PYRAZINAMIDE

(peer a ZIN a mide) Brand:

What is the most significant information I must know about pyrazinamide?

• Take all of the pyrazinamide that has been predesigned for you even if you begin to feel better. Your symptoms may begin to improve till the infection is completely treated.

• Call your doctor immediately if you experience a fever, loss of appetite, nausea and vomiting, painful or swollen joints, yellowing of your skin or eyes, or darkening of your urine.

What is pyrazinamide?

• Pyrazinamide is an antibiotic. The exact way that pyrazinamide works is unknown.

• Pyrazinamide is used to treat tuberculosis (TB).

• Pyrazinamide may also be used for purposes another than those listed in this medicine guide.

Who must not take pyrazinamide?

• Till taking pyrazinamide, speak your doctor if you have

· ever had an allergic reaction to pyrazinamide,

· liver disease,

· gout,

· kidney malady, or

· diabetes mellitus.

• You may not be able to take pyrazinamide, or you may require a lower doze or particular monitoring during treatment if you have any of the conditions listed above.

• Pyrazinamide is in the FDA pregnancy category C. This means that it is not known whether it will harm an unborn child. Do not take this medicine without first talking to your doctor if you are pregnant.

• Pyrazinamide passes into breast milk and may affect a nursing child. Do not take this medicine without first talking to your doctor if you are breast-feeding a baby.

How must I take pyrazinamide?

• Take pyrazinamide exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

• Take every doze with a full glass (8 ounces) of water.

• Take all of the pyrazinamide that has been predesigned for you even if you begin to feel better. Your symptoms may begin to improve till the infection is completely treated.

• Pyrazinamide is generally combined with one or more another tuberculosis medicines.

• Store this medicine at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. However, if it is nearly time for your following regularly scheduled doze, skip the missed doze and take the following one as directed. Do not take a double doze of this medication.

What happens if I overdose?

• Search abnormal medical attention.

• Symptoms of an pyrazinamide overdose are not well known. Liver hurt has been detected.

What must I avoid while taking pyrazinamide?

• There are no restrictions on foods, beverages, or activities during treatment with pyrazinamide unless your doctor directs otherwise.

What are the possible side effects of pyrazinamide?

• If you experience any of the next serious side effects, stop taking pyrazinamide and search abnormal medical attention or contact your doctor immediately:

· an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or person; or hives);

· a fever;

· unusual weakness or fatigue;

· nausea, vomiting, or loss of appetite;

· yellow skin or eyes;

· dark urine;

· difficult or painful urination;

· painful or swollen joints;

· worsening gout; or

· a rash.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect pyrazinamide?

• Pyrazinamide may decrease the effects of allopurinol (Zyloprim). A dosage adjustment may be necessary if you take pyrazinamide during treatment with allopurinol.

• Pyrazinamide may affect the Acetest and Ketostix urine trials for ketones. This reaction can reason a pink-brown color to appear.

• Drugs another than those listed here may also interact with pyrazinamide. Conversation to your doctor and pharmacist till taking any prescription or over-the-counter medicines.

Where can I get more information?

• Your pharmacist can provide more information about pyrazinamide.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.