ASENAPINE

(a SEN a peen) Brand: Saphris, Saphris Black Cherry

What is the most significant information I must know about asenapine?

• Asenapine is not for use in psychotic conditions related to dementia. Asenapine may reason heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.

• Asenapine can reason serious neurologic problems. Stop taking this medication and call your doctor at once if you have : very stiff (rigid) muscles, tall fever, sweating, confusion, quick or uneven heartbeats, feeling light-headed, tremors, twitching, or uncontrollable movements of your eyes, lips, tongue, person, arms, or legs.

What is asenapine?

• Asenapine is an antipsychotic medicine. It works by changing the actions of chemicals in the brain.

• Asenapine is used to treat the symptoms of psychotic conditions such as schizophrenia and bipolar mess (manic depression) in adults.

• Asenapine may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking asenapine?

• Asenapine is not for use in psychotic conditions related to dementia. Asenapine may reason heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.

• You must not use asenapine if you are allergic to it.

• To create certain asenapine is safety for you, speak your doctor if you have any of these another conditions:

· liver disease;

· heart malady, tall blood pressure, heart rhythm problems;

· a history of heart onslaught or stroke;

· a history of breast cancer;

· seizures or epilepsy;

· diabetes (asenapine may raise your blood sugar);

· trouble swallowing;

· Parkinson's disease;

· a history of low white blood cell (WBC) counts; or

· a private or family history of Long QT syndrome.

• FDA pregnancy category C. Speak your doctor if you are pregnant or plan to become pregnant during treatment.

• Taking antipsychotic medicine during the recent 3 months of pregnancy may reason problems in the newborn such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or another problems if you stop taking your medication during pregnancy. If you become pregnant while taking asenapine, do not stop taking it without your doctor's advice.

• It is not known whether asenapine passes into breast milk or if it could harm a nursing child. You must not breast-feed while using this medicine.

• Do not give this medicine to anyone younger than 18 years old without the advice of a doctor.

How must I take asenapine?

• Asenapine is generally taken 2 times for day. Follow all directions on your prescription label. Do not take this medication in larger or less amounts or for longer than recommended.

• To take asenapine sublingual (under the tongue) tablets:

· Hold the tablet in its blister pack before you are ready to take the medication. Open the package and peel back the colored tab from the tablet blister. Do not push a tablet through the blister or you may hurt the tablet.

· Using dry hands, gently remove the tablet and seat it under your tongue. It will begin to dissolve right away.

· Do not swallow the tablet intact. Let it to dissolve in your mouth without chewing.

· Swallow different times as the tablet dissolves. Do not ate or drink anything for 10 minutes after the tablet has dissolved.

• Asenapine may reason you to have tall blood sugar (hyperglycemia). Symptoms include heighten thirst, heighten urination, famine, dry mouth, fruity breath odor, drowsiness, dry skin, and blurred vision. If you are diabetic, check your blood sugar levels on a regular basis while you are taking asenapine.

• Your doctor will need to check your progress while you are using asenapine.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

What must I avoid while taking asenapine?

• While you are taking asenapine, you may be more sensitive to temperature extremes such as very hot or cool conditions. Avoid getting too cool, or becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercice. It is easier to become dangerously overheated and dehydrated while you are taking asenapine.

• This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

• Avoid getting up too quick from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

• Drinking alcohol can magnify some of the side effects of asenapine.

What are the possible side effects of asenapine?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Stop using asenapine and call your doctor at once if you have:

· very stiff (rigid) muscles, tall fever, sweating, confusion, quick or uneven heartbeats, tremors;

· twitching or uncontrollable movements of your eyes, lips, tongue, person, arms, or legs;

· slow heart course, feeling like you might pass out;

· ulcers, blisters, swelling, or peeling of your gums after using the sublingual tablet;

· sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;

· sudden ill feeling, fever, chills, sore throat, mouth sores, red or swollen gums, trouble swallowing;

· seizure (convulsions); or

· unusual thoughts or behavior, hallucinations, or thoughts about hurting yourself.

• General side effects may include:

· dizziness, drowsiness, restless feeling;

· numbness or tingling internal or near your mouth;

· sleep problems (insomnia); or

· weight gain.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect asenapine?

• Taking asenapine with another drugs that create you sleepy or slow your breathing can worsen these effects. Ask your doctor till taking asenapine with a sleeping pill, narcotic pain medication, muscle relaxer, or medication for anxiety, depression, or seizures.

• Speak your doctor about all medicines you use, and those you start or stop using during your treatment with asenapine, especially:

· methadone;

· tacrolimus;

· arsenic trioxide, vandetanib, vemurafenib;

· an antibiotic--azithromycin, clarithromycin, erythromycin, levofloxacin, moxifloxacin, pentamidine;

· an antidepressant--amitriptyline, bupropion, citalopram, clomipramine, desipramine, fluvoxamine, paroxetine;

· anti-malaria medication--artemether and lumefantrine, chloroquine, halofantrine, mefloquine;

· heart rhythm medicine--amiodarone, dofetilide, disopyramide, dronedarone, flecainide, ibutilide, procainamide, propafenone, quinidine, sotalol;

· medication to prevent or treat nausea and vomiting--dolasetron, droperidol, ondansetron;

· medication to treat a psychiatric disorder--chlorpromazine, clozapine, haloperidol, mesoridazine, pimozide, thioridazine, ziprasidone; or

· migraine headache medicine--sumatriptan, zolmitriptan.

• This list is not complete. Another drugs may interact with asenapine, including prescription and over-the-counter medicines, vitamins, and herbal commodity. Not all possible interactions are listed in this medicine manual.

Where can I get more information?

• Your pharmacist can provide more information about asenapine.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.