IBANDRONATE (ORAL/INJECTION)

(eye BAN dro nate) Brand: Boniva

What is the most significant information I must know about ibandronate?

• You must not use this medicine if you are allergic to ibandronate, or if you have severe kidney malady, low blood levels of calcium (hypocalcemia), or a problem with your esophagus (the pipe that connects your mouth and stomach).

• Do not take an ibandronate tablet if you can't sit upright or stand for at least one full hour. Ibandronate can reason serious problems in the stomach or esophagus. You will need to remain upright for at least 60 minutes after taking this medication.

What is ibandronate?

• Ibandronate is in the group of medicines called bisphosphonates (bis FOS fo nayts). It alters the cycle of bone formation and breakdown in the body. Ibandronate slows bone loss while increasing bone mass, which may prevent bone fractures.

• Ibandronate is used to treat or prevent osteoporosis in women after menopause.

• Ibandronate may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till using ibandronate?

• To create certain ibandronate is safety for you, speak your doctor if you have:

· a vitamin D deficiency;

· kidney disease;

· an ulcer in your stomach or esophagus; or

· trouble swallowing.

• In rare cases, this medication may reason bone loss (osteonecrosis) in the jaw. Symptoms include jaw pain or numbness, red or swollen gums, loose teeth, or slow healing after dental work. The longer you use ibandronate, the more likely you are to develop this condition.

• Osteonecrosis of the jaw may be more likely if you have cancer or received chemotherapy, radiation, or steroids. Another risk factors include blood clotting disorders, anemia (low red blood cells), and a pre existing dental problem.

• FDA pregnancy category C. It is not known whether ibandronate will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.

• It is not known whether ibandronate passes into breast milk or if it could harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

How must I use ibandronate?

• Follow all directions on your prescription label. Do not use this medication in larger or less amounts or for longer than recommended.

• Ibandronate tablets are taken either once every day or once every month. Ibandronate intravenous solution is given as an injection into one of your veins once each three (3) months. A healthcare provider will give you this injection. Ibandronate tablets can be taken at home.

• Take the ibandronate tablet first thing in the morning, at least 1 hour (60 minutes) till you ate or drink anything or take any another medication. If you take an ibandronate tablet only once a month, take it on the same day every month and always first thing in the morning.

• Take every ibandronate tablet with a full glass (6 to 8 ounces) of water. Use only plain water (not mineral water) when taking an ibandronate tablet.

• Do not crush, chew, or suck the ibandronate tablet. Swallow the pill whole.

• After taking an ibandronate tablet, carefully follow these instructions:

· Do not lie down or recline for at least 60 minutes after taking ibandronate.

· Do not ate or drink anything another than plain water.

· Do not take any another medicines including vitamins, calcium, or antacids for at least 60 minutes after taking ibandronate. It may be excellent to take your another medicines at a various time of the day. Conversation with your doctor about the excellent dosing schedule for your another medicines.

• To be certain this medicine is helping your condition, your bone mineral density will need to be tested often. You may not need to take ibandronate for longer than 3 to 5 years.

• If you need to have any dental work (especially surgery), speak the dentist onward of time that you are using ibandronate. You may need to stop using the medication for a short time.

• Ibandronate is only part of a complete program of treatment that may also include diet changes, exercice, and taking calcium and vitamin supplements. Follow your diet, medicine, and exercice routines very closely.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• If you take ibandronate tablets once daily: If you forget to take this medication first thing in the morning, do not take it later in the day. Wait before the next morning to take the medication and skip the missed doze. Do not take two (2) tablets in one day.

• If you take ibandronate tablets once a month: If you forget to take ibandronate on your scheduled day, take it first thing in the morning on the day after you remember the missed doze. Then return to your regular monthly schedule on your chosen doze day. If your following scheduled doze is smaller than 7 days away, wait before then to take the medication and skip the missed doze. Do not take two (2) tablets in one week.

• If you receive ibandronate injections each 3 months: Call your doctor for instructions if you miss an appointment for your injection.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222. Drink a full glass of milk and call your local poison control center or abnormal room right away. Do not create yourself vomit and do not lie down.

• Overdose symptoms may include nausea, heartburn, stomach pain, diarrhea, muscle cramps, numbness or tingling, tight muscles in your person, seizure (convulsions), irritability, and unusual thoughts or behavior.

What must I avoid while taking ibandronate?

• Do not take any another medicines including vitamins, calcium, or antacids for at least 60 minutes till or after taking an ibandronate tablet.

• Avoid milk and another dairy commodity for at least 60 minutes after taking ibandronate (except in the case of overdose as stated above).

What are the possible side effects of ibandronate?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Stop using ibandronate and call your doctor at once if you have:

· chest pain, new or worsening heartburn;

· difficulty or pain when swallowing;

· pain or burning under the ribs or in the back;

· severe joint, bone, or muscle pain;

· new or unusual pain in your thigh or hip; or

· jaw pain, numbness, or swelling.

• General side effects may include:

· back pain, headache;

· redness or swelling of your eyes;

· diarrhea;

· flu symptoms;

· redness or swelling where the medication was injected;

· nausea or upset stomach; or

· pain in your arms or legs.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect ibandronate?

• Speak your doctor about all medicines you use, and those you start or stop using during your treatment with ibandronate, especially:

· aspirin or another NSAIDs (nonsteroidal anti-inflammatory drugs)--ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

• This list is not complete. Another drugs may interact with ibandronate, including prescription and over-the-counter medicines, vitamins, and herbal commodity. Not all possible interactions are listed in this medicine manual.

Where can I get more information?

• Your pharmacist can provide more information about ibandronate.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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