PRAMIPEXOLE

(pram i PEX ole) Brand: Mirapex, Mirapex ER

What is the most significant information I must know about pramipexole?

• Some people taking pramipexole have fallen asleep during usual daytime activities such as working, talking, eating, or driving. You may fall asleep suddenly, even after feeling alert. Speak your doctor if you have any problems with daytime sleepiness or drowsiness. If you are unsure of how this medication will affect you, be careful if you drive or do anything that requires you to be awake and alert.

• You may have heighten sexual urges, unusual urges to gamble, or another intense urges while taking this medicine. Conversation with your doctor if you believe you have any intense or unusual urges while taking pramipexole.

• If you are taking this medicine for rest leg syndrome (RLS), speak your doctor if your symptoms get worse, if they occur in the morning or earlier than normal in the evening, or if you feel restless symptoms in your hands or arms.

• Do not stop using pramipexole without first talking to your doctor. You may need to use smaller and smaller till you stop the medicine completely.

• Avoid getting up too quick from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

• Cool or allergy medication, narcotic pain medication, sleeping pills, muscle relaxers, and medication for seizures, depression or anxiety can add to sleepiness caused by pramipexole. Speak your doctor if you regularly use any of these another medicines.

• Drinking alcohol can magnify determined side effects of pramipexole.

• Pramipexole may reason hallucinations (the sensation of hearing or seeing something that is not there), most commonly among elderly people. Call your doctor if you have hallucinations.

What is pramipexole?

• Pramipexole has some of the same effects as a chemical called dopamine, which occurs naturally in your body. Low levels of dopamine in the brain are associated with Parkinson's disease.

• Pramipexole is used to treat symptoms of Parkinson's malady, such as stiffness, tremors, muscle spasms, and poor muscle control. Pramipexole is also used to treat restless legs syndrome (RLS).

• Pramipexole may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking pramipexole?

• You must not use pramipexole if you are allergic to it.

• To create certain you can safely take pramipexole, speak your doctor if you have any of these another conditions:

· low blood pressure;

· kidney malady; or

· tremors (dyskinesia) or uncontrolled muscle movements.

• You may have heighten sexual urges, unusual urges to gamble, or another intense urges while taking pramipexole. It is not known whether the medication actually causes this effect. Conversation with your doctor if you believe you have any intense or unusual urges while taking pramipexole.

• Some people taking Parkinson's malady medications have developed skin cancer (melanoma). However, people with Parkinson's malady may have a higher risk of melanoma. Conversation to your doctor about this risk and what skin symptoms to watch for. You may need to have regular skin exams.

• FDA pregnancy category C. It is not known whether pramipexole will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.

• It is not known whether pramipexole passes into breast milk or if it could harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

• Pramipexole may reason hallucinations (the sensation of hearing or seeing something that is not there), most commonly among elderly people. Call your doctor if you have hallucinations.

How must I take pramipexole?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your doze to create certain you get the excellent results.

• The doze and timing of pramipexole in treating Parkinson's malady is various from the doze and timing in treating RLS. Follow the directions on your prescription label.

• Pramipexole can be taken with or without food. Take the medicine with food if it upsets your stomach.

• Do not crush, chew, or interrupt an extended-release tablet. Swallow it intact. Breaking the pill may reason too many of the drug to be released at one time.

• If you are taking this medicine for RLS, speak your doctor if your symptoms get worse, if they occur in the morning or earlier than normal in the evening, or if you feel restless symptoms in your hands or arms.

• Do not stop using pramipexole without first talking to your doctor. You may need to use smaller and smaller till you stop the medicine completely.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

What must I avoid while taking pramipexole?

• Pramipexole may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

• Drinking alcohol can magnify determined side effects of pramipexole.

• Avoid getting up too quick from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

What are the possible side effects of pramipexole?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Stop taking pramipexole and call your doctor at once if you have any of these serious side effects:

· extreme drowsiness, falling asleep suddenly, even after feeling alert;

· nausea, sweating, feeling light-headed, fainting;

· hallucinations;

· muscle pain, tenderness, or weakness with fever or flu symptoms and dark colored urine;

· chest pain, cough with white or pink phlegm (mucus), wheezing;

· feeling short of breath (even with mild exertion), swelling, rapid weight gain;

· feeling weak or weary, loss of appetite, rapid weight loss;

· quick or uneven heartbeats; or

· tremors, twitching or uncontrollable movements of your eyes, lips, tongue, person, arms, or legs.

• Smaller serious side effects may include:

· dry mouth, stomach pain, vomiting, constipation;

· headache, dizziness, spinning sensation;

· mild drowsiness;

· swelling in your hands or feet;

· appetite or weight changes;

· blurred vision;

· sleep problems (insomnia), unusual dreams;

· amnesia, forgetfulness, thinking problems; or

· impotence, loss of interest in sex, or trouble having an orgasm.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect pramipexole?

• Cool or allergy medication, sedatives, narcotic pain medication, sleeping pills, muscle relaxers, and medication for seizures, depression or anxiety can add to sleepiness caused by pramipexole. Speak your doctor if you regularly use any of these medicines, or any another medicines for Parkinson's disease.

• Speak your doctor about all another medicines you use, especially:

· amantadine (Symmetrel);

· cimetidine (Tagamet);

· diltiazem (Cardizem, Cartia, Dilacor, Tiazac);

· ranitidine (Zantac);

· quinidine (Quin-G);

· quinine (Qualaquin);

· triamterene (Dyrenium);

· verapamil (Calan, Covera, Isoptin);

· medication to prevent or treat nausea and vomiting, such as metoclopramide (Reglan, Metozolv) or promethazine (Pentazine, Phenergan, Anergan, Antinaus); or

· medication to treat psychiatric disorders, such as chlorpromazine (Thorazine), fluphenazine (Permitil, Prolixin), haloperidol (Haldol), thiothixene (Navane), thioridazine (Mellaril), and others.

• This list is not complete and another drugs may interact with pramipexole. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about pramipexole.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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