You should be registered in the program and sign documents stating that you understand the dangers of this medicine and that you agree to use birth control measures as required by the program.
• Pomalidomide may reason blood clots. Stop using pomalidomide and call your doctor at once if you have symptoms such as chest pain, wheezing, coughing up blood, or if you have pain, swelling, warmth, or redness in one or both legs.
• Pomalidomide affects the immune system. It promotes immune responses to help slow tumor growth.
• Pomalidomide is used to treat multiple myeloma (cancer resulting from a progressive blood disease). Pomalidomide is generally given after at least two another medications have been tried without success.
• Pomalidomide is accessible only from a certified pharmacy under a particular program called Pomalyst REMS. Your doctor should be registered in the program in order to prescribe pomalidomide for you. You should be registered in the program and sign documents stating that you understand the dangers of this medicine and that you agree to use birth control measures as required by the program.
• Pomalidomide may also be used for purposes not listed in this medicine guide.
• Pomalidomide can reason severe, life-threatening birth defects or death of a child if the mother or the father is taking this medicine at the time of conception or during pregnancy. Even one doze of pomalidomide can reason major birth defects of the baby's arms and legs, bones, ears, eyes, person, and heart. Never use pomalidomide if you are pregnant. Speak your doctor right away if your period is late while using the medication.
• For Women: If you have not had a hysterectomy, you will be required to use two forms of birth control beginning 4 weeks till you start taking pomalidomide and ending 4 weeks after you stop taking it. Even women with fertility problems are required to use birth control while taking this medicine. You should also have a negative pregnancy test at 10 to 14 days till treatment and again at 24 hours till. While you are taking pomalidomide, you will have a pregnancy test each 4 weeks.
• The birth control method you use should be proven highly effective, such as birth control pills, an intrauterine device (IUD), a tubal ligation, or a sexual partner's vasectomy. The extra form of birth control you use should be a barrier method such as a latex condom, a diaphragm, or a cervical cap.
• Stop using pomalidomide and call your doctor at once if you quit using birth control, if your period is late, or if you think you might be pregnant.
• For Men: If a man fathers a child while using pomalidomide, the child may have birth defects. Use a condom to prevent pregnancy during your treatment, and for up to 28 days after your treatment ends. You should agree in writing to always use latex condoms when having sex with a woman who is able to get pregnant, even if you have had a vasectomy. Contact your doctor if you have had unprotected sex, even once, or if you think your female sexual partner may be pregnant.
• To create certain you can safely take pomalidomide, speak your doctor if you have any of these another conditions:
· liver disease;
· kidney malady; or
· if you smoke (smoking may create pomalidomide smaller effective).
• Using pomalidomide may magnify your risk of developing another types of cancer, such as leukemia or lymphoma. Conversation with your doctor about your specific risk.
• It is not known whether pomalidomide passes into breast milk or if it could harm a nursing child. You must not breast-feed while using this medicine.
• Pomalidomide is generally taken once for day. Follow all directions on your prescription label. Do not take this medication in larger or less amounts or for longer than recommended.
• Take the medication at the same time every day.
• Take pomalidomide on an empty stomach, at least 2 hours till or 2 hours after a meal.
• Take every doze with a full glass of water. Swallow the capsule whole.
• Do not open the pomalidomide capsule. The medication from internal the capsule can be dangerous if it gets in your eyes, mouth, or nose, or on your skin. If this occurs, wash your skin with soap and water or rinse your eyes with water. Ask your doctor or pharmacist how to safely handle and dispose of a broken capsule.
• Never give pomalidomide to other face, even if he or she has the same mess for which you are being treated.
• While using pomalidomide, you may need frequent blood tests.
• Store at room temperature away from moisture and heat.
• Take the missed doze as soon as you remember. If you are more than 12 hours late, skip the missed doze. Do not take extra medication to create up the missed dose.
• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.
• Do not donate blood or sperm while you are using pomalidomide.
• This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
• This medication can pass into body fluids (including urine, feces, vomit, semen, vaginal fluid). For at least 48 hours after you receive a doze, avoid allowing your body fluids to come into contact with your hands or another surfaces. Patients and caregivers must wear rubber gloves while cleaning up body fluids, handling contaminated trash or laundry or changing diapers. Wash hands till and after removing gloves. Wash soiled clothing and linens apart from another laundry.
• Body fluids must not be handled by a woman who is pregnant or who may become pregnant. Use condoms during sexual activity to avoid exposure to body fluids.
• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.
• Call your doctor at once if you have:
· fever, swollen gums, painful mouth sores, pain when swallowing, skin sores, cool or flu symptoms, cough, trouble breathing;
· light bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
· pale skin, feeling light-headed or short of breath, rapid heart course, trouble concentrating;
· stabbing chest pain, wheezing, cough with yellow or green mucus;
· numbness or tingly feeling;
· chest pain, sudden cough, wheezing, rapid breathing, coughing up blood;
· pain, swelling, warmth, or redness in one or both legs; or
· swelling in your hands or feet.
• General side effects may include:
· dizziness, confusion;
· feeling weak or tired;
· loss of appetite, nausea, diarrhea, constipation;
· mild rash; or
· back pain, joint pain, muscle pain or weakness.
• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.
• Taking pomalidomide with another drugs that reason dizziness or confusion can worsen these effects. Ask your doctor till taking pomalidomide with a sleeping pill, narcotic pain medication, muscle relaxer, or medication for anxiety, depression, or seizures.
• Much drugs can interact with pomalidomide. Not all possible interactions are listed here. Speak your doctor about all your medications and any you start or stop using during treatment with pomalidomide, especially:
· bosentan;
· cyclosporine;
· imatinib;
· isoniazid;
· nefazodone;
· St. John's wort;
· an antibiotic--azithromycin, clarithromycin, erythromycin, telithromycin;
· antifungal medication--itraconazole, ketoconazole, posaconazole, voriconazole;
· heart medication--amiodarone, captopril, carvedilol, diltiazem, dronedarone, felodipine, nicardipine, quinidine, ranolazine, verapamil;
· hepatitis C medications--boceprevir, telaprevir;
· HIV/AIDS medication--atazanavir, delavirdine, efavirenz, fosamprenavir, indinavir, nelfinavir, nevirapine, ritonavir, saquinavir, tipranavir;
· seizure medication--carbamazepine, fosphenytoin, oxcarbazepine, phenobarbital, phenytoin, primidone; or
· tuberculosis medication--rifabutin, rifampin, rifapentine.
• This list is not complete and much another drugs can interact with pomalidomide. This includes prescription and over-the-counter medicines, vitamins, and herbal commodity. Give a list of all your medicines to any healthcare provider who treats you.
• Your pharmacist can provide more information about pomalidomide.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
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