ROFLUMILAST

(roe FLOO mi last) Brand: Daliresp

What is the most significant information I must know about roflumilast?

• You must not use roflumilast if you are allergic to it, or if you have temperate or severe liver disease.

• There are much another drugs that can create roflumilast smaller effective and must not be used at the same time. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

• Till you take roflumilast, speak your doctor if you have liver malady or a history of depression, mental diseases, or suicidal thoughts or actions.

• You may have unusual thoughts or behavior, or thoughts about suicide, while taking this medication. Speak your doctor if you have new or worsening depression, or suicidal thoughts. Your family or another caregivers must also be alert to changes in your mood or symptoms.

• Message any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, depression, trouble sleeping, or if you feel impulsive, or you have thoughts about suicide or hurting yourself.

• Call your doctor at once if you have rapid and unintended weight loss.

What is roflumilast?

• Roflumilast reduces inflammation in the lungs that leads to COPD (chronic obstructive pulmonary disease).

• Roflumilast is used to prevent worsening of chronic obstructive pulmonary malady (COPD) in people with severe COPD and chronic bronchitis.

• Roflumilast is not a bronchodilator. It will not treat a bronchospasm onslaught that has already begun.

• Roflumilast may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking roflumilast?

• You must not use roflumilast if you are allergic to it, or if you have temperate or severe liver disease.

• There are much another drugs that can create roflumilast smaller effective and must not be used at the same time. This includes:

· bosentan (Tracleer);

· dexamethasone (Cortastat, Dexasone, Solurex, DexPak);

· St. John's wort;

· rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate), or rifapentine (Priftin);

· a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton);

· HIV medicine such as efavirenz (Sustiva, Atripla), etravirine (Intelence), nevirapine (Viramune), or ritonavir (Norvir, Kaletra);

· medicines to treat narcolepsy, such as armodafinil (Nuvigil) or modafinil (Progivil); or

· seizure medicine such as carbamazepine (Carbatrol, Equetro, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), phenytoin (Dilantin), or primidone (Mysoline).

• To create certain you can safely take roflumilast, speak your doctor if you have any of these another conditions:

· liver disease;

· a history of depression, mental diseases, or suicidal thoughts or actions.

• FDA pregnancy category C. It is not known whether roflumilast will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.

• Roflumilast can pass into breast milk and may harm a nursing child. You must not breast-feed while you are using roflumilast.

• Do not give this medicine to anyone under 18 years old without medical advice. Do not share this medicine with another people, even if they have the same symptoms you have.

How must I take roflumilast?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.

• Roflumilast is generally taken once for day, with or without food. Follow your doctor's instructions.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose symptoms may include quick or pounding heartbeats, cool or clammy skin, or feeling like you might pass out.

What must I avoid while taking roflumilast?

• Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of roflumilast?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• You may have unusual thoughts or behavior, or thoughts about suicide, while taking this medication. Message any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, depression, trouble sleeping, or if you feel impulsive, or you have thoughts about suicide or hurting yourself.

• Call your doctor at once if you have a serious side effect such as:

· rapid and unintended weight loss;

· tremors;

· pain or burning when you urinate;

• Smaller serious side effects may include:

· nausea, diarrhea, stomach pain;

· loss of appetite, minor weight loss;

· dizziness;

· runny or stuffy nose;

· back pain; or

· flu symptoms.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect roflumilast?

• Speak your doctor about all another medicines you use, especially:

· birth control pills;

· cimetidine (Tagamet);

· conivaptan (Vaprisol);

· imatinib (Gleevec);

· isoniazid (for treating tuberculosis);

· lidocaine (Xylocaine);

· methoxsalen (Oxsoralen, Uvadex, 8-Mop);

· primaquine (anti-malaria medication);

· an antidepressant such as fluvoxamine (Luvox) or nefazodone;

· an antibiotic such as ciprofloxacin (Cipro), clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), norfloxacin (Noroxin), ofloxacin (Floxin), or telithromycin (Ketex);

· antifungal medicine such as itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig), or thiabendazole (Mintezol);

· heart or blood pressure medicine such as amiodarone (Cordarone, Pacerone), mexiletine (Mexitil), nicardipine (Cardene) or quinidine (Quin-G);

· HIV/AIDS medication such as atazanavir (Reyataz), delavirdine (Rescriptor), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase), or ritonavir (Norvir, Kaletra);

• This list is not complete and another drugs may interact with roflumilast. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about roflumilast.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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