IBUPROFEN AND PSEUDOEPHEDRINE

(EYE bue pro fen and SOO doe ee FED rin) Brand: Advil Cool & Sinus, Advil Cool and Sinus Liqui-Gel, Children's Ibuprofen Cool Relief, Dristan Sinus, Motrin Childrens Cold

What is the most significant information I must know about ibuprofen and pseudoephedrine?

• Always ask a doctor till giving a cough or cool medication to a child. Death can occur from the misuse of cough and cool medicines in very young children.

• Do not use ibuprofen and pseudoephedrine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) within the past 14 days.

• Ibuprofen may reason life-threatening heart or circulation problems such as heart onslaught or stroke, especially if you use it long term. Do not use this medicine just till or after heart bypass surgery (coronary artery bypass graft, or CABG).

• Get abnormal medical help if you have chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.

• Ibuprofen may also reason serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning while you are taking ibuprofen, especially in older adults.

• Call your doctor at once if you have symptoms of stomach bleeding such as black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

• Do not take more of this medicine than is recommended. An overdose of ibuprofen can reason hurt to your stomach or intestines.

What is ibuprofen and pseudoephedrine?

• Ibuprofen is nonsteroidal anti-inflammatory drugs (NSAID) that reduces hormones that reason inflammation and pain in the body.

• Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can reason nasal congestion (stuffy nose).

• The combination of ibuprofen and pseudoephedrine is used to treat stuffy nose, sinus congestion, cough, and pain or fever caused by the general cool or flu.

• Ibuprofen and pseudoephedrine may also be used for purposes not listed in this medicine guide.

What must I discuss with my doctor till taking ibuprofen and pseudoephedrine?

• Do not use this medicine just till or after heart bypass surgery (coronary artery bypass graft, or CABG).

• Ibuprofen may reason life-threatening heart or circulation problems such as heart onslaught or stroke, especially if you use it long term.

• You must not use this medicine if you are allergic to ibuprofen or pseudoephedrine, or if you have:

· a stomach ulcer or active bleeding in your stomach or intestines;

· polyps in your nose; or

· a history of allergic reaction to aspirin or another NSAIDs.

• Ask a doctor or pharmacist if it is safety for you to take this medication if you have:

· a history of stomach ulcers or bleeding;

· heart malady, congestive heart failure, tall blood pressure;

· systemic lupus erythematosus (SLE);

· liver or kidney disease;

· a thyroid disorder;

· diabetes;

· enlarged prostate or problems with urination;

· a bleeding or blood clotting mess; or

· if you smoke.

• Taking ibuprofen during the recent 3 months of pregnancy may result in birth defects and prolonged labor and delivery. Do not take this medicine without medical advice if you are pregnant.

• It is not known whether ibuprofen and pseudoephedrine passes into breast milk or if it could harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

How must I take ibuprofen and pseudoephedrine?

• Use exactly as directed on the label, or as predesigned by your doctor. Do not use in larger or less amounts or for longer than recommended. Cool medication is generally taken only for a short time before your symptoms clear up.

• An overdose of ibuprofen can hurt your stomach or intestines. Adults must not take more than 800 milligrams for doze or 3200 mg for day (4 maximum doses).

• Do not give this medicine to a baby younger than 4 years old. Always ask a doctor till giving a cough or cool medication to a child. Death can occur from the misuse of cough and cool medicines in very young children.

• Shake the oral suspension (liquid) well just till you measure a doze. Measure the liquid with a particular dose-measuring spoon or medication cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

• Call your doctor if you have a fever lasting longer than 3 days, if you have new symptoms, or if your condition does not improve after taking this medicine for 7 days.

• If you need surgery, speak the surgeon onward of time that you are using ibuprofen and pseudoephedrine. You may need to stop using the medication for a short time.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Since cool medication is generally taken only as needed, you may not be on a dosing schedule. If you are taking the medicine regularly, take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose symptoms may include nausea, vomiting, stomach pain, dizziness, feeling restless or nervous, blurred vision, sweating, breathing problems, or seizure (convulsions).

What must I avoid while taking ibuprofen and pseudoephedrine?

• Ask a doctor or pharmacist till using any another cough, cool, or pain medication. Ibuprofen and pseudoephedrine are contained in much combination medicines. Taking determined commodity together can reason you to get too many of a determined drug. Check the label to see if a medication contains ibuprofen or pseudoephedrine.

• Avoid drinking alcohol. It may magnify your risk of stomach bleeding.

What are the possible side effects of ibuprofen and pseudoephedrine?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Stop taking this medicine and call your doctor at once if you have a serious side effect such as:

· chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;

· bloody, or tarry stools, coughing up blood or vomit that looks like coffee grounds;

· quick, pounding, or uneven heartbeat;

· severe dizziness, anxiety, restless feeling, or nervousness;

· light bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms;

· dangerously tall blood pressure (severe headache, buzzing in your ears, confusion, chest pain, shortness of breath);

· urinating smaller than normal or not at all;

· skin rash, severe tingling, numbness, pain, muscle weakness; or

· fever, headache, neck stiffness, chills, heighten sensitivity to easy, purple spots on the skin, and/or seizure (convulsions).

• Smaller serious side effects may include:

· upset stomach, nausea, heartburn, diarrhea, constipation;

· bloating, gas, loss of appetite;

· warmth, tingling, or redness under your skin;

· dizziness, headache, feeling excited or restless;

· sleep problems (insomnia); or

· mild itching or skin rash.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect ibuprofen and pseudoephedrine?

• Speak your doctor about all another medicines you use, especially:

· a blood thinner such as warfarin (Coumadin, Jantoven);

· steroids (prednisone and others);

· diuretics (water pills), or medicines to treat tall blood pressure;

· a beta-blocker such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Dutoprol, Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others;

· an antidepressant such as amitriptyline (Elavil, Vanatrip, Limbitrol), doxepin (Sinequan), nortriptyline (Pamelor), and others; or

· aspirin or another NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others.

• This list is not complete and another drugs may interact with ibuprofen and pseudoephedrine. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about ibuprofen and pseudoephedrine.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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