(RE goe RAF e nib) Brand: Stivarga
• You must not use regorafenib if past use has caused severe bleeding, or if you have severe liver disease.
• Regorafenib can harm your liver. Stop taking this medication and call your doctor at once if you have nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).
• Regorafenib can also reason severe bleeding. Call your doctor if you have blood in your urine or stools, emergency vaginal bleeding, coughing up blood, or any bleeding that will not stop.
• Regorafenib is a cancer medicine that interferes with the growth and spread of cancer cells in the body.
• Regorafenib is used to treat colorectal cancer. It is also used to treat a rare type of tumor that can affect the esophagus, stomach, or intestines.
• Regorafenib is generally given after another cancer medications have been tried without success.
• Regorafenib may also be used for purposes not listed in this medicine guide.
• You must not use regorafenib if past use has caused severe bleeding, or if you have severe liver disease.
• To create certain regorafenib is safety for you, speak your doctor if you have:
· liver disease;
· heart malady, tall blood pressure;
· bleeding or blood clotting mess such as hemophilia;
· a history of last heart onslaught or stroke (including "mini-stroke"); or
· if you have recently had surgery.
• FDA pregnancy category D. Do not use regorafenib if you are pregnant. It could harm the unborn child. Use effective birth control, and speak your doctor if you become pregnant during treatment.
• Use birth control to prevent pregnancy while you are receiving regorafenib, whether you are a man or a woman. Speak your doctor right away if a pregnancy occurs while either parent is taking regorafenib. Hold using birth control for at least 2 weeks after your treatment ends.
• It is not known whether regorafenib passes into breast milk or if it could harm a nursing child. Speak your doctor if you are breast-feeding a baby.
• Follow all directions on your prescription label. Your doctor may occasionally change your doze to create certain you get the excellent results. Do not take this medication in larger or less amounts or for longer than recommended.
• Regorafenib is generally taken daily for 3 weeks followed by 1 week off the medication. Your doctor will determine how much times you must repeat this treatment cycle.
• Regorafenib works excellent if you take it with a low-fat breakfast.
• Do not crush, chew, or interrupt a regorafenib tablet. Swallow it intact.
• While using regorafenib, your blood pressure will need to be checked often. You may also need frequent blood trials at your doctor's office.
• If you need surgery, speak the surgeon onward of time that you are using regorafenib. You may need to stop using the medication at least 2 weeks till your surgery. Follow your doctor's instructions.
• Store at room temperature away from moisture and heat. Hold the tablets in their original container, along with the packet or canister of moisture-absorbing preservative.
• Throw away any regorafenib tablets not used within 28 days after opening the bottle.
• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.
• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.
• Grapefruit and grapefruit juice may interact with regorafenib and lead to potentially dangerous effects. Avoid the use of grapefruit commodity while taking regorafenib.
• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.
• Stop using regorafenib and call your doctor at once if you have:
· fever, chills, flu symptoms, mouth sores, severe or ongoing vomiting or diarrhea;
· feeling very thirsty or hot, being unable to urinate, hard sweating, or hot and dry skin;
· blood in your urine or stools, coughing up blood or vomit that looks like coffee grounds;
· hard menstrual periods or emergency vaginal bleeding;
· any bleeding that will not stop;
· chest pain and severe dizziness, fainting, feeling short of breath;
· headache, confusion, change in mental status, vision loss, seizure (convulsions);
· upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
· dangerously tall blood pressure (blurred vision, buzzing in your ears, anxiety, uneven heartbeats);
· rash, blisters, oozing, or severe pain in the palms of your hands or the soles of your feet;
· any wound that will not heal; or
· severe skin reaction -- fever, sore throat, swelling in your person or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the person or upper body) and causes blistering and peeling.
• General side effects may include:
· diarrhea, stomach pain, weight loss;
· hoarse voice; or
· feeling weak or tired.
• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.
• Much drugs can interact with regorafenib. Not all possible interactions are listed here. Speak your doctor about all your medications and any you start or stop using during treatment with regorafenib, especially:
· bosentan;
· imatinib;
· nefazodone;
· St. John's wort;
· an antibiotic--clarithromycin, nafcillin, rifabutin, rifampin, rifapentine, telithromycin;
· antifungal medication--itraconazole, ketoconazole, posaconazole, voriconazole;
· heart medication--nicardipine, quinidine;
· hepatitis C medications--boceprevir, telaprevir;
· HIV/AIDS medication--atazanavir, delavirdine, efavirenz, fosamprenavir, indinavir, nelfinavir, nevirapine, ritonavir, saquinavir; or
· seizure medication--carbamazepine, fosphenytoin, oxcarbazepine, phenobarbital, phenytoin, primidone.
• This list is not complete and much another drugs can interact with regorafenib. This includes prescription and over-the-counter medicines, vitamins, and herbal commodity. Give a list of all your medicines to any healthcare provider who treats you.
• Your pharmacist can provide more information about regorafenib.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
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