PALIPERIDONE

(pal ee For i done) Brand: Invega

What is the most significant information I must know about paliperidone?

• Paliperidone is not for use in psychotic conditions related to dementia. Paliperidone may reason heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.

• While you are taking paliperidone, you may be more sensitive to temperature extremes such as very hot or cool conditions. Avoid getting too cool, or becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercice. It is easier to become dangerously overheated and dehydrated while you are taking paliperidone.

• Paliperidone may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

• Till using paliperidone, speak your doctor if you regularly use another medicines that create you sleepy (such as cool or allergy medication, sedatives, narcotic pain medication, sleeping pills, muscle relaxers, and medication for seizures, depression, or anxiety). They can add to sleepiness caused by paliperidone.

• Drinking alcohol can magnify determined side effects of paliperidone.

• Stop taking paliperidone and call your doctor at once if you have very stiff (rigid) muscles, tall fever, sweating, confusion, quick or uneven heartbeats, tremors, restless muscle movements in your person or neck, tremor (uncontrolled shaking), trouble swallowing, or feeling like you might pass out.

What is paliperidone?

• Paliperidone is an antipsychotic medicine. It works by changing the effects of chemicals in the brain.

• Paliperidone is used to treat schizophrenia.

• Paliperidone may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking paliperidone?

• You must not use this medicine if you are allergic to paliperidone or a similar drug called risperidone (Risperdal).

• To create certain you can safely take paliperidone, speak your doctor if you have any of these another conditions:

· a history of low white blood cell (WBC) counts;

· a private or family history of Long QT syndrome;

· heart malady, heart rhythm problems, or a history of heart onslaught or stroke;

· tall or low blood pressure;

· an electrolyte imbalance, such as low potassium or magnesium levels in your blood;

· a history of breast cancer;

· seizures or epilepsy;

· kidney or liver disease;

· diabetes (paliperidone may raise your blood sugar);

· tall cholesterol or triglycerides (a type of thick in the blood);

· a stomach or intestinal disorder;

· a history of suicidal thoughts;

· Parkinson's malady; or

· trouble swallowing.

• FDA pregnancy category C. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.

• Taking antipsychotic medicine during the recent 3 months of pregnancy may reason problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or another problems if you stop taking your medication during pregnancy. If you become pregnant while taking paliperidone, do not stop taking it without your doctor's advice.

• Paliperidone can pass into breast milk and may harm a nursing child. You must not breast-feed while taking paliperidone.

• Older adults may be more likely to have side effects from this medicine.

How must I take paliperidone?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.

• Paliperidone can be taken with or without food.

• Do not crush, chew, or interrupt an extended-release tablet. Swallow it intact. Breaking the pill may reason too many of the drug to be released at one time.

• Use paliperidone regularly to get the most benefit. Get your prescription refilled till you run out of medication completely.

• Your doctor will need to check your progress on a regular basis. Do not miss any scheduled appointments.

• Paliperidone may reason you to have tall blood sugar (hyperglycemia). Conversation to your doctor if you have symptoms of hyperglycemia such as heighten thirst, heighten urination, famine, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, or weight loss. If you are diabetic, check your blood sugar levels on a regular basis while you are taking paliperidone.

• Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose symptoms may include drowsiness, quick heart course, feeling light-headed, fainting, and restless muscle movements in your eyes, tongue, jaw, or neck.

What must I avoid while taking paliperidone?

• Paliperidone may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

• Drinking alcohol can magnify determined side effects of paliperidone.

What are the possible side effects of paliperidone?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Stop using paliperidone and call your doctor at once if you have a serious side effect such as:

· very stiff (rigid) muscles, tall fever, sweating, confusion, quick or uneven heartbeats, feeling like you might pass out;

· restless muscle movements in your eyes, tongue, jaw, or neck;

· tremor (uncontrolled shaking);

· trouble swallowing;

· sudden numbness or weakness, especially on one side of the body;

· sudden and severe headache, or problems with vision, speech, or balance;

· fever, chills, body aches, flu symptoms; or

· white patches or sores internal your mouth or on your lips.

• Smaller serious side effects may include:

· breast swelling or discharge;

· changes in menstrual periods;

· mild restlessness, drowsiness, or tremor;

· blurred vision;

· dizziness or headache;

· weight gain;

· nausea, dry mouth, upset stomach; or

· decreased sex drive, impotence, or difficulty having an orgasm.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect paliperidone?

• The next drugs can interact with paliperidone. Speak your doctor if you are using any of these:

· arsenic trioxide (Trisenox);

· blood pressure medications;

· carbamazepine (Carbatrol, Tegretol);

· droperidol (Inapsine);

· an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), levofloxacin (Levaquin), moxifloxacin (Avelox), or pentamidine (NebuPent, Pentam);

· an antidepressant such as amitriptylline (Elavil, Vanatrip, Limbitrol), clomipramine (Anafranil), or desipramine (Norpramin);

· anti-malaria medications such as chloroquine (Arelan) or mefloquine (Lariam);

· heart rhythm medication such as amiodarone (Cordarone, Pacerone), dofetilide (Tikosyn), disopyramide (Norpace), ibutilide (Corvert), procainamide (Procan, Pronestyl), propafenone (Rythmol), quinidine (Quin-G), or sotalol (Betapace);

· medication to prevent or treat nausea and vomiting, such as dolasetron (Anzemet) or ondansetron (Zofran);

· medicines to treat Parkinson's Malady such as levodopa (Dopar, Larodopa, Sinemet, Atamet, others), bromocriptine (Parlodel, others), pramipexole (Mirapex), or ropinirole (Requip);

· medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), clozapine (FazaClo, Clozaril), haloperidol (Haldol), pimozide (Orap), thioridazine (Mellaril), or ziprasidone (Geodon);

· migraine headache medication such as sumatriptan (Imitrex, Treximet) or zolmitriptan (Zomig); or

· narcotic medicine such as methadone (Methadose, Diskets, Dolophine).

• This list is not complete and another drugs may interact with paliperidone. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about paliperidone.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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