SIBUTRAMINE

(si BUE tra meen) Brand: Meridia

What is the most significant information I must know about sibutramine?

• Sibutramine was withdrawn from the U.S. market in October 2010.

• Do not use sibutramine if you have taken an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) in the recent 14 days. Serious, life threatening side effects can occur if you use sibutramine till the MAO inhibitor has cleared from your body.

• You must not take sibutramine if you are allergic to it, or if you have severe or uncontrolled tall blood pressure, an eating mess (anorexia or bulimia), if you are taking stimulant diet pills, or if you have a history of coronary artery malady, stroke, or heart disease.

• Till taking sibutramine, speak your doctor if you have glaucoma, tall blood pressure, liver or kidney malady, depression, underactive thyroid, seizures, a bleeding mess, a history of gallstones, or if you are older than 65 or younger than 16.

• Speak your doctor about all prescription and over-the-counter medications you use, especially antidepressants, cool or allergy medicine, narcotic pain medication, or migraine headache medicines.

• Speak your doctor if you do not lose at least 4 pounds after taking the medicine for 4 weeks along with a low calorie diet.

What is sibutramine?

• Sibutramine was withdrawn from the U.S. market in October 2010.

• Sibutramine affects chemicals in the brain that affect weight maintenance.

• Sibutramine is used together with diet and exercice to treat obesity that may be related to diabetes, tall cholesterol, or tall blood pressure.

• Sibutramine may also be used for another purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking sibutramine?

• You must not take this medicine if you are allergic to sibutramine, or if you have:

· severe or uncontrolled hypertension (high blood pressure);

· an eating mess (anorexia or bulimia);

· a history of coronary artery malady (atherosclerosis);

· a history of heart malady (congestive heart failure, heart rhythm disorder);

· a history of heart onslaught or stroke; or

· if you are taking stimulant diet pills.

• If you have any of these another conditions, you may need a sibutramine doze adjustment or particular tests:

· glaucoma;

· tall blood pressure;

· liver disease;

· kidney disease;

· depression;

· underactive thyroid;

· epilepsy or seizure disorder;

· a bleeding or blood clotting disorder;

· a history of gallstones; or

· if you are older than 65 or younger than 16.

• FDA pregnancy category C. It is not known whether sibutramine will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using sibutramine.

• It is not known whether sibutramine passes into breast milk or if it could harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

• Do not give this medicine to anyone younger than 16 years old.

How must I take sibutramine?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.

• Sibutramine is generally taken once daily. Follow your doctor's instructions.

• Your doctor may occasionally change your doze to create certain you get the excellent results.

• Sibutramine can be taken with or without food.

• You must lose at least 4 pounds during the first 4 weeks of taking sibutramine and eating a low calorie diet. Speak your doctor if you do not lose at least 4 pounds after taking the medicine for 4 weeks.

• Your blood pressure and pulse will need to be checked often. Visit your doctor regularly.

• Sibutramine must not be taken for longer than 2 years.

• Store at room temperature away from moisture, heat, and light.

• Do not share sibutramine with other face. Hold the medicine in a seat where others can't get to it.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose symptoms may include headache, dizziness, and quick heart rate.

What must I avoid while taking sibutramine?

• Sibutramine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

• Do not take any another prescription or over-the-counter weight-loss commodity without your doctor's advice.

• Avoid taking cough and cool or allergy medications while taking sibutramine.

• Avoid drinking alcohol while taking sibutramine.

What are the possible side effects of sibutramine?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• Stop using sibutramine and call your doctor at once if you have a serious side effect such as:

· quick, pounding, or uneven heartbeats;

· new or worsening shortness of breath;

· agitation, hallucinations, fever, tremor, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, dilated pupils;

· very stiff (rigid) muscles, tall fever, sweating, confusion, feeling like you might pass out;

· light bruising or bleeding (nosebleeds, bleeding gums, or any bleeding that will not stop);

· dangerously tall blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, seizure);

· chest pain or hard feeling, pain spreading to the hand or shoulder, common ill feeling; or

· sudden numbness or weakness (especially on one side of the body), problems with vision, speech, or balance.

• Smaller serious side effects may include:

· dry mouth, upset stomach;

· changes in appetite;

· constipation, stomach pain;

· headache, back pain, joint pain;

· feeling nervous, dizzy, or depressed;

· flu symptoms, runny or stuffy nose, sore throat, cough;

· warmth, redness, or tingly feeling under your skin;

· trouble sleeping (insomnia); or

· mild skin rash.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect sibutramine?

• Till using sibutramine, speak your doctor if you regularly use another medicines that create you sleepy (such as cool or allergy medication, sedatives, narcotic pain medication, sleeping pills, muscle relaxers, and medication for seizures, depression, or anxiety). They can add to sleepiness caused by sibutramine.

• Ask your doctor till taking any decongestants, cough medication, or another diet pills.

• The next drugs can interact with sibutramine. Speak your doctor if you are using any of these:

· lithium (Lithobid, Eskalith, and others);

· tryptophan or L-tryptophan;

· ketoconazole (Nizoral);

· an antibiotic such as erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin);

· an antidepressant such as citalopram (Celexa), desvenlafaxine (Pristiq), duloxetine (Cymbalta), fluoxetine (Prozac, Sarafem, Symbyax), paroxetine (Paxil), sertraline (Zoloft), venlafaxine (Effexor), and others;

· ergot medication such as dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), ergotamine (Ergomar), or methylergonovine (Methergine).

· migraine headache medication such as sumatriptan (Imitrex) or zolmitriptan (Zomig); or

· narcotic pain medicine such as fentanyl (Actiq, Duragesic, Fentora, Onsolis), meperidine (Demerol), pentazocine (Talwin).

• This list is not complete and another drugs may interact with sibutramine. Speak your doctor about all medications you use. This includes prescription, over the counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about sibutramine.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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