DEXTROMETHORPHAN AND DOXYLAMINE

(DEX troe me THOR fan an dox IL a meen) Brand: NyQuil Cough, Safetussin PM

What is the most significant information I must know about dextromethorphan and doxylamine?

• You must not use this medication if you have severe constipation, a blockage in your stomach or intestines, or if you are unable to urinate.

• Do not use this medication if you have untreated or uncontrolled illness such as glaucoma, asthma or COPD, heart malady, or a thyroid disorder.

• Do not use this medication if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the recent 14 days. A dangerous drug interaction could occur, leading to serious side effects.

What is dextromethorphan and doxylamine?

• Dextromethorphan is a cough suppressant. It affects the signals in the brain that trigger cough reflex.

• Doxylamine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can manufacture symptoms of sneezing, itching, watery eyes, and runny nose.

• The combination of dextromethorphan and doxylamine is used to treat cough, runny or stuffy nose, sneezing, itching, and watery eyes caused by allergies, the general cool, or the flu.

• Dextromethorphan and doxylamine will not treat a cough that is caused by smoking, asthma, or emphysema.

• Dextromethorphan and doxylamine may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking dextromethorphan and doxylamine?

• You must not use this medication if you have severe constipation, a blockage in your stomach or intestines, or if you are unable to urinate.

• Do not use this medication if you have untreated or uncontrolled illness such as glaucoma, asthma or COPD, tall blood pressure, heart malady, coronary artery malady, or overactive thyroid.

• Ask a doctor or pharmacist if it is safety for you to take this medication if you have:

· a blockage in your digestive tract (stomach or intestines);

· liver or kidney disease;

· cough with mucus, or cough caused by emphysema or chronic bronchitis;

· enlarged prostate or urination problems; or

· if you take potassium (Cytra, Epiklor, K-Lyte, K-Phos, Kaon, Klor-Con, Polycitra, Urocit-K).

• FDA pregnancy category C. It is not known whether dextromethorphan and doxylamine will harm an unborn child. Do not use this medication without a doctor's advice if you are pregnant.

• Dextromethorphan and doxylamine may pass into breast milk and may harm a nursing child. Antihistamines may also slow breast milk manufacture. Do not use this medication without a doctor's advice if you are breast-feeding a baby.

• Artificially sweetened cough or cool medication may contain phenylalanine. If you have phenylketonuria (PKU), check the medicine label to see if the product contains phenylalanine.

How must I take dextromethorphan and doxylamine?

• Use exactly as directed on the label, or as predesigned by your doctor. Do not use in larger or less amounts or for longer than recommended. This medication is generally taken only for a short time before your symptoms clear up.

• Do not take for longer than 7 days in a row. Conversation with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache or skin rash.

• Do not give this medicine to a baby younger than 4 years old. Always ask a doctor till giving a cough or cool medication to a child. Death can occur from the misuse of cough and cool medicines in very young children.

• Measure liquid medication with a particular dose-measuring spoon or medication cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

• If you need surgery or medical trials, speak the surgeon or doctor onward of time if you have taken this medication within the past little days.

• Store at room temperature away from moisture and heat. Do not let the liquid to freeze.

What happens if I miss a dose?

• Since this medication is taken when needed, you may not be on a dosing schedule. If you are taking the medicine regularly, take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose symptoms may also include severe forms of some of the side effects listed in this medicine guide.

What must I avoid while taking dextromethorphan and doxylamine?

• Drinking alcohol can magnify determined side effects of dextromethorphan and doxylamine.

• Ask a doctor or pharmacist till using any another cool, cough, allergy, or sleep medication. Antihistamines and cough suppressants are contained in much combination medicines. Taking determined commodity together can reason you to get too many of a determined drug. Check the label to see if a medication contains an antihistamine or cough suppressant.

• This medication may reason blurred vision or impair your thinking or reactions. Avoid driving or operating machinery before you know how dextromethorphan and doxylamine will affect you.

• Avoid becoming overheated or dehydrated during exercice and in hot weather. Doxylamine can decrease sweating and you may be more prone to heat stroke.

What are the possible side effects of dextromethorphan and doxylamine?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• Stop using dextromethorphan and doxylamine and call your doctor at once if you have a serious side effect such as:

· quick, slow, or uneven heart rate;

· severe dizziness or anxiety, feeling like you might pass out;

· severe headache;

· mood changes;

· urinating smaller than normal or not at all;

· tremor, seizure (convulsions);

· light bruising or bleeding, unusual weakness; or

· fever.

• Smaller serious side effects may include:

· dizziness, drowsiness;

· dry mouth, nose, or throat;

· diarrhea, constipation;

· blurred vision;

· sleep problems (insomnia); or

· feeling nervous, restless, or irritable;.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect dextromethorphan and doxylamine?

• Ask a doctor or pharmacist till using this medication if you regularly use another medicines that create you sleepy (such as narcotic pain medicine, sedatives, sleeping pills, muscle relaxers, and medication for seizures, depression or anxiety). They can add to sleepiness caused by doxylamine.

• Ask a doctor or pharmacist if it is safety for you to take dextromethorphan and doxylamine if you are also using any of the next drugs:

· atropine (Atreza, Sal-Tropine);

· benztropine (Cogentin);

· topiramate (Topamax);

· tramadol (Ultram, Ultracet);

· zonisamide (Zonegran);

· an antidepressant such as amitriptyline (Elavil, Vanatrip, Limbitrol), doxepin (Sinequan, Silenor), nortriptyline (Pamelor), and others;

· anti-nausea medications such as belladonna (Donnatal), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm Scop);

· bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), solifenacin (Vesicare), tolterodine (Detrol), or Urogesic Blue;

· bronchodilators such as ipratropium (Atrovent) or tiotropium (Spiriva);

· irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Hyomax), or propantheline (Pro Banthine); or

· ulcer medication such as glycopyrrolate (Robinul) or mepenzolate (Cantil).

• There may be another drugs that can interact with dextromethorphan and doxylamine. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about dextromethorphan and doxylamine.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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