(ez ET i mibe and SIM va stat in) Brand: Vytorin
What is the most significant information I must know about ezetimibe and simvastatin?
You must not use this medication if you have active liver malady or emergency liver function tests.
The next drugs must not be used while you are taking ezetimibe and simvastatin: boceprevir, cyclosporine, danazol, gemfibrozil, imatinib, isoniazid, nefazodone, nicardipine, quinidine, telaprevir, determined antibiotics (clarithromycin, erythromycin, telithromycin), antifungal medicine (itraconazole, ketoconazole, posaconazole, voriconazole), or determined HIV/AIDS medicine (atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir).
Do not use ezetimibe and simvastatin if you are pregnant or if you could become pregnant. Use effective birth control.
Do not breast-feed while using this medicine.
What is ezetimibe and simvastatin?
Ezetimibe reduces the amount of cholesterol absorbed by the body.
Simvastatin is in a group of drugs called HMG CoA reductase inhibitors, or "statins."
Ezetimibe and simvastatin is a combination medication that reduces blood levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL).
Ezetimibe and simvastatin is used together with a low-fat diet and another treatments to lower total cholesterol in adults and children who are at least 10 years old. It is not known whether this medication reduces your risk of heart disease.
Ezetimibe and simvastatin may also be used for purposes not listed in this medicine guide.
What must I discuss with my healthcare provider till taking ezetimibe and simvastatin?
You must not use this medication if you are allergic to simvastatin (Zocor) or ezetimibe (Vytorin, Zetia), or if you have:
· active liver malady;
· emergency liver function trials; or
· if you are pregnant or breast-feeding.
The next drugs can magnify your risk of serious muscle problems if you take them together with ezetimibe and simvastatin. These drugs must not be used while you are taking simvastatin:
· an antibiotic--clarithromycin, erythromycin, telithromycin;
· antifungal medication--itraconazole, ketoconazole, posaconazole, voriconazole;
· heart medication--nicardipine, quinidine;
· hepatitis C medications--boceprevir, telaprevir; or
· HIV/AIDS medication--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir.
Before you start taking ezetimibe and simvastatin, speak your doctor if you are already using any of these another medicines:
· amlodipine (sometimes in combination medicines--Caduet, Exforge, Lotrel, Tekamlo, Tribenzor, Twynsta, Amturnide);
· ranolazine; or
To create certain ezetimibe and simvastatin is safety for you, speak your doctor if you have:
· a thyroid disorder;
· a history of liver or kidney disease;
· a history of liver problems caused by alcohol;
· low blood pressure;
· an electrolyte imbalance (such as low levels of potassium or magnesium in your blood);
· untreated or uncontrolled seizures;
· if you drink big amounts of alcohol;
· if you are older than 65; or
· if you are of Chinese descent.
FDA pregnancy category X. This medicine can harm an unborn child or reason birth defects. Do not take ezetimibe and simvastatin if you are pregnant. Use effective birth control. Stop using the medication and speak your doctor right away if you become pregnant.
It is not known whether ezetimibe and simvastatin passes into breast milk or if it could harm a nursing child. Do not breast-feed while using this medicine.
How must I take ezetimibe and simvastatin?
Follow all directions on your prescription label. Your doctor may occasionally change your doze to create certain you get the excellent results. Do not take this medication in larger or less amounts or for longer than recommended.
While using this medication, you may need frequent blood tests.
If you have major surgery or a severe injury or infection, create certain any doctor caring for you knows you are taking ezetimibe and simvastatin.
Ezetimibe and simvastatin is only part of a complete program of treatment that also includes diet, exercice, and weight control. Follow your diet, medicine, and exercice routines very closely.
Store at room temperature away from moisture and heat. Hold the bottle tightly closed when not in use.
What happens if I miss a dose?
Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.
What happens if I overdose?
Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.
What must I avoid while taking ezetimibe and simvastatin?
Grapefruit and grapefruit juice may interact with this medication and lead to unwanted side effects. Avoid the use of grapefruit commodity while taking ezetimibe and simvastatin.
If you also take cholestyramine, colesevelam, or colestipol: Space your doses separately in order to take ezetimibe and simvastatin either 2 hours till or 4 hours after you take any of these another medications.
Avoid drinking alcohol. It can raise triglyceride levels and may magnify your risk of liver damage.
Avoid eating foods that are tall in thick or cholesterol. Ezetimibe and simvastatin will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.
What are the possible side effects of ezetimibe and simvastatin?
Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.
In rare cases, simvastatin can reason a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.
Stop using this medication and call your doctor at once if you have:
· few or no urinating, pain in your side or lower back;
· swelling, rapid weight gain;
· nausea, upper stomach pain, loss of appetite, unusual tiredness; or
· dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
General side effects may include:
· diarrhea; or
· cool symptoms such as stuffy nose, sneezing, sore throat;
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.
What another drugs will affect ezetimibe and simvastatin?
Much drugs can interact with ezetimibe and simvastatin. Not all possible interactions are listed here. Speak your doctor about all your medications and any you start or stop using during treatment with ezetimibe and simvastatin, especially:
· digoxin, digitalis;
· fenofibrate, fenofibric acid;
· a blood thinner (warfarin, Coumadin); or
· medicines that contain niacin, or vitamin B3, such as Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others;.
This list is not complete and much another drugs can reason serious or life-threatening medical problems if used together with ezetimibe and simvastatin. This includes prescription and over-the-counter medicines, vitamins, and herbal commodity. Give a list of all your medicines to any healthcare provider who treats you.
Where can I get more information?
Your pharmacist can provide more information about ezetimibe and simvastatin.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
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