(EE poe PROST en ol) Brand: Flolan, Veletri
• You must not use this medicine if you are allergic to epoprostenol, if you have breathing problems when you first start using epoprostenol, or if you have congestive heart failure caused by a decrease in your heart's capacity to exhaust blood back into the body.
• Till using epoprostenol, speak your doctor if you have a bleeding or blood clotting mess, heart malady, liver or kidney malady, or tall blood pressure.
• Epoprostenol is injected into a vein using an infusion exhaust, generally through a permanent central intravenous (IV) catheter placed into a big vein (such as in your chest). You may need to use this medicine for much years.
• You may be shown how to use an infusion exhaust at house. Do not self-inject this medication if you do not fully understand how to give the injection and properly dispose of used needles, IV tubing, and another items used to inject the medicine.
• You will receive your first doze of this medication in a hospital or clinic setting to quickly treat any serious side effects that occur. Your blood pressure and heart course may also need to be monitored whenever your doze is changed.
• Speak your doctor about all another drugs you use, especially medicines to prevent blood clots.
• Do not stop using epoprostenol without first talking to your doctor, even if you feel beautiful or have no symptoms. Even short breaks in the flow of your medicine through the IV can reason the treatment to stop working. Missing doses or stopping suddenly may create your condition worse and you may have symptoms such as dizziness, weakness, or trouble breathing.
• Call your doctor if your symptoms do not improve, or if they get worse while using epoprostenol.
• Epoprostenol is a prostaglandin (a hormone-like stuff that occurs naturally in the body). Prostaglandins help to control functions in the body such as blood pressure and muscle contractions.
• Epoprostenol is used to treat pulmonary arterial hypertension (PAH). It improves your capacity to exercise.
• Epoprostenol may also be used for purposes not listed in this medicine guide.
• You must not use this medicine if you are allergic to epoprostenol, if you have breathing problems when you first start using epoprostenol, or if you have congestive heart failure caused by a decrease in your heart's capacity to exhaust blood back into the body.
• To create certain you can safely use epoprostenol, speak your doctor if you have any of these another conditions:
· a bleeding or blood clotting disorder;
· tall blood pressure;
· kidney malady; or
· liver disease.
• FDA pregnancy category B. Epoprostenol is not expected to harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant during treatment.
• It is not known whether epoprostenol passes into breast milk or if it could harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.
• Use exactly as predesigned by your doctor. Do not use in larger or less amounts or for longer than recommended. Follow the directions on your prescription label. You may need to use this medicine for much years.
• Epoprostenol is injected into a vein using a computerized, portable infusion exhaust to control the course of medicine you receive. Because epoprostenol should be used long-term, it is generally given through a permanent central intravenous (IV) catheter placed into a big vein (such as in your chest).
• You may be shown how to use an infusion exhaust at house. Do not self-inject this medication if you do not fully understand how to give the injection and properly dispose of used needles, IV tubing, and another items used to inject the medication.
• You will receive your first doze of this medication in a hospital or clinic setting to quickly treat any serious side effects that occur. Your blood pressure and heart course may also need to be monitored whenever your doze is changed.
• You may be given another medications to prevent blood clots while you are receiving epoprostenol.
• Epoprostenol is a powder medication that should be mixed with a liquid (diluent) till using it. Use only the diluent provided with your medicine and do not mix epoprostenol with any another medications or diluents not authorized by your doctor.
• If you are using the injections at house, be certain you understand how to properly mix and store the medication. These directions are various for the Flolan and Veletri brands of this medicine. Be certain you understand all mixing and storage directions for the specific brand of epoprostenol you are using.
• After mixing Flolan with the diluent, store in the refrigerator and use within 48 hours. After mixing Veletri with the diluent, store in the refrigerator ans use within 5 days.
• The Veletri and diluent mixture may also be stored at room temperature but you should use it within 48 hours after it was mixed.
• Protect the mixed medication from easy and do not freeze. Throw away any epoprostenol and diluent mixture that has become frozen, has changed colors, or has any particles in it. Call your doctor for a new prescription. The epoprostenol and diluent mixture should be protected from easy at all times, whether it is in storage or in use.
• Do not stop using epoprostenol without first talking to your doctor, even if you feel beautiful or have no symptoms. Missing doses or stopping suddenly may create your condition worse and you may have symptoms such as dizziness, weakness, or trouble breathing.
• Even short breaks in the flow of your medicine through the IV can reason the treatment to stop working. To create certain there is no interruption in your treatment, you may need to have a back-up infusion exhaust in case your first exhaust fails to work properly. Also hold replacement batteries and extra IV infusion sets on arm at all times. Get your prescription refilled till you run out of medication completely.
• Call your doctor if your symptoms do not improve, or if they get worse while using epoprostenol.
• Store unopened vials of epoprostenol and its diluent at cold room temperature (below 77 degrees F), away from moisture, heat, and easy. Hold in the original carton.
• Because this medicine is given near the clock, you must not miss a doze if you use the medicine properly. Call your doctor right away if your epoprostenol therapy is interrupted for any reason.
• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.
• Overdose symptoms may include severe forms of some of the side effects listed in this medicine guide.
• Avoid using any infusion exhaust that has not been authorized for use by your doctor.
• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.
• Call your doctor at once if you have a serious side effect such as:
· fever, flu symptoms, mouth and throat ulcers, rapid heart course, rapid and shallow breathing, fainting;
· chest pain, trouble breathing;
· quick, slow, or uneven heart rate;
· pale skin, light bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
· blood in your urine or stools;
· coughing up blood;
· feeling like you might pass out; or
· numbness or heighten sensitivity anywhere in your body.
• Smaller serious side effects may include:
· flushing (warmth, redness, or tingly feeling);
· nausea, vomiting, diarrhea, stomach pain;
· headache or jaw pain;
· joint or muscle pain;
· dizziness, sweating; or
· feeling anxious, nervous, or agitated.
• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.
• Epoprostenol can magnify your risk of bleeding. This effect is heighten when you also use medicines to prevent blood clots, such as:
· heparin or warfarin (Coumadin, Jantoven);
· alteplase (Activase), tenecteplase (TNKase), urokinase (Abbokinase);
· dalteparin (Fragmin), enoxaparin (Lovenox), fondaparinux (Arixtra), tinzaparin (Innohep); or
· abciximab (ReoPro), anagrelide (Agrylin), cilostazol (Pletal), clopidogrel (Plavix), dipyridamole (Persantine, Aggrenox), eptifibatide (Integrelin), prasugrel (Effient), ticlopidine (Ticlid), tirofiban (Aggrastat).
• Speak your doctor about all another medications you use, especially:
· digoxin (digitalis, Lanoxin);
· a diuretic (water pill);
· heart or blood pressure medications;
· aspirin or an NSAID (non-steroidal anti-inflammatory drugs) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others.
• This list is not complete and another drugs may interact with epoprostenol. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.
• Your doctor or pharmacist can provide more information about epoprostenol.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.