ATORVASTATIN AND EZETIMIBE

(a TOR va STAT in and e ZET i mibe) Brand: Liptruzet

What is the most significant information I must know about atorvastatin and ezetimibe?

• You must not use this medication if you have active liver malady or emergency liver function tests.

• Do not use atorvastatin and ezetimibe if you are pregnant or if you could become pregnant. Use effective birth control.

• Do not breast-feed while using this medicine.

What is atorvastatin and ezetimibe?

• Ezetimibe reduces the amount of cholesterol absorbed by the body.

• Atorvastatin is in a group of drugs called HMG CoA reductase inhibitors, or "statins."

• Atorvastatin and ezetimibe is a combination medication that reduces blood levels of "bad" cholesterol, such as low-density lipoprotein (LDL), apolipoprotein-B (apo-B), triglycerides, or non-high-density lipoprotein (non-HDL).

• Atorvastatin and ezetimibe is used together with a low-fat diet and another treatments to lower total cholesterol in adults with familial hypercholesterolemia (an inherited type of tall cholesterol).

• It is not known whether atorvastatin and ezetimibe reduces your risk of heart disease.

• Atorvastatin and ezetimibe may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking atorvastatin and ezetimibe?

• You must not use this medication if you are allergic to atorvastatin (Lipitor) or ezetimibe (Vytorin, Zetia), or if you have:

· active liver malady;

· emergency liver function trials; or

· if you are pregnant or breast-feeding.

• To create certain this medication is safety for you, speak your doctor if you have:

· a thyroid disorder;

· a history of liver or kidney disease;

· a history of liver problems caused by alcohol;

· gallbladder malady or a history of gallstones;

· low blood pressure;

· a history of blood clot or stroke, including "mini-stroke" (TIA);

· diabetes;

· an electrolyte imbalance (such as low levels of potassium or magnesium in your blood);

· untreated or uncontrolled seizures;

· if you drink big amounts of alcohol; or

· if you are older than 65.

• FDA pregnancy category X. This medicine can harm an unborn child or reason birth defects. Do not use atorvastatin and ezetimibe if you are pregnant. Use effective birth control. Stop using the medication and speak your doctor right away if you become pregnant.

• It is not known whether atorvastatin and ezetimibe passes into breast milk or if it could harm a nursing child. You must not breast-feed while using this medicine.

How must I take atorvastatin and ezetimibe?

• Follow all directions on your prescription label. Your doctor may occasionally change your doze to create certain you get the excellent results. Do not take this medication in larger or less amounts or for longer than recommended.

• Do not crush, chew, or dissolve an atorvastatin and ezetimibe tablet. Swallow it intact.

• While using this medication, you may need frequent blood trials.

• If you have major surgery or a severe injury or infection, create certain any doctor caring for you knows you are taking atorvastatin and ezetimibe.

• Store at room temperature away from moisture and heat. Hold the medication in the foil pouch or plastic case when not in use.

• After opening a foil pouch, store it in a dry seat protected from easy. Discard any tablets not used within 30 days after opening the pouch.

• Every time you take a tablet out of a blister card, seat the card back into the plastic case.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

What must I avoid while taking atorvastatin and ezetimibe?

• Grapefruit and grapefruit juice may interact with this medication and lead to unwanted side effects. Avoid the use of grapefruit commodity while taking atorvastatin and ezetimibe.

• Avoid eating foods that are tall in thick or cholesterol. Atorvastatin and ezetimibe will not be as effective in lowering your cholesterol if you do not follow a cholesterol lowering diet plan.

• If you also take cholestyramine, colesevelam, or colestipol: Space your doses separately in order to take atorvastatin and ezetimibe either 2 hours till or 4 hours after you take any of these another medications.

What are the possible side effects of atorvastatin and ezetimibe?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• In rare cases, atorvastatin can reason a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

• Stop using this medication and call your doctor at once if you have:

· nausea, upper stomach pain, loss of appetite;

· itching, unusual tiredness; or

· dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

• General side effects may include:

· mild muscle pain;

· stomach pain, diarrhea; or

· joint pain.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect atorvastatin and ezetimibe?

• Much drugs can interact with this medication. Not all possible interactions are listed here. Speak your doctor about all your medications and any you start or stop using during treatment with atorvastatin and ezetimibe, especially:

· colchicine;

· cyclosporine;

· digoxin, digitalis;

· imatinib;

· isoniazid;

· nefazodone;

· niacin, vitamin B3;

· St. John's wort;

· an antibiotic--clarithromycin, erythromycin, rifampin, telithromycin;

· antifungal medication--itraconazole, ketoconazole, posaconazole, voriconazole;

· birth control pills;

· a blood thinner (warfarin, Coumadin);

· heart medication--nicardipine, quinidine;

· hepatitis C medications--boceprevir, telaprevir;

· HIV/AIDS medication--atazanavir, darunavir, delavirdine, efavirenz, fosamprenavir, indinavir, lopinavir, nelfinavir, nevirapine, ritonavir, saquinavir, tipranavir;

· another cholesterol medications, especially fenofibrate, fenofibric acid, gemfibrozil, or any another "statin" medicine.

· seizure medication--carbamazepine, fosphenytoin, oxcarbazepine, phenobarbital, phenytoin, primidone; or

· tuberculosis medication--rifabutin, rifampin, rifapentine.

• This list is not complete and much another drugs can interact with atorvastatin and ezetimibe. This includes prescription and over-the-counter medicines, vitamins, and herbal commodity. Give a list of all your medicines to any healthcare provider who treats you.

Where can I get more information?

• Your pharmacist can provide more information about atorvastatin and ezetimibe.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.