CHLORPHENIRAMINE, IBUPROFEN, AND PSEUDOEPHEDRINE

(KLOR fen EER a meen, EYE bue pro fen, SOO doe ee FED rin) Brand: Advil Allergy Sinus, Advil Childrens Allergy Sinus, Advil Multi-Symptom Cold

What is the most significant information I must know about chlorpheniramine, ibuprofen, and pseudoephedrine?

• Do not give this medicine to a baby younger than 12 years old. Always ask a doctor till giving a cough or cool medication to a child. Death can occur from the misuse of cough and cool medicines in very young children.

• Ibuprofen can magnify your risk of life-threatening heart or circulation problems, including heart onslaught or stroke. Do not use this medication just till or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

• Search abnormal medical help if you have symptoms of heart or circulation problems, such as chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.

• Ibuprofen can also magnify your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning at any time while you are taking ibuprofen. Ibuprofen may be more likely to reason stomach bleeding in adults who are 60 or older.

• Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes worsening stomach pain, black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

• You must not use this medicine if you are allergic to ibuprofen or pseudoephedrine, or if you have a stomach ulcer or active bleeding in your stomach or intestines, polyps in your nose, or a history of allergic reaction to aspirin or another NSAIDs.

What is chlorpheniramine, ibuprofen, and pseudoephedrine?

• Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can manufacture symptoms of sneezing, itching, watery eyes, and runny nose.

• Ibuprofen is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Ibuprofen works by reducing hormones that reason inflammation and pain in the body.

• Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can reason nasal congestion (stuffy nose).

• The combination of chlorpheniramine, ibuprofen, and pseudoephedrine is used to treat sneezing, itching, watery eyes, runny nose, stuffy nose, sinus congestion, headache, and pain or fever caused by allergies or the general cold.

• Chlorpheniramine, ibuprofen, and pseudoephedrine may also be used for another purposes not listed in this medicine guide.

What must I discuss with my doctor till taking chlorpheniramine, ibuprofen, and pseudoephedrine?

• Do not use chlorpheniramine, ibuprofen, and pseudoephedrine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take chlorpheniramine, ibuprofen, and pseudoephedrine till the MAO inhibitor has cleared from your body.

• Do not use this medicine if you are allergic to ibuprofen or pseudoephedrine, or if you have:

· a stomach ulcer or active bleeding in your stomach or intestines;

· polyps in your nose; or

· a history of allergic reaction to aspirin or another NSAIDs.

• If you have determined conditions, you may need a doze adjustment or particular trials to safely use this medicine. Till you take this medicine, speak your doctor if you have:

· asthma, emphysema, bronchitis, or if you smoke;

· a history of stomach problems, including heartburn, indigestion, stomach pain, and ulcers or bleeding;

· heart malady, congestive heart failure, tall blood pressure;

· systemic lupus erythematosus (SLE);

· liver or kidney disease;

· a thyroid disorder;

· a bleeding or blood clotting disorder;

· glaucoma;

· diabetes;

· enlarged prostate or problems with urination; or

· if you smoke.

• Taking an NSAID can magnify your risk of life-threatening heart or circulation problems, including heart onslaught or stroke. This risk will magnify the longer you use an NSAID. Do not use this medication just till or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

• NSAIDs can also magnify your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking an NSAID. Older adults may have an even greater risk of these serious gastrointestinal side effects.

• This medicine may be deleterious to an unborn child. Taking ibuprofen during the recent 3 months of pregnancy may result in birth defects and prolonged labor and delivery. Do not take chlorpheniramine, ibuprofen, and pseudoephedrine during the recent 3 months of pregnancy unless your doctor has told you to.

• Chlorpheniramine, ibuprofen, and pseudoephedrine passes into breast milk and may harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

• Ibuprofen may be more likely to reason stomach bleeding in adults who are 60 or older.

How must I take chlorpheniramine, ibuprofen, and pseudoephedrine?

• Use this medicine exactly as directed on the label, or as it has been predesigned by your doctor. Do not use the medicine in larger amounts, or use it for longer than recommended. Cool medication is generally taken only for a short time before your symptoms clear up.

• Take this medication with food or milk if it upsets your stomach.

• Do not take more of this medicine than is recommended. An overdose of ibuprofen can reason hurt to your stomach or intestines. The maximum amount of ibuprofen for adults is 800 milligrams for doze or 3200 mg for day (4 maximum doses). Use only the smallest amount of chlorpheniramine, ibuprofen, and pseudoephedrine needed to get relief from your cool or allergy symptoms.

• Shake the oral suspension (liquid) well just till you measure a doze. To be certain you get the correct doze, measure the liquid with a marked measuring spoon or medication cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

• Call your doctor if you have any new symptoms, or if you have a fever lasting longer than 3 days, stuffy nose lasting longer than 7 days, or pain lasting longer than 10 days. Do not take this medicine for longer than 10 days without your doctor's advice.

• If you need to have any type of surgery, speak the surgeon onward of time if you have taken a cool medication within the past little days.

• This medicine can reason you to have unusual results with allergy skin trials. Speak any doctor who treats you that you are taking an antihistamine.

• Store this medicine at room temperature away from moisture and heat.

What happens if I miss a dose?

• Since cool medication is generally taken only as needed, you may not be on a dosing schedule. If you are taking the medicine regularly, take the missed doze as soon as you remember. If it is nearly time for your following doze, skip the missed doze and take the medication at your following regularly scheduled time. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention if you think you have used too many of this medication. Overdose may reason nausea, vomiting, stomach pain, dizziness, feeling restless or nervous, blurred vision, sweating, breathing problems, or seizure (convulsions).

What must I avoid while taking chlorpheniramine, ibuprofen, and pseudoephedrine?

• This medicine can reason side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

• Avoid drinking alcohol while taking this medicine. If you drink more than 3 alcoholic beverages a day, ibuprofen may magnify your risk of stomach bleeding.

• Avoid becoming overheated or dehydrated during exercice and in hot weather.

• Avoid taking this medicine with diet pills, caffeine pills, or another stimulants (such as ADHD medications) without your doctor's advice. Taking a stimulant together with a decongestant can magnify your risk of unpleasant side effects.

• Do not use any another over-the-counter cough, cool, or pain medicine without first asking your doctor or pharmacist. Chlorpheniramine, ibuprofen, and pseudoephedrine are contained in much medicines accessible over the counter. If you take determined commodity together you may accidentally take too many of either medicine. Read the label of any another medication you are using to see if it contains an antihistamine, decongestant, or pain reliever.

What are the possible side effects of chlorpheniramine, ibuprofen, and pseudoephedrine?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives or blistering skin rash; wheezing or trouble breathing; faint; or swelling of your person, lips, tongue, or throat.

• Stop taking this medicine search medical attention or call your doctor at once if you have a serious side effect such as:

· chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;

· worsening stomach pain, black, bloody, or tarry stools, coughing up blood or vomit that looks like coffee grounds;

· quick, pounding, or uneven heartbeat;

· redness or swelling;

· severe dizziness, trouble sleeping, or nervousness;

· light bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms;

· dangerously tall blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure);

· urinating smaller than normal or not at all;

· skin rash, bruising, severe tingling, numbness, pain, muscle weakness; or

· fever, headache, neck stiffness, chills, heighten sensitivity to easy, purple spots on the skin, and/or seizure (convulsions).

• Smaller serious side effects may include:

· upset stomach, nausea, heartburn, diarrhea, constipation;

· bloating, gas, loss of appetite;

· warmth, tingling, or redness under your skin;

· dizziness, headache, feeling excited or restless;

· skin itching or rash; or

· ringing in your ears.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect chlorpheniramine, ibuprofen, and pseudoephedrine?

• Till taking this medicine, speak your doctor if you regularly use another medicines that create you sleepy (such as another cool or allergy medication, sedatives, narcotic pain medication, sleeping pills, muscle relaxers, and medication for seizures, depression, or anxiety). They can add to sleepiness caused by chlorpheniramine.

• Speak your doctor about all another medications you use, especially:

· a blood thinner such as warfarin (Coumadin);

· steroids (prednisone and others);

· a diuretic (water pill), or medication to treat tall blood pressure;

· aspirin to prevent stroke or heart onslaught (ibuprofen can create aspirin smaller effective in protecting your heart and blood vessels);

· a beta-blocker such as atenolol (Tenormin), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others;

· antidepressants such as amitriptyline (Elavil), doxepin (Sinequan), nortriptyline (Pamelor), and others; or

· another NSAIDs (non-steroidal anti-inflammatory drugs) such as diclofenac (Voltaren), etodolac (Lodine), indomethacin (Indocin), meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Naprosyn), piroxicam (Feldene), and others.

• This list is not complete and there may be another drugs that can interact with chlorpheniramine, ibuprofen, and pseudoephedrine. Speak your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal commodity, and drugs predesigned by another doctors. Do not start using a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about chlorpheniramine, ibuprofen, and pseudoephedrine.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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