DEXTROMETHORPHAN, PHENYLEPHRINE, AND PYRILAMINE

(dex troe meh THOR fan, feh nill EH frin, pie RIH la meen) Brand: Codal-DM Syrup, Codimal DM, Codituss DM, Poly Hist DM

What is the most significant information I must know about dextromethorphan, phenylephrine, and pyrilamine?

• Always ask a doctor till giving a cough or cool medication to a child. Death can occur from the misuse of cough and cool medicines in very young children.

• Do not use a cough or cool medication if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take cough or cool medication till the MAO inhibitor has cleared from your body.

• Do not use any another over-the-counter cough, cool, allergy, or sleep medicine without first asking your doctor or pharmacist. If you take determined commodity together you may accidentally take too many of one or more types of medication. Read the label of any another medication you are using to see if it contains an antihistamine, decongestant, or cough suppressant.

• Dextromethorphan, phenylephrine, and pyrilamine can reason side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

• Avoid drinking alcohol. It can magnify some of the side effects of this medication.

What is dextromethorphan, phenylephrine, and pyrilamine?

• Dextromethorphan is a cough suppressant. It affects the signals in the brain that trigger cough reflex.

• Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can reason nasal congestion (stuffy nose).

• Pyrilamine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can manufacture symptoms of sneezing, itching, watery eyes, and runny nose.

• The combination of dextromethorphan, phenylephrine, and pyrilamine is used to treat sneezing, cough, runny or stuffy nose, itchy or watery eyes, hives, skin rash, itching, and another symptoms of allergies and the general cold.

• Dextromethorphan will not treat a cough that is caused by smoking, asthma, or emphysema.

• Dextromethorphan, phenylephrine, and pyrilamine may also be used for purposes another than those listed in this medicine guide.

What must I discuss with my healthcare provider till taking dextromethorphan, phenylephrine, and pyrilamine?

• Till taking this medicine, speak your doctor if you are allergic to dextromethorphan, phenylephrine, or pyrilamine, or if you have:

· kidney disease;

· liver disease;

· diabetes;

· glaucoma;

· heart malady or tall blood pressure;

· a thyroid disorder;

· a stomach ulcer or a stomach obstruction;

· emphysema or chronic bronchitis; or

· an enlarged prostate or urination problems.

• If you have any of these conditions, you may not be able to use dextromethorphan, phenylephrine, and pyrilamine, or you may need a dosage adjustment or particular trials during treatment.

• FDA pregnancy category C. This medicine may be deleterious to an unborn child. Speak your doctor if you are pregnant or plan to become pregnant during treatment.

• Dextromethorphan, phenylephrine, and pyrilamine can pass into breast milk and may harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

• Artificially-sweetened liquid forms of cough-and-cold medications may contain phenylalanine. This would be significant to know if you have phenylketonuria (PKU). Check the ingredients and warnings on the medicine label if you are concerned about phenylalanine.

How must I take dextromethorphan, phenylephrine, and pyrilamine?

• Use this medicine exactly as directed on the label or as it was predesigned for you. Do not take the medicine in larger amounts, or take it for longer than recommended by your doctor.

• Always ask a doctor till giving a cough or cool medication to a child. Death can occur from the misuse of cough and cool medicines in very young children.

• Take this medication with a full glass of water.

• Measure the liquid form of this medication with a particular dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

• Take this medication with food or milk if it upsets your stomach.

• This medicine can reason you to have unusual results with allergy skin trials. Speak any doctor who treats you that you are taking an antihistamine.

• Conversation with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

• If you need to have any type of surgery, speak the surgeon onward of time if you have taken a cool medication within the past little days.

• Store the medicine at room temperature away from moisture and heat.

What happens if I miss a dose?

• Since cough or cool medication is generally taken only as needed, you may not be on a dosing schedule. If you are taking the medicine regularly, take the missed doze as soon as you remember. If it is nearly time for your following doze, skip the missed doze and take the medication at your following regularly scheduled time. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention if you think you have used too many of this medicine.

• Symptoms of an overdose may include feeling restless or nervous, nausea, vomiting, stomach pain, dizziness, drowsiness, dry mouth, warmth or tingly feeling, or seizure (convulsions). confusion, blurred vision, dry mouth, nausea, vomiting, and seizure (convulsions).

What must I avoid while taking dextromethorphan, phenylephrine, and pyrilamine?

• This medicine can reason side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

• Avoid drinking alcohol. It can magnify some of the side effects of this medication.

• Avoid using another medicines that create you sleepy (such as cool medication, pain medicine, muscle relaxers, and medication for seizures, depression or anxiety). They can add to sleepiness caused by dextromethorphan, phenylephrine, and pyrilamine.

• Avoid taking diet pills, caffeine pills, or another stimulants (such as ADHD medications) without your doctor's advice. Taking a stimulant together with a decongestant can magnify your risk of unpleasant side effects.

• Do not use any another over-the-counter cough, cool, allergy, or sleep medicine without first asking your doctor or pharmacist. Antihistamines, decongestants, and cough suppressants are contained in much medicines accessible over the counter. If you take determined commodity together you may accidentally take too many of one or more types of medication. Read the label of any another medication you are using to see if it contains an antihistamine, decongestant, or cough suppressant.

What are the possible side effects of dextromethorphan, phenylephrine, and pyrilamine?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Stop using this medicine and call your doctor at once if you have any of these serious side effects:

· quick, pounding, or uneven heartbeat;

· confusion, hallucinations, unusual thoughts or behavior;

· severe dizziness, anxiety, restless feeling, or nervousness;

· heighten blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure);

· confusion, hallucinations;

· slow, shallow breathing;

· urinating smaller than normal or not at all;

· light bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms; or

· nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

• Hold taking the medicine and conversation to your doctor if you have any of these smaller serious side effects:

· blurred vision;

· dry mouth;

· nausea, stomach pain, constipation;

· mild loss of appetite, stomach upset;

· warmth, tingling, or redness under your skin;

· feeling excited or restless;

· sleep problems (insomnia);

· restless or excitability (especially in children);

· skin rash or itching;

· dizziness, drowsiness;

· problems with memory or concentration; or

· ringing in your ears.

• Side effects another than those listed here may also occur. Conversation to your doctor about any side effect that seems unusual or that is especially bothersome. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect dextromethorphan, phenylephrine, and pyrilamine?

• Till taking this medicine, speak your doctor if you are using any of the next drugs:

· an antidepressant;

· a diuretic (water pill);

· medicine to treat irritable bowel syndrome;

· celecoxib (Celebrex);

· cinacalcet (Sensipar);

· darifenacin (Enablex);

· imatinib (Gleevec);

· quinidine (Quinaglute, Quinidex);

· ranolazine (Ranexa)

· ritonavir (Norvir);

· sibutramine (Meridia);

· terbinafine (Lamisil);

· medicines to treat tall blood pressure;

· aspirin or salicylates (such as Disalcid, Doan's Pills, Dolobid, Salflex, Tricosal, and others);

· bladder or urinary medications such as oxybutynin (Ditropan, Oxytrol) or tolterodine (Detrol); or

· a beta-blocker such as atenolol (Tenormin), carteolol (Cartrol), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal), sotalol (Betapace), timolol (Blocadren), and others.

• There may be another drugs that can affect dextromethorphan, phenylephrine, and pyrilamine. Speak your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal commodity, and drugs predesigned by another doctors. Do not start using a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist has information about dextromethorphan, phenylephrine, and pyrilamine written for health professionals that you may read.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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