(TEM sir OH li mus) Brand: Torisel
• You must not use this medicine if you are allergic to temsirolimus or if you have severe liver disease.
• Do not use temsirolimus if you are pregnant. It could harm the unborn child. Use an effective form of birth control while you are using this medicine and for at least 3 months after your treatment ends.
• If a man fathers a baby while using this medicine, the child may have birth defects. Use a condom to prevent pregnancy during your treatment. Continue using condoms for at least 3 months after you stop using temsirolimus.
• Till you receive temsirolimus, speak your doctor if you have liver malady, tall cholesterol, diabetes, an allergy to sirolimus (Rapamune), or a history of head injury, stroke, or brain tumor.
• Temsirolimus can lower blood cells that help your body fight infections. Your blood may need to be tested often. Avoid being around people who are sick or have infections. Do not receive a live vaccine. Speak your doctor at once if you develop signs of infection.
• There are much another drugs that can interact with temsirolimus. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor. Hold a list of all your medicines and show it to any healthcare provider who treats you.
• Temsirolimus is a cancer medicine that interferes with the growth and spread of cancer cells in the body.
• Temsirolimus is used to treat cancer of the kidneys, also called renal cell carcinoma.
• Temsirolimus may also be used for purposes not listed in this medicine guide.
• You must not use this medicine if you are allergic to temsirolimus or if you have severe liver disease.
• To create certain you can safely receive temsirolimus, speak your doctor if you have any of these another conditions:
· liver disease;
· tall cholesterol or triglycerides (a type of thick in the blood);
· diabetes;
· a history of head injury, stroke, or brain tumor; or
· if you are allergic to sirolimus (Rapamune).
• FDA pregnancy category D. Do not use temsirolimus if you are pregnant. It could harm the unborn child. Use effective birth control while you are using this medicine and for at least 3 months after your treatment ends.
• If a man fathers a baby while using this medicine, the child may have birth defects. Use a condom to prevent pregnancy during your treatment. Continue using condoms for at least 3 months after you stop using temsirolimus.
• It is not known whether temsirolimus passes into breast milk or if it could harm a nursing child. You must not breast-feed while you are using temsirolimus.
• Temsirolimus is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting. Temsirolimus should be given slowly, and the IV infusion can take up to 60 minutes to complete.
• Temsirolimus is generally given once every week unless your cancer progresses or you have serious side effects from the medication.
• You may receive another medications till your temsirolimus infusion. These medications will help prevent determined side effects.
• Temsirolimus can lower blood cells that help your body fight infections. This can create it easier for you to bleed from an injury or get sick from being near others who are ill. Your blood may need to be tested often. Your kidney function may also need to be tested. Visit your doctor regularly.
• If you need surgery, speak the surgeon onward of time that you are using temsirolimus. You may need to stop using the medication for a short time.
• Call your doctor if you miss an appointment for your temsirolimus injection.
• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.
• Overdose symptoms may include severe forms of some of the side effects listed in this medicine guide.
• Avoid being around people who are sick or have infections. Speak your doctor at once if you develop signs of infection.
• This medication can pass into body fluids (including urine, feces, vomit, semen, vaginal fluid). For at least 48 hours after you receive a doze, avoid allowing your body fluids to come into contact with your hands or another surfaces. Patients and caregivers must wear rubber gloves while cleaning up body fluids, handling contaminated trash or laundry or changing diapers. Wash hands till and after removing gloves. Wash soiled clothing and linens apart from another laundry.
• Body fluids must not be handled by a woman who is pregnant or who may become pregnant. Use condoms during sexual activity to avoid exposure to body fluids.
• Do not receive a "live" vaccine while using temsirolimus, and avoid coming into contact with anyone who has recently received a live vaccine. There is a chance that the virus could be passed on to you. Live vaccines include measles, mumps, rubella (MMR), Bacillus Calmette-Guérin (BCG), oral polio, rotavirus, smallpox, typhoid, yellow fever, varicella (chickenpox), H1N1 influenza, and nasal flu vaccine.
• Grapefruit and grapefruit juice may interact with temsirolimus and lead to potentially dangerous effects. Discuss the use of grapefruit commodity with your doctor.
• Some people receiving a temsirolimus injection have had a reaction to the infusion (when the medication is injected into the vein). Speak your caregiver right away if you feel dizzy, warm, tingly, light-headed, short of breath, or have chest pain or trouble breathing during the injection.
• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.
• Call your doctor at once if you have a serious side effect such as:
· fever, chills, body aches, flu symptoms, sores in your mouth and throat;
· chest pain, dry cough, wheezing, feeling short of breath;
· severe stomach pain, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
· drowsiness, confusion, mood changes, swelling, rapid weight gain;
· loss of movement on one side of your body;
· urinating smaller than normal or not at all;
· pain or burning when you urinate;
· pale skin, feeling light-headed or short of breath, rapid heart course, trouble concentrating;
· light bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
· any wound that will not heal; or
· tall blood sugar (increased thirst, heighten urination, famine, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss).
• Smaller serious side effects include mild skin rash
· acne, dry skin, mild itching or rash;
· nausea, vomiting, loss of appetite;
· diarrhea, constipation;
· hair loss;
· muscle or joint pain, back pain;
· headache, dizziness, problems with coordination;
· pain, warmth, swelling, redness, itching, or irritation near the IV needle.
· runny or stuffy nose, sinus pain;
· depression, memory problems, sleep problems (insomnia), feeling weak or weary;
· decreased sense of taste; or
• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.
• Speak your doctor about all another medicines you use, especially:
· conivaptan;
· imatinib;
· isoniazid (for treating tuberculosis);
· St. John's wort;
· sunitinib;
· a blood thinner such as warfarin;
· insulin or oral diabetes medications;
· an antibiotic such as clarithromycin, erythromycin, rifabutin, rifampin, or telithromycin;
· an antidepressant such as citalopram, escitalopram, fluoxetine, fluvoxamine, nefazodone, paroxetine, or sertraline;
· antifungal medicine such as itraconazole, ketoconazole, miconazole, or voriconazole;
· heart or blood pressure medicine such as nicardipine or quinidine;
· HIV/AIDS medication such as atazanavir, delavirdine, indinavir, nelfinavir, saquinavir or ritonavir; or
· seizure medicine such as carbamazepine, phenytoin, or phenobarbital.
• This list is not complete and there are much another drugs that can interact with temsirolimus. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor. Hold a list of all your medicines and show it to any healthcare provider who treats you.
• Your doctor or pharmacist can provide more information about temsirolimus.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
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