IBUPROFEN AND OXYCODONE

(eye byoo PROE fen and ox i KOE done) Brand: Combunox

What is the most significant information I must know about ibuprofen and oxycodone?

• This medication may reason life-threatening heart or circulation problems such as heart onslaught or stroke, especially if you use it long term. Do not use ibuprofen and oxycodone just till or after heart bypass surgery (coronary artery bypass graft, or CABG). Get abnormal medical help if you have chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.

• This medication may also reason serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning while you are taking ibuprofen and oxycodone, especially in older adults. Call your doctor at once if you have symptoms of stomach bleeding such as black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

• Oxycodone may be habit-forming and should be used only by the face it was predesigned for. Hold the medicine in a secure seat where others can't get to it.

• Avoid drinking alcohol. It may magnify your risk of stomach bleeding.

• Speak your doctor if the medication seems to stop working as well in relieving your pain.

What is ibuprofen and oxycodone?

• Oxycodone is an opioid pain medicine. An opioid is sometimes called a narcotic.

• Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). Ibuprofen works by reducing hormones that reason inflammation and pain in the body.

• The combination of ibuprofen and oxycodone is used short-term to relieve temperate to severe pain.

• Ibuprofen and oxycodone may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking ibuprofen and oxycodone?

• You must not use this medicine if you have severe or uncontrolled asthma, or a stomach condition called paralytic ileus. Do not use ibuprofen and oxycodone just till or after heart bypass surgery (coronary artery bypass graft, or CABG).

• Oxycodone may be habit forming and must be used only by the face it was predesigned for. Never share this medicine with other face, especially somebody with a history of drug abuse or addiction. Hold the medicine in a seat where others can't get to it.

• Ibuprofen may reason life-threatening heart or circulation problems such as heart onslaught or stroke, especially if you use it long term.

• Do not use this medicine if you are allergic to oxycodone or ibuprofen (Advil, Motrin), or another NSAIDs such as aspirin, Aleve, Celebrex, Orudis, Indocin, Lodine, Voltaren, Toradol, Mobic, Relafen, Feldene, and others.

• To create certain you can safely take ibuprofen and oxycodone, speak your doctor if you have any of these another conditions:

· heart malady, congestive heart failure, tall blood pressure, or a history of heart onslaught, stroke, or blood clot;

· asthma or another breathing disorders;

· liver or kidney disease;

· a history of head injury or brain tumor;

· epilepsy or another seizure disorder;

· stomach or intestinal mess, history of stomach ulcer or bleeding;

· underactive thyroid, a pancreas mess, or Addison's malady or another adrenal gland disorder;

· curvature of the spine;

· an enlarged prostate or problems with urination; or

· mental diseases or a history of drug or alcohol addiction.

• FDA pregnancy category D. Oxycodone may reason breathing problems and addiction or withdrawal symptoms in a newborn if the mother takes the medicine during pregnancy. Taking ibuprofen during the recent 3 months of pregnancy may harm the unborn baby. Speak your doctor if you are pregnant or plan to become pregnant while using ibuprofen and oxycodone.

• Ibuprofen and oxycodone may pass into breast milk and could harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

• Older adults may be more sensitive to the effects of this medicine.

How must I take ibuprofen and oxycodone?

• Take exactly as predesigned. Never take ibuprofen and oxycodone in larger amounts, or for longer than recommended by your doctor. Follow the directions on your prescription label. Speak your doctor if the medication seems to stop working as well in relieving your pain.

• Drink 6 to 8 full glasses of water daily to help prevent constipation while you are taking ibuprofen and oxycodone. Ask your doctor about ways to magnify the fiber in your diet. Do not use a stool softener (laxative) without first asking your doctor.

• If you need surgery, speak the surgeon onward of time that you are using ibuprofen and oxycodone.

• Store at room temperature away from moisture and heat.

• Hold track of the amount of medication used from every new bottle. Ibuprofen and oxycodone is a drug of abuse and you must be aware if anyone is using your medication improperly or without a prescription.

What happens if I miss a dose?

• Since ibuprofen and oxycodone is taken as needed, you may not be on a dosing schedule. If you are taking the medicine regularly, take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222. An overdose of ibuprofen and oxycodone can be fatal.

• Overdose symptoms may include extreme drowsiness, nausea, vomiting, dark urine, jaundice (yellowing of the skin or eyes), black or bloody stools, coughing up blood, urinating smaller than normal or not at all, confusion, ringing in your ears, pinpoint pupils, weak pulse, slow heart course, fainting, blue lips, shallow breathing.

What must I avoid while taking ibuprofen and oxycodone?

• This medicine may impair your thinking or reactions. Avoid driving or operating machinery before you know how ibuprofen and oxycodone will affect you.

• Ask a doctor or pharmacist till using any another cool, allergy, or pain medication. Ibuprofen is contained in much combination medicines. Taking determined commodity together can reason you to get too many ibuprofen. Check the label to see if a medication contains ibuprofen.

• Avoid drinking alcohol. It may magnify your risk of stomach bleeding.

What are the possible side effects of ibuprofen and oxycodone?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Stop using ibuprofen and oxycodone and call your doctor at once if you have a serious side effect such as:

· chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;

· black, bloody, or tarry stools, coughing up blood or vomit that looks like coffee grounds;

· swelling or rapid weight gain;

· shallow breathing, slow heartbeat;

· confusion, feeling light-headed, fainting;

· light bruising or bleeding;

· nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

· severe blistering, peeling, and red skin rash; or

· fever, headache, neck stiffness, chills, heighten sensitivity to easy, purple spots on the skin, and/or seizure (convulsions).

• Smaller serious side effects include:

· headache, dizziness, drowsiness;

· mild nausea, vomiting, upset stomach, bloating, gas, constipation, diarrhea;

· blurred vision; or

· dry mouth.

• This is not a complete list of side effects and others may occur. Speak your doctor about any unusual or bothersome side effect. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect ibuprofen and oxycodone?

• Till using this medication, speak your doctor if you regularly use another medicines that create you sleepy (such as cool or allergy medication, sedatives, another narcotic pain medication, sleeping pills, muscle relaxers, and medication for seizures, depression, or anxiety). They can add to sleepiness caused by oxycodone.

• Also speak your doctor if you are using any of the next drugs:

· a blood thinner such as warfarin (Coumadin, Jantoven);

· a diuretic (water pill);

· an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate);

· aspirin or another NSAIDs such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others;

· heart or blood pressure medicine such as benazepril (Lotensin), enalapril (Vasotec), lisinopril (Prinivil, Zestril), quinapril (Accupril), ramipril (Altace), and others;

· lithium (Eskalith, Lithobid);

· a bronchodilator (such as Atrovent, Spiriva), diuretics (water pills), steroid medicines, or blood thinners;

· methotrexate (Rheumatrex, Trexall);

· an injected narcotic medication such as pentazocine (Talwin), butorphanol (Stadol), or nalbuphine Nubain);

· atropine (Donnatal), dimenhydrinate (Dramamine), or scopolamine (Transderm-Scop); or

· bowel or bladder medications such as dicyclomine (Bentyl), hyoscyamine (Anaspaz, Cystospaz, Levsin), tolterodine (Detrol) and others;

• This list is not complete and another drugs may interact with ibuprofen and oxycodone. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about ibuprofen and oxycodone.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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