SORAFENIB

(sor a FEN ib) Brand: NexAVAR

What is the most significant information I must know about sorafenib?

• You must not use sorafenib if you have squamous cell lung cancer and you are being treated with carboplatin (Paraplatin) and paclitaxel (Onxol, Taxol, Abraxane).

• Sorafenib can reason heart problems. Stop taking this medication and call your doctor at once if you have chest pain and severe dizziness, fainting, sweating, or feeling short of breath.

• Sorafenib can also reason severe bleeding. Call your doctor if you have blood in your urine or stools, emergency vaginal bleeding, severe stomach pain, coughing up blood, or any bleeding that will not stop.

What is sorafenib?

• Sorafenib is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

• Sorafenib is used to treat a type of kidney cancer called advanced renal cell carcinoma. It is also used to treat liver cancer.

• Sorafenib may also be used for purposes not listed in this medicine guide.

What must I discuss with my health care provider till taking sorafenib?

• You must not use sorafenib if you are allergic to it, or if you have squamous cell lung cancer and you are being treated with carboplatin (Paraplatin) and paclitaxel (Onxol, Taxol, Abraxane).

• To create certain sorafenib is safety for you, speak your doctor if you have:

· kidney or liver problems another than cancer;

· lung cancer;

· a bleeding or blood clotting mess such as hemophilia;

· tall blood pressure (hypertension), heart malady, slow heartbeats, congestive heart failure, chest pain;

· a private or family history of Long QT syndrome;

· a history of stroke or heart onslaught; or

· any allergies.

• FDA pregnancy category D. Do not use sorafenib if you are pregnant. It could harm the unborn child.

• Use birth control to prevent pregnancy while you are receiving sorafenib, whether you are a man or a woman. Speak your doctor right away if a pregnancy occurs while either parent is taking this medicine. Hold using birth control for at least 2 weeks after your treatment ends.

• It is not known whether sorafenib passes into breast milk or if it could harm a nursing child. You must not breast-feed while using this medicine.

How must I take sorafenib?

• Sorafenib is generally taken 2 times for day. Follow all directions on your prescription label. Do not take this medication in larger or less amounts or for longer than recommended.

• Take sorafenib on an empty stomach, at least 1 hour till or 2 hours after eating.

• Do not crush, chew, or interrupt a sorafenib tablet. Swallow it intact with water.

• Your blood pressure will need to be checked often.

• If you need surgery or dental work, speak the surgeon or dentist onward of time that you are using sorafenib. You may need to stop using the medication for a short time.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember, but at least 2 hours since your recent meal. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

What must I avoid while taking sorafenib?

• This medication can pass into body fluids (including urine, feces, vomit, semen, vaginal fluid). For at least 48 hours after you receive a doze, avoid allowing your body fluids to come into contact with your hands or another surfaces. Patients and caregivers must wear rubber gloves while cleaning up body fluids, handling contaminated trash or laundry or changing diapers. Wash hands till and after removing gloves. Wash soiled clothing and linens apart from another laundry.

• Body fluids must not be handled by a woman who is pregnant or who may become pregnant. Use condoms during sexual activity to avoid exposure to body fluids.

What are the possible side effects of sorafenib?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• Stop using sorafenib and call your doctor at once if you have:

· mouth sores;

· blood in your urine or stools, coughing up blood or vomit that looks like coffee grounds;

· hard menstrual periods, light bruising, unusual bleeding, or any bleeding that will not stop;

· pale skin, feeling light-headed, rapid heart course, trouble concentrating;

· dry cough, wheezing;

· chest pain and severe dizziness, fainting, sweating, swelling, rapid weight gain, feeling short of breath (even with mild exertion);

· rash, blisters, oozing, or severe pain in the palms of your hands or the soles of your feet;

· upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

· sudden weight loss, heighten appetite, trouble sleeping, heighten bowel movements, feeling hot, feeling nervous or anxious, swelling in your neck (goiter);

· dangerously tall blood pressure (severe headache, blurred vision, buzzing in your ears, confusion, uneven heartbeats, seizure); or

· severe skin reaction -- fever, sore throat, swelling in your person or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the person or upper body) and causes blistering and peeling.

• General side effects may include:

· weary feeling;

· vomiting, diarrhea, mild stomach pain;

· mild itching or rash; or

· weight loss, thinning hair.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect sorafenib?

• Speak your doctor about all another cancer medicines you use, especially cisplatin, cyclophosphamide, docetaxel, doxorubicin, fluorouracil, gemcitabine, irinotecan, paclitaxel, or tamoxifen.

• Much drugs can interact with sorafenib. Not all possible interactions are listed here. Speak your doctor about all your medications and any you start or stop using during treatment with sorafenib, especially:

· bosentan;

· methadone;

· St. John's wort;

· tacrolimus;

· arsenic trioxide, vandetanib;

· sumatriptan, zolmitriptan;

· an antibiotic--azithromycin, clarithromycin, erythromycin, levofloxacin, moxifloxacin, nafcillin, pentamidine;

· an antidepressant--amitriptyline, citalopram, clomipramine, desipramine;

· heart medication--amiodarone, dofetilide, disopyramide, dronedarone, flecainide, ibutilide, procainamide, propafenone, quinidine, sotalol;

· HIV/AIDS medication--efavirenz, nevirapine, ritonavir;

· malaria medication--chloroquine, halofantrine, mefloquine;

· medication to treat mental illness--chlorpromazine, clozapine, haloperidol, mesoridazine, pimozide, thioridazine, ziprasidone;

· medication to treat or prevent nausea--dolasetron, droperidol, ondansetron;

· seizure medication--carbamazepine, fosphenytoin, oxcarbazepine, phenobarbital, phenytoin, primidone; or

· tuberculosis medicine--rifabutin, rifampin, rifapentine.

• This list is not complete and much another drugs can interact with sorafenib. This includes prescription and over-the-counter medicines, vitamins, and herbal commodity. Give a list of all your medicines to any healthcare provider who treats you.

Where can I get more information?

• Your pharmacist can provide more information about sorafenib.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

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