HYDROCHLOROTHIAZIDE AND ALISKIREN

(HYE droe KLOR oh THYE a zide and a LIS ke rin) Brand: Tekturna HCT

What is the most significant information I must know about hydrochlorothiazide and aliskiren?

• You must not use this medicine if you are allergic to aliskiren or hydrochlorothiazide, if you are unable to urinate, or if you are also using itraconazole (Sporanox) or cyclosporine (Gengraf, Neoral, Sandimmune).

• FDA pregnancy category D. Do not use hydrochlorothiazide and aliskiren if you are pregnant. Stop using this medicine and speak your doctor right away if you become pregnant.

• Till you take hydrochlorothiazide and aliskiren, speak your doctor if you have asthma, low or tall levels of potassium in your blood, kidney or liver malady, glaucoma, gout, lupus, diabetes, or an allergy to sulfa drugs or penicillin.

• Do not use potassium supplements or salt substitutes while you are taking hydrochlorothiazide and aliskiren, unless your doctor has told you to.

• It may take up to 4 weeks for this medicine to control your blood pressure. Hold using this medication as directed, even if you feel well. Tall blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.

What is hydrochlorothiazide and aliskiren?

• Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too many salt, which can reason fluid retention.

• Aliskiren is an anti-hypertensive (blood pressure lowering) medicine. It works by decreasing substances in the body that narrow blood vessels and raise blood pressure.

• The combination of hydrochlorothiazide and aliskiren is used to treat tall blood pressure (hypertension).

• Hydrochlorothiazide and aliskiren may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking hydrochlorothiazide and aliskiren?

• You must not use this medicine if:

· you are allergic to aliskiren (Tekturna) or hydrochlorothiazide (Carozide, Diaqua, Ezide HCTZ, HydroDiuril, Microzide, and others);

· you are unable to urinate; or

· you are also using itraconazole (Sporanox) or cyclosporine (Gengraf, Neoral, Sandimmune).

• If you have diabetes or kidney disease, you may not be able to take hydrochlorothiazide and aliskiren if you are also taking any of the next heart or blood pressure medications:

· azilsartan (Edarbi, Edarbyclor), candesartan (Atacand), eprosartan (Teveten), irbesartan (Avapro, Avalide), losartan (Cozaar, Hyzaar), olmesartan (Benicar), valsartan (Diovan), telmisartan (Micardis); or

· benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril.

• To create certain you can safely take hydrochlorothiazide and aliskiren, speak your doctor if you have any of these another conditions:

· asthma;

· low or tall levels of potassium in your blood;

· glaucoma;

· kidney disease;

· liver disease;

· gout;

· systemic lupus erythematosus (SLE);

· diabetes; or

· an allergy to sulfa drugs or penicillin.

• FDA pregnancy category D. Do not use hydrochlorothiazide and aliskiren if you are pregnant. Stop using this medicine and speak your doctor right away if you become pregnant. Hydrochlorothiazide and aliskiren can reason injury or death to the unborn child if you take the medication during your second or third trimester. Use effective birth control while taking hydrochlorothiazide and aliskiren.

• It is not known whether this medicine passes into breast milk or if it could harm a nursing child. You must not breast-feed while you are using hydrochlorothiazide and aliskiren.

• Do not give this medicine to anyone under 18 years old without medical advice.

How must I take hydrochlorothiazide and aliskiren?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.

• Your doctor may occasionally change your doze to create certain you get the excellent results.

• You may take this medicine with or without food, but take it the same way each time.

• Conditions that may reason very low blood pressure include: vomiting, diarrhea, hard sweating, heart malady, dialysis, a low salt diet, or taking diuretics (water pills). Speak your doctor if you have a prolonged diseases that causes diarrhea or vomiting.

• Your blood pressure will need to be checked often. Visit your doctor regularly.

• Tall blood pressure is sometimes treated with a combination of drugs. Use all medications as directed by your doctor. Read the medicine manual or patient instructions provided with every medicine. Do not change your doses or medicine schedule without your doctor's advice.

• If you need surgery or medical trials, speak the doctor onward of time that you are taking medicine that contains hydrochlorothiazide. You may need to stop using the medication for a short time.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose symptoms may include dry mouth, heighten thirst, drowsiness, restless feeling, confusion, nausea, vomiting, heighten urination, muscle pain or weakness, quick heart course, feeling light-headed, fainting, or seizure (convulsions).

What must I avoid while taking hydrochlorothiazide and aliskiren?

• Avoid taking this medicine with a high-fat meal, which can create it harder for your body to absorb hydrochlorothiazide and aliskiren.

• Do not use potassium supplements or salt substitutes while you are taking hydrochlorothiazide and aliskiren, unless your doctor has told you to.

• Avoid getting up too quick from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

• Drinking alcohol can further lower your blood pressure and may magnify determined side effects of hydrochlorothiazide and aliskiren.

• Avoid becoming overheated or dehydrated during exercice and in hot weather. Follow your doctor's instructions about the type and amount of liquids you must drink. In some cases, drinking too many liquid can be as unsafe as not drinking enough.

What are the possible side effects of hydrochlorothiazide and aliskiren?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Stop using hydrochlorothiazide and aliskiren and call your doctor at once if you have a serious side effect such as:

· eye pain, vision problems;

· feeling like you might pass out;

· tall potassium (slow heart course, weak pulse, muscle weakness, tingly feeling);

· low potassium (confusion, uneven heart course, extreme thirst, heighten urination, leg discomfort, muscle weakness or limp feeling);

· urinating smaller than normal, or not at all;

· joint pain or swelling with fever, swollen glands, muscle aches, nausea, vomiting, chest pain, unusual thoughts or behavior, and/or seizure (convulsions); or

· severe skin reaction -- fever, sore throat, swelling in your person or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the person or upper body) and causes blistering and peeling.

• Smaller serious side effects may include:

· dizziness, spinning sensation;

· diarrhea, stomach pain, indigestion;

· weary feeling;

· flu symptoms; or

· dry cough.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect hydrochlorothiazide and aliskiren?

• Speak your doctor about all another medicines you use, especially:

· lithium (Eskalith, Lithobid);

· a blood thinner such as warfarin (Coumadin, Jantoven);

· aspirin or another NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others;

· a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Luminal, Solfoton);

· cholesterol medicine such as atorvastatin (Lipitor), cholestyramine (Prevalite, Questran) or colestipol (Colestid);

· insulin or diabetes medication you take by mouth; or

· steroid medicine such as prednisone (Deltasone, Sterapred), methylprednisolone (Medrol), fluticasone (Advair , Flonase, Flovent, Veramyst), beclomethasone (Qvar), budesonide (Pulmicort, Rhinocort, Symbicort), dexamethasone (Cortastat, Dexasone, Solurex, DexPak), mometasone (Asmanex, Nasonex), triamcinolone (Nasacort), and others.

• This list is not complete and another drugs may interact with hydrochlorothiazide and aliskiren. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about hydrochlorothiazide and aliskiren.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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