THIOGUANINE
(THYE oh GWA neen) Brand: Tabloid
What is the most significant information I must know about thioguanine?
• Do not use thioguanine if you are pregnant. It could harm the unborn baby.
• You must not use thioguanine if you are allergic to it, or if you have ever used thioguanine or mercaptopurine (Purinethol) and they were not effective in treating your condition.
• Till taking thioguanine, speak your doctor if you have liver or kidney malady, or any type of infection.
• Stop taking this medicine and call your doctor at once if you have light bruising or bleeding, fever, flu symptoms, mouth sores, dark urine, upper stomach pain, jaundice (yellowing of the skin or eyes), or ongoing diarrhea.
• Thioguanine can lower blood cells that help your body fight infections. Your blood cells, kidney function, and liver function may need to be tested often. Your cancer treatments may be delayed based on the results of these trials. Do not miss any follow up visits to your doctor for blood or urine tests.
What is thioguanine?
• Thioguanine is a cancer medicine that interferes with the growth and spread of cancer cells in the body.
• Thioguanine is used to treat determined types of leukemia. Thioguanine is sometimes given with another cancer medications.
• Thioguanine may also be used for purposes not listed in this medicine guide.
What must I discuss with my healthcare provider till taking thioguanine?
• You must not use thioguanine if you are allergic to it, or if you have ever used thioguanine or mercaptopurine (Purinethol) and they were not effective in treating your condition.
• To create certain you can safely take thioguanine, speak your doctor if you have any of these another conditions:
· liver disease;
· kidney malady; or
· any type of viral, bacterial, or fungal infection.
• FDA pregnancy category D. Do not use thioguanine if you are pregnant. It could harm the unborn child. Use effective birth control, and speak your doctor if you become pregnant during treatment.
• It is not known whether thioguanine passes into breast milk or if it could harm a nursing child. You must not breast-feed while taking thioguanine.
How must I take thioguanine?
• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.
• Your doctor may occasionally change your doze to create certain you get the excellent results.
• Thioguanine can lower blood cells that help your body fight infections. Your blood cells, kidney function, and liver function may need to be tested often. Your cancer treatments may be delayed based on the results of these trials. Do not miss any follow up visits to your doctor for blood or urine tests.
• Store at room temperature away from moisture and heat.
What happens if I miss a dose?
• Contact your doctor if you miss a doze of thioguanine.
What happens if I overdose?
• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.
• Overdose symptoms may include some of the serious side effects listed in this medicine guide.
What must I avoid while taking thioguanine?
• Avoid being around people who are sick or have infections. Speak your doctor at once if you develop signs of infection.
• This medication can pass into body fluids (including urine, feces, vomit, semen, vaginal fluid). For at least 48 hours after you receive a doze, avoid allowing your body fluids to come into contact with your hands or another surfaces. Patients and caregivers must wear rubber gloves while cleaning up body fluids, handling contaminated trash or laundry or changing diapers. Wash hands till and after removing gloves. Wash soiled clothing and linens apart from another laundry.
• Body fluids must not be handled by a woman who is pregnant or who may become pregnant. Use condoms during sexual activity to avoid exposure to body fluids.
• Do not receive a live vaccine while using thioguanine. The vaccine may not work as well during this time, and may not fully protect you from malady. Live vaccines include measles, mumps, rubella (MMR), oral polio, rotavirus, typhoid, varicella (chickenpox), H1N1 influenza, and nasal flu vaccine.
What are the possible side effects of thioguanine?
• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.
• Stop using thioguanine and call your doctor at once if you have any of these serious side effects:
· pale skin, feeling light-headed or short of breath, rapid heart course, trouble concentrating;
· fever, chills, body aches, flu symptoms, sores or white patches in your mouth and throat;
· light bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
· severe vomiting, ongoing diarrhea;
· severe pain in your upper stomach spreading to your back, quick heart rate;
· bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; or
· nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
• Smaller serious side effects may include:
· vomiting, mild diarrhea;
· hair loss;
· mild itching or skin rash; or
· darkened skin color.
• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.
What another drugs will affect thioguanine?
• Speak your doctor about all another cancer treatments you are receiving. Also speak your doctor about all another medicines you use, especially:
· auranofin;
· azathioprine;
· cyclosporine;
· methotrexate;
· olsalazine, mesalamine or sulfasalazine;
· sulfamethoxazole and trimethoprim;
· birth control pills or hormone replacement therapy;
· a blood thinner such as warfarin;
· tuberculosis medications;
· cholesterol medications such as niacin, atorvastatin, simvastatin, lovastatin, pravastatin and others;
· an NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen, naproxen, diclofenac, etodolac, indomethacin, ketoprofen and others; or
· an ACE inhibitor such as benazepril, enalapril, lisinopril, quinapril, ramipril and others;
· an antibiotic such as dapsone, erythromycin or rifampin;
· antifungal medicine such as fluconazole, itraconazole, or ketoconazole;
· seizure medications such as carbamazepine, phenytoin, felbamate, valproic acid; or
· HIV/AIDS medications such as abacavir/lamivudine/zidovudine, lamivudine, nevirapine, tenofovir or zidovudine;
• This list is not complete and another drugs may interact with thioguanine. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.
Where can I get more information?
• Your doctor or pharmacist can provide more information about thioguanine.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
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