PENTOSAN POLYSULFATE SODIUM

(PEN toe san POL ee SUL fate SOE dee um) Brand: Elmiron

What is the most significant information I must know about pentosan polysulfate sodium?

• Till taking pentosan polysulfate sodium, speak your doctor if you have a bleeding or blood clotting mess, a history of aneurysm or stroke, a stomach ulcer, intestinal polyps, diverticulitis, or liver disease.

• Take the medication on an empty stomach, at least 1 hour till or 2 hours after a meal.

• Call your doctor at once if you have any light bruising or unusual bleeding such as nosebleed, blood in your urine or stools, rectal bleeding, coughing up blood, bleeding gums, or feeling like you might pass out.

• To be certain this medicine is helping your condition, your doctor will need to check your progress each 3 months. This will help your doctor determine how long to treat you with pentosan polysulfate sodium. You may also need blood trials to check for determined side effects. Visit your doctor regularly.

• Speak your doctor if you use any another medications that can magnify your risk of bleeding, including blood thinners, medications to treat or prevent blood clots, or an NSAID (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), indomethacin (Indocin), and others.

What is pentosan polysulfate sodium?

• Pentosan polysulfate sodium works like an anticoagulant (blood thinner) that prevents the formation of blood clots. However, it is used to treat bladder pain and discomfort caused by cystitis (bladder inflammation or irritation).

• Pentosan polysulfate sodium may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking pentosan polysulfate sodium?

• You must not use this medicine if you are allergic to pentosan polysulfate sodium.

• To create certain you can safely take pentosan polysulfate sodium, speak your doctor if you have any of these another conditions:

· a bleeding or blood clotting disorder;

· a history of aneurysm or stroke;

· a stomach ulcer, intestinal polyps or diverticulitis; or

· liver disease.

• FDA pregnancy category B. Pentosan polysulfate sodium is not expected to harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant during treatment.

• It is not known whether pentosan polysulfate sodium passes into breast milk or if it could harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

How must I take pentosan polysulfate sodium?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.

• Take the medication on an empty stomach, at least 1 hour till or 2 hours after a meal.

• If you need surgery, speak the surgeon onward of time that you are using pentosan polysulfate sodium. You may need to stop using the medication for a short time.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose symptoms may include light bruising or unusual bleeding.

What must I avoid while taking pentosan polysulfate sodium?

• Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of pentosan polysulfate sodium?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Call your doctor at once if you have a serious side effect such as:

· nosebleed;

· blood in your urine or stools;

· rectal bleeding;

· coughing up blood;

· bleeding gums; or

· feeling like you might pass out.

• Smaller serious side effects may include:

· hair loss;

· nausea, diarrhea, stomach pain;

· headache;

· mild dizziness;

· depressed mood; or

· mild itching or skin rash.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect pentosan polysulfate sodium?

• Speak your doctor if you use any another medications that can magnify your risk of bleeding, such as:

· abciximab (ReoPro);

· alteplase (Activase);

· anagrelide (Agrylin);

· argatroban (Acova);

· aspirin;

· bivalirudin (Angiomax);

· cilostazol (Pletal);

· clopidogrel (Plavix);

· dalteparin (Fragmin);

· dipyridamole (Persantine, Aggrenox);

· enoxaparin (Lovenox);

· eptifibatide (Integrelin);

· fondaparinux (Arixtra);

· heparin or warfarin (Coumadin);

· lepirudin (Refludan);

· prasugrel (Effient);

· ticlopidine (Ticlid);

· tirofiban (Aggrastat);

· tenecteplase (TNKase);

· urokinase (Abbokinase); or

· an NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen (Motrin, Advil), diclofenac (Cataflam, Voltaren), etodolac (Lodine), indomethacin (Indocin), meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Naprosyn), piroxicam (Feldene), and others.

• This list is not complete and another drugs may interact with pentosan polysulfate sodium. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about pentosan polysulfate sodium.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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