(zole DRO nik AS sid) Brand: Reclast, Zometa
• Zoledronic acid can harm your kidneys. This effect is heighten when you also use another medicines deleterious to the kidneys, such as: chemotherapy, antiviral medicine, pain or arthritis medication, injected antibiotics, or medicines to treat a bowel mess or prevent organ transplant rejection. You may need doze adjustments or particular trials if you use any of these medications.
• Do not receive zoledronic acid without telling your doctor if you have had an allergic reaction to zoledronic acid or similar medication such as alendronate (Fosamax), etidronate (Didronel), ibandronate (Boniva), pamidronate (Aredia), risedronate (Actonel), or tiludronate (Skelid).
• Do not use zoledronic acid if you are pregnant. It could harm the unborn baby.
• Your doctor may recommend you have a dental exam for preventive tooth and gum care till you start your treatment with zoledronic acid. This is especially significant if you have cancer, if you are undergoing chemotherapy or using steroids, or if you have poor dental health.
• Some people using medicines similar to zoledronic acid have developed bone loss in the jaw, also called osteonecrosis of the jaw. Symptoms of this condition may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery inclusion the gums. You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. Another conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia (low red blood cells), and pre-existing dental problems.
• Avoid having any type of dental surgery while you are being treated with zoledronic acid. It may take longer than usual for you to recover.
• Zoledronic acid (sometimes called zoledronate) is in a group of medicines called bisphosphonates (bis FOS fo nayts). Zoledronic acid inhibits the release of calcium from bones.
• Zoledronic acid is used to treat Paget's malady, and tall blood levels of calcium caused by cancer (hypercalcemia of malignancy). Zoledronic acid also treats multiple myeloma (a type of bone marrow cancer) or bone cancer that has spread from elsewhere in the body.
• Zoledronic acid is also used to treat or prevent osteoporosis in postmenopausal women, and to magnify bone mass in men with osteoporosis. Zoledronic acid is used to treat or prevent osteoporosis in people who will be taking determined steroid medicines for 12 months or longer.
• Zoledronic acid may also be used for purposes not listed in this medicine guide.
• You must not receive this medicine if you are allergic to zoledronic acid or similar medication such as alendronate (Fosamax), etidronate (Didronel), ibandronate (Boniva), pamidronate (Aredia), risedronate (Actonel), or tiludronate (Skelid).
• You must also not receive zoledronic acid if you have:
· low levels of calcium in your blood; or
· if you are pregnant or breast-feeding.
• Zometa and Reclast are two various brands of zoledronic acid. You must not be treated with Reclast if you are already receiving Zometa. Till receiving a Reclast injection, speak your doctor if you are already being treated with Zometa.
• Do not use Reclast if you have severe kidney disease.
• To create certain you can safely use zoledronic acid, speak your doctor if you have any of these another conditions:
· a thyroid or parathyroid disorder;
· malabsorption syndrome (an inability to absorb food and nutrients properly);
· a history of surgical removal of part of your intestine;
· bone cancer;
· kidney malady; or
· if you are dehydrated.
• Your doctor may recommend you have a dental exam for preventive tooth and gum care till you start your treatment with zoledronic acid. This is especially significant if you have cancer, if you are undergoing chemotherapy or using steroids, or if you have poor dental health.
• Some people using medicines similar to zoledronic acid have developed bone loss in the jaw, also called osteonecrosis of the jaw. Symptoms of this condition may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery inclusion the gums.
• You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. Another conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia (low red blood cells), and dental surgery or pre-existing dental problems.
• FDA pregnancy category D. Do not use zoledronic acid if you are pregnant. It could harm the unborn child. Use effective birth control, and speak your doctor if you become pregnant during treatment.
• Zoledronic acid can pass into breast milk and may harm a nursing child. Do not receive this medicine without telling your doctor if you are breast-feeding a baby.
• Serious side effects on the kidneys may be more likely in older adults using zoledronic acid.
• Zoledronic acid is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting. Zoledronic acid should be given slowly, and the IV infusion can take at least 15 minutes to complete.
• Zoledronic acid is sometimes given only once for year. Follow your doctor's instructions.
• Drink at least 2 glasses of water within a little hours till your injection to hold from getting dehydrated.
• Your doctor may want you to take a calcium and/or vitamin D supplement while you are being treated with zoledronic acid. Carefully follow your doctor's instructions about the type and power of calcium to take.
• To be certain this medication is helping your condition and is not causing deleterious effects, your blood will need to be tested often. Your kidney function may also need to be tested. You may not need to use zoledronic acid for longer than 3 to 5 years if you use it for osteoporosis. Visit your doctor regularly.
• Call your doctor for instructions if you miss an appointment for your zoledronic acid injection.
• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.
• Overdose symptoms may include numbness or tingling in your hands and foots, muscle stiffness, spasms in the muscles of your person, uneven heartbeats, and wheezing or trouble breathing.
• Avoid having any type of dental surgery while you are being treated with zoledronic acid. It may take longer than usual for you to recover.
• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.
• Call your doctor at once if you have a serious side effect such as:
· urinating smaller than normal or not at all;
· drowsiness, confusion, mood changes, heighten thirst, loss of appetite, nausea and vomiting;
· swelling, weight gain, feeling short of breath;
· muscle spasms, numb or tingly feeling (especially near your mouth);
· fever, chills, body aches, flu symptoms;
· pale skin, light bruising, unusual weakness;
· feeling like you might pass out;
· severe joint, bone, or muscle pain;
· new or unusual pain in your thigh or hip; or
· bronchospasm (wheezing, chest tightness, trouble breathing).
• Smaller serious side effects may include:
· cough;
· vision problems;
· diarrhea, constipation;
· headache, weary feeling;
· mild joint or muscle pain; or
· redness or swelling where the needle was placed.
• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.
• Zoledronic acid can harm your kidneys. This effect is heighten when you also use another medicines deleterious to the kidneys. You may need doze adjustments or particular trials if you have recently used:
· a diuretic (water pill);
· lithium (Eskalith, Lithobid);
· methotrexate (Rheumatrex, Trexall);
· pain or arthritis medicines such as aspirin (Anacin, Excedrin), acetaminophen (Tylenol), ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others;
· medicines used to treat ulcerative colitis, such as mesalamine (Pentasa) or sulfasalazine (Azulfidine);
· medication used to prevent organ transplant rejection, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune) or tacrolimus (Prograf);
· IV antibiotics such as amphotericin B (Amphotec, AmBisome, Abelcet), amikacin (Amikin), bacitracin (Baci IM), capreomycin (Capastat), gentamicin (Garamycin), kanamycin (Kantrex), streptomycin, or vancomycin (Vancocin, Vancoled);
· antiviral medicines such as adefovir (Hepsera), cidofovir (Vistide), or foscarnet (Foscavir); or
· cancer medication such as aldesleukin (Proleukin), carmustine (BiCNU, Gliadel), cisplatin (Platinol), ifosfamide (Ifex), oxaliplatin (Eloxatin), streptozocin (Zanosar), or tretinoin (Vesanoid).
• This list is not complete and another drugs may interact with zoledronic acid. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.
• Your doctor or pharmacist can provide more information about zoledronic acid.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
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