TENOFOVIR

(ten OF oh vir) Brand: Viread

What is the most significant information I must know about tenofovir?

• Do not take tenofovir together with adefovir (Hepsera), or with combination medicines that contain tenofovir (Atripla, Complera, Stribild, or Truvada).

• This medication may reason a serious condition called lactic acidosis. Get abnormal medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cool feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, quick or uneven heart course, dizziness, or feeling very weak or weary.

• Tenofovir can also reason severe or life-threatening effects on your liver. Call your doctor at once if you have any of these symptoms while taking tenofovir: nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

What is tenofovir?

• Tenofovir is an antiviral medicine that prevents human immunodeficiency virus (HIV) or hepatitis B virus cells from multiplying in your body.

• Tenofovir is used to treat HIV, which causes the acquired immunodeficiency syndrome (AIDS). Tenofovir is not a cure for HIV or AIDS. Tenofovir is also used to treat chronic hepatitis B.

• Tenofovir may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking tenofovir?

• You must not take tenofovir if you are allergic to it. Do not take tenofovir together with adefovir (Hepsera), or with combination medicines that contain tenofovir (Atripla, Complera, Stribild, or Truvada).

• Tenofovir must not be given to a baby with HIV who is younger than 2 years old. Tenofovir must not be used to treat hepatitis B in a baby younger than 12 years old.

• To create certain tenofovir is safety for you, speak your doctor if you have:

· liver malady (especially hepatitis B if you also have HIV);

· kidney malady; or

· low bone mineral density.

• Some people develop a life-threatening condition called lactic acidosis while taking tenofovir. You may be more likely to develop lactic acidosis if you are overweight or have liver malady, if you are a woman, or if you have taken HIV or AIDS medications for a long time. Conversation with your doctor about your individual risk.

• FDA pregnancy category B. This medicine is not expected to be deleterious to an unborn child, but HIV can be passed to your child if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection.

• Tenofovir can pass into breast milk and may harm a nursing child. You must not breast-feed while you are using tenofovir to treat hepatitis B. Women with HIV or AIDS must not breast feed a child. Even if your child is born without HIV, the virus may be passed to the child in your breast milk.

How must I take tenofovir?

• Till you start treatment with tenofovir, your doctor may perform trials to create certain you do not have HIV (if you are being treated for hepatitis B) or hepatitis B (if you are being treated for HIV).

• Follow all directions on your prescription label. Do not take this medication in larger or less amounts or for longer than recommended.

• Tenofovir tablets may be taken with or without food.

• Tenofovir oral powder must be taken with food. Mix the powder with soft food such as applesauce, yogurt, or child food. Do not mix tenofovir oral powder with liquid.

• If a baby is taking this medicine, speak your doctor if the baby has any changes in weight. Tenofovir doses are based on weight in children.

• This medicine comes with patient instructions for safety and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

• While using tenofovir, you may need frequent blood trials. Your liver and kidney function may also need to be checked.

• Use tenofovir regularly to get the most benefit. Get your prescription refilled till you run out of medication completely.

• HIV/AIDS is generally treated with a combination of drugs. Use all medications as directed by your doctor. Read the medicine manual or patient instructions provided with every medicine. Do not change your doses or medicine schedule without your doctor's advice. Each face with HIV or AIDS must stay under the care of a doctor.

• Store at room temperature away from moisture and heat. Hold the bottle tightly closed when not in use.

• If you have hepatitis B you may develop liver symptoms after you stop taking this medicine, even months after stopping. Your doctor may want to check your liver function for different months after you stop using tenofovir. Visit your doctor regularly.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

What must I avoid while taking tenofovir?

• Avoid drinking alcohol. It may magnify your risk of liver damage.

• Taking this medicine will not prevent you from passing HIV to another people. Avoid having unprotected sex or sharing razors or toothbrushes. Conversation with your doctor about safety ways to prevent HIV transmission during sex. Sharing drug or medication needles is never safety, even for a healthy person.

What are the possible side effects of tenofovir?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Early symptoms of lactic acidosis may get worse over time and this condition can be fatal. Get abnormal medical help if you have even mild symptoms: muscle pain or weakness, numb or cool feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, quick or uneven heart course, dizziness, or feeling very weak or weary.

• Call your doctor at once if you have:

· sore throat, flu symptoms, light bruising or unusual bleeding;

· kidney problems - heighten thirst and urination, loss of appetite, constipation, few or no urinating; or

· liver problems--nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

• Tenofovir may magnify your risk of determined infections or autoimmune disorders by changing the way your immune system works. Symptoms may occur weeks or months after you start treatment with tenofovir. Speak your doctor if you have:

· signs of a new infection--fever, night sweats, swollen glands, mouth sores, diarrhea, stomach pain, weight loss;

· chest pain (especially when you breathe), dry cough, wheezing, feeling short of breath;

· cool sores, sores on your genital or anal area;

· rapid heart course, feeling anxious or irritable, weakness or prickly feeling, problems with balance or eye movement;

· trouble speaking or swallowing, severe lower back pain, loss of bladder or bowel control; or

· swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence, loss of interest in sex.

• General side effects may include:

· mild nausea or stomach pain, mild diarrhea;

· depression, headache, dizziness, mild weakness;

· sleep problems (insomnia);

· mild itching or rash; or

· changes in the shape or location of body thick (especially in your arms, legs, person, neck, breasts, and waist).

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect tenofovir?

• Tenofovir can harm your kidneys. This effect is heighten when you also use determined another medicines, including: antivirals, chemotherapy, injected antibiotics, medication for bowel disorders, medication to prevent organ transplant rejection, and some pain or arthritis medicines (including aspirin, Tylenol, Advil, and Aleve).

• Speak your doctor about all medicines you use, and those you start or stop using during your treatment with tenofovir, especially another HIV or AIDS medications, such as:

· atazanavir;

· didanosine; or

· lopinavir and ritonavir.

• This list is not complete. Another drugs may interact with tenofovir, including prescription and over-the-counter medicines, vitamins, and herbal commodity. Not all possible interactions are listed in this medicine manual.

Where can I get more information?

• Your pharmacist can provide more information about tenofovir.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.