CHLORPHENIRAMINE, GUAIFENESIN, HYDROCODONE, AND PSEUDOEPHEDRINE

(KLOR fen IR a meen, gwye FEN e sin, HYE droe KOE done, SOO doe ee FED rin) Brand: Z-Tuss 2

What is the most significant information I must know about chlorpheniramine, guaifenesin, hydrocodone, and pseudoephedrine?

• Do not use this medicine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take a cough and cool medication till the MAO inhibitor has cleared from your body.

• Hydrocodone may be habit-forming and must be used only by the face it was predesigned for. Never share this medicine with other face, especially somebody with a history of drug abuse or addiction. Hold the medicine in a seat where others can't get to it.

• Do not give this medicine to a baby younger than 6 years old. Always ask a doctor till giving a cough or cool medication to a child. Death can occur from the misuse of cough and cool medicines in very young children.

• Ask a doctor or pharmacist till using any another cough, cool, allergy, or sleep medication. Chlorpheniramine, guaifenesin, and pseudoephedrine are contained in much combination medicines. Taking determined commodity together can reason you to get too many of a determined drug. Check the label to see if a medication contains an antihistamine, decongestant, or expectorant.

What is chlorpheniramine, guaifenesin, hydrocodone, and pseudoephedrine?

• Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can manufacture symptoms of sneezing, itching, watery eyes, and runny nose.

• Guaifenesin is an expectorant. It helps loosen mucus congestion in your chest and throat, making it easier to cough out through your mouth.

• Hydrocodone is a narcotic cough suppressant similar to codeine. Hydrocodone affects the signals in the brain that trigger cough reflex.

• Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can reason nasal congestion (stuffy nose).

• The combination of chlorpheniramine, guaifenesin, hydrocodone, and pseudoephedrine is used to treat sinus congestion, runny nose, sneezing, itching, watery eyes, cough, and chest congestion caused by allergies, upper respiratory infections, or the general cold.

• This medicine will not treat a cough that is caused by smoking, asthma, or emphysema.

• Chlorpheniramine, guaifenesin, hydrocodone, and pseudoephedrine may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking chlorpheniramine, guaifenesin, hydrocodone, and pseudoephedrine?

• Do not use a cough or cool medication if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take cough or cool medication till the MAO inhibitor has cleared from your body.

• To create certain you can safely take this medicine, speak your doctor if you have any of these another conditions:

· heart malady or tall blood pressure;

· asthma, COPD, sleep apnea, or another breathing disorders;

· diabetes;

· glaucoma;

· a thyroid disorder;

· epilepsy or another seizure disorder;

· kidney or liver disease;

· enlarged prostate or urination problems;

· a stomach or intestinal disorder;

· a history of head injury or brain tumor;

· Addison's malady or another adrenal gland disorders; or

· a history of drug or alcohol addiction.

• FDA pregnancy category C. It is not known whether this medicine will harm an unborn child. Hydrocodone may reason addiction or withdrawal symptoms in a newborn if the mother takes the medicine during pregnancy. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.

• This medicine may pass into breast milk and could harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

• Older adults may be more likely to have side effects from this medication.

How must I take chlorpheniramine, guaifenesin, hydrocodone, and pseudoephedrine?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label. Cough or cool medication is generally taken for only a short time before your symptoms clear up.

• Take this medicine with food or milk if it upsets your stomach.

• Measure liquid medication with a particular dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

• Drink plenty of water or another fluids to help loosen congestion and prevent dry mouth or throat.

• Conversation with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

• If you need surgery, speak the surgeon onward of time if you have taken a cool medication within the past little days.

• This medicine can reason you to have unusual results with allergy skin trials. Speak any doctor who treats you that you are taking an antihistamine.

• Store at room temperature, away from heat, easy, and moisture.

• Hold track of the amount of medication used from every new bottle. Hydrocodone is a drug of abuse and you must be aware if anyone is using your medication improperly or without a prescription.

What happens if I miss a dose?

• Since cough or cool medication is generally taken only as needed, you may not be on a dosing schedule. If you are taking the medicine regularly, take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222. An overdose of hydrocodone can be fatal.

• Overdose symptoms may include quick or uneven heart course, extreme drowsiness, feeling restless or hyperactive, confusion, hallucinations, warmth or redness in your person, cool or clammy skin, blue-colored lips or fingernails, weak or shallow breathing, fainting, or seizure (convulsions).

What must I avoid while taking chlorpheniramine, guaifenesin, hydrocodone, and pseudoephedrine?

• This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

• Drinking alcohol can magnify determined side effects of chlorpheniramine, guaifenesin, or hydrocodone.

What are the possible side effects of chlorpheniramine, guaifenesin, hydrocodone, and pseudoephedrine?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Stop taking this medicine and call your doctor at once if you have a serious side effect such as:

· severe dizziness, fainting, anxiety, restless feeling, nervousness, or tremor;

· quick, pounding, or uneven heartbeats;

· slow heartbeat, weak pulse, shallow breathing;

· confusion, hallucinations, unusual thoughts or behavior;

· ringing in your ears;

· painful or difficult urination;

· pale skin, light bruising or bleeding, unusual weakness; or

· heighten blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure).

• Smaller serious side effects may include:

· dizziness, drowsiness, headache;

· blurred vision;

· dry mouth, nose, or throat;

· nausea, stomach pain, constipation; or

· restless or excitability (especially in children).

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect chlorpheniramine, guaifenesin, hydrocodone, and pseudoephedrine?

• Till taking this medicine, speak your doctor if you regularly use another medicines that create you sleepy (such as narcotic pain medication, sleeping pills, muscle relaxers, and medication for seizures, depression, or anxiety). They can add to sleepiness caused by chlorpheniramine, guaifenesin, or hydrocodone.

• Speak your doctor about all another medicines you use, especially:

· sibutramine (Meridia);

· memantine (Namenda);

· methyldopa (Aldomet);

· reserpine;

· an antidepressant such as amitriptyline (Elavil), clomipramine (Anafranil), imipramine (Janimine, Tofranil), and others; or

· a beta-blocker such as atenolol (Tenormin), carteolol (Cartrol), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal), sotalol (Betapace), timolol (Blocadren), and others.

• This list is not complete and another drugs may interact with chlorpheniramine, guaifenesin, hydrocodone, and pseudoephedrine. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about chlorpheniramine, guaifenesin, hydrocodone, and pseudoephedrine.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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