ISONIAZID, PYRAZINAMIDE, AND RIFAMPIN

(EYE soe NYE a zid, PIR a ZIN a mide, and rif AM pin) Brand: Rifater

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What is the most significant information I must know about isoniazid, pyrazinamide, and rifampin?

• Take this medicine for the full predesigned length of time. Your symptoms may get better till your infection is completely cleared. Isoniazid, pyrazinamide, and rifampin will not treat a viral infection such as the general cool or flu.

• Avoid drinking alcohol while taking isoniazid, pyrazinamide, and rifampin. Alcohol may magnify your risk of liver damage.

Isoniazid, pyrazinamide, and rifampin can create birth control pills smaller effective. Ask your doctor about using a various method of birth control while taking isoniazid, pyrazinamide, and rifampin.

• Avoid foods that are tall in tyramine, listed in the "What must I avoid while taking isoniazid, pyrazinamide, and rifampin?" section of this leaflet. Tyramine can interact with this medicine and reason unpleasant side effects.

What is isoniazid, pyrazinamide, and rifampin?

Isoniazid, pyrazinamide, and rifampin are antibiotics. They prevent tuberculous bacteria from multiplying in your body.

• The combination of isoniazid, pyrazinamide, and rifampin is used to treat tuberculosis (TB).

Isoniazid, pyrazinamide, and rifampin may also be used for another purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking isoniazid, pyrazinamide, and rifampin?

• You must not use this medicine if you are allergic to isoniazid, pyrazinamide, or rifampin (Rifamate, Rifadin, Rimactane), or if you have:

· severe liver disease;

· active gout; or

· if you have ever had drug fever, chills, and arthritis caused by taking this medication.

• If you have any of these another conditions, you may need a doze adjustment or particular trials to safely use isoniazid, pyrazinamide, and rifampin:

· kidney disease;

· liver disease;

· HIV;

· porphyria;

· gout;

· diabetes; or

· if you drink alcohol daily.

• FDA pregnancy category C. It is not known whether isoniazid, pyrazinamide, and rifampin is deleterious to an unborn child. Till taking this medicine, speak your doctor if you are pregnant or plan to become pregnant during treatment.

Isoniazid, pyrazinamide, and rifampin can create birth control pills smaller effective. Ask your doctor about using a various method of birth control to prevent pregnancy while taking isoniazid, pyrazinamide, and rifampin.

Isoniazid, pyrazinamide, and rifampin can pass into breast milk and may harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

How must I take isoniazid, pyrazinamide, and rifampin?

• Take this medicine exactly as predesigned by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

• Take this medication with a full glass (8 ounces) of water.

• Take isoniazid, pyrazinamide, and rifampin on an empty stomach, at least 1 hour till or 2 hours after a meal.

• Take this medicine for the full predesigned length of time. Your symptoms may get better till your infection is completely cleared. Isoniazid, pyrazinamide, and rifampin will not treat a viral infection such as the general cool or flu.

• To be certain this medicine is not causing deleterious effects, your liver function will need to be checked with blood trials on a regular basis. You may also need routine eye exams during treatment. Do not miss any follow-up visits to your doctor.

• This medicine can reason you to have unusual results with determined medical trials. Speak any doctor who treats you that you are taking isoniazid, pyrazinamide, and rifampin.

• Store this medicine at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. If it is nearly time for your following doze, wait before then to take the medication and skip the missed doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention if you think you have used too many of this medicine.

• Overdose symptoms may include nausea, vomiting, slurred speech, hallucinations, and seizure.

What must I avoid while taking isoniazid, pyrazinamide, and rifampin?

• Avoid drinking alcohol while taking isoniazid, pyrazinamide, and rifampin. Alcohol may magnify your risk of liver damage.

• If you take an antacid, avoid taking it within 1 hour after you have taken isoniazid, pyrazinamide, and rifampin. Antacids can create it harder for your body to absorb rifampin.

• Antibiotic medicines can reason diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, stop taking this medicine and call your doctor. Do not use any medication to stop the diarrhea unless your doctor has told you to.

Certain foods can interact with isoniazid, pyrazinamide, and rifampin, causing unpleasant side effects. Avoid foods that are tall in tyramine, including:

· avocados, bananas, figs, raisins, and sauerkraut;

· beef or chicken liver, fish, meats prepared with tenderizer, bologna, pepperoni, salami, summer sausage, game meat, meat extracts, caviar, dried fish, herring, and shrimp paste;

· beer (alcoholic and nonalcoholic), red wine (especially Chianti), sherry, vermouth, and another distilled spirits;

· caffeine (including coffee, tea, cola); and

· cheeses, including American, blue, boursault, brick, brie, camembert, cheddar, emmenthaler, gruyere, mozzarella, parmesan, romano, roquefort, stilton, and Swiss;

· chocolate;

· ginseng;

· sour cream and yogurt;

· soy sauce, miso soup, bean curd, fava beans; or

· yeast extracts.

• Do not wear soft contact lenses while taking isoniazid, pyrazinamide, and rifampin. This medication may turn determined body fluids a red color (including tears, saliva, urine, and sweat). While this is a harmless side effect, it may permanently stain contact lenses.

What are the possible side effects of isoniazid, pyrazinamide, and rifampin?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

Isoniazid, pyrazinamide, and rifampin can reason severe liver symptoms. Stop taking this medicine and call your doctor at once if you have any of these liver symptoms:

· low fever;

· nausea, stomach pain, loss of appetite;

· dark urine, clay-colored stools; or

· jaundice (yellowing of the skin or eyes).

• Call your doctor at once if you have any another serious side effects such as:

· fever, chills, body aches, flu symptoms, weakness, sores in your mouth and throat;

· pale skin, light bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;

· feeling short of breath, feeling like you might pass out;

· cough, chest pain or tightness;

· diarrhea that is watery or bloody;

· vision problems;

· urinating smaller than normal or not at all; or

· drowsiness, mood changes, heighten thirst, swelling, weight gain.

• Smaller serious side effects may include:

· mild stomach pain, heartburn, diarrhea;

· mild rash or itching;

· muscle or joint pain;

· drowsiness, dizziness, spinning sensation;

· ringing in your ears; or

· numbness or tingling in your legs.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect isoniazid, pyrazinamide, and rifampin?

• Much drugs can interact with isoniazid, pyrazinamide, and rifampin. Adown is just a partial list. Speak your doctor if you are using:

· cyclosporine (Gengraf, Neoral, Sandimmune);

· haloperidol (Haldol);

· nortriptyline (Pamelor),

· probenecid (Benemid);

· theophylline (Elixophyllin, Theo-24, Uniphyl);

· an antibiotic such as ciprofloxacin (Cipro), clarithromycin (Biaxin), dapsone, erythromycin (E.E.S., Erythrocin, Ery-Tab), and others;

· antifungal medicine such as fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral);

· a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton);

· birth control pills or hormone replacement therapy;

· a blood thinner such as warfarin (Coumadin);

· diabetes medications you take by mouth;

· heart or blood pressure medicine such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), digoxin (Lanoxin), diltiazem (Cartia, Cardizem), metoprolol (Toprol), propranolol (Inderal), nifedipine (Procardia), verapamil (Covera, Isoptin, Verelan), and others;

· heart rhythm medicine such as disopyramide (Norpace), mexiletine (Mexitil), quinidine (Quinaglute, Quinidex, Quin-Release);

· narcotic medications such as buprenorphine (Buprenex, Subutex), fentanyl (Actiq, Duragesic, Fentora), methadone (Dolophine, Methadose);

· a sedative such as diazepam (Valium);

· seizure medicine such as carbamazepine (Carbatrol, Tegretol), phenytoin (Dilantin), primidone (Mysoline), valproic acid (Depakene);

· a steroid such as prednisolone; or

· a sulfa drug (Cotrim, Bactrim, Septra, SMX-TMP, and others).

There are much another medicines that can interact with isoniazid, pyrazinamide, and rifampin. Speak your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal commodity, and drugs predesigned by another doctors. Do not start using a new medicine without telling your doctor. Hold a list of all the medicines you use and show this list to any doctor or another healthcare provider who treats you.

Where can I get more information?

• Your pharmacist can provide more information about isoniazid, pyrazinamide, and rifampin.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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