CHLORCYCLIZINE, CODEINE, AND PHENYLEPHRINE

(klor SYE kli zeen KOE deen and FEN il EFF rin) Brand: Nasotuss

What is the most significant information I must know about chlorcyclizine, codeine, and phenylephrine?

• You must not use this medicine if you have severe liver malady, severe constipation, severe colitis or toxic megacolon, if you are unable to urinate, if you have been sick with diarrhea, if you recently drank big amounts of alcohol, or if you have a head injury or brain tumor.

• Do not use cough and cool medication if you have untreated or uncontrolled illness such as glaucoma, asthma or COPD, tall blood pressure, heart malady, or overactive thyroid.

• Do not use a cough or cool medication if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the recent 14 days. A dangerous drug interaction could occur, leading to serious side effects.

What is chlorcyclizine, codeine, and phenylephrine?

• Chlorcyclizine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can manufacture symptoms of sneezing, itching, watery eyes, and runny nose.

Codeine is a narcotic cough suppressant. It affects the signals in the brain that trigger cough reflex.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can reason nasal congestion (stuffy nose).

• The combination of chlorcyclizine, codeine, and phenylephrine is used to treat runny or stuffy nose, sneezing, itching, watery eyes, cough, and sinus congestion caused by allergies, the general cool, or the flu.

Chlorcyclizine, codeine, and phenylephrine may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking chlorcyclizine, codeine, and phenylephrine?

• Do not use a cough or cool medication if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the recent 14 days. A dangerous drug interaction could occur, leading to serious side effects.

• You must not use this medicine if you have severe liver malady, severe constipation, severe colitis or toxic megacolon, if you are unable to urinate, if you have been sick with diarrhea, if you recently drank big amounts of alcohol, or if you have a head injury or brain tumor.

• Do not use cough and cool medication if you have untreated or uncontrolled illness such as glaucoma, asthma or COPD, tall blood pressure, heart malady, or overactive thyroid.

• To create certain you can safely take this medication, speak your doctor if you have any of these another conditions:

· a blockage in your digestive tract (stomach or intestines), a colostomy or ileostomy;

· diabetes;

· liver or kidney disease;

· epilepsy or another seizure disorder;

· cough with mucus, or cough caused by smoking, emphysema, or chronic bronchitis;

· enlarged prostate or urination problems;

· an adrenal gland tumor or mess (such as Addison's disease); or

· if you take potassium (Cytra, Epiklor, K-Lyte, K-Phos, Kaon, Klor-Con, Polycitra, Urocit-K).

Codeine may be habit forming and must be used only by the face it was predesigned for. Never share this medication with other face, especially somebody with a history of drug abuse or addiction.

• FDA pregnancy category C. Codeine may reason addiction or withdrawal symptoms in a newborn if the mother takes the medicine during pregnancy. Speak your doctor if you are pregnant or plan to become pregnant while using this medicine.

Codeine can pass into breast milk and may harm a nursing child. The use of codeine by some nursing mothers may lead to life-threatening side effects in the child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

How must I take chlorcyclizine, codeine, and phenylephrine?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label. Cough or cool medication is generally taken only for a short time before your symptoms clear up.

• Do not take for longer than 7 days in a row. Conversation with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache or skin rash.

• Do not give this medicine to a baby younger than 6 years old without medical advice. Always ask a doctor till giving a cough or cool medication to a child. Death can occur from the misuse of cough and cool medicines in very young children.

• If you need surgery or medical trials, speak the surgeon or doctor onward of time if you have taken a cough or cool medication within the past little days.

• Store at room temperature away from moisture and heat. Do not freeze. Hold track of the amount of medication used from every new bottle. Codeine is a drug of abuse and you must be aware if anyone is using your medication improperly or without a prescription.

What happens if I miss a dose?

• Since cough or cool medication is taken when needed, you may not be on a dosing schedule. If you are taking the medicine regularly, take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222. An overdose of codeine can be fatal.

• Overdose symptoms may include confusion, extreme weakness, pinpoint pupils, cool and clammy skin, weak pulse, slow breathing, fainting, or breathing that stops. Overdose symptoms may also include severe forms of some of the side effects listed in this medicine guide.

What must I avoid while taking chlorcyclizine, codeine, and phenylephrine?

Do not drink alcohol while you are taking medication that contains codeine. Dangerous side effects or death can occur when alcohol is combined with a narcotic medication. Check your food and medication labels to be certain these commodity do not contain alcohol.

• Ask a doctor or pharmacist till using any another cool, cough, allergy, or sleep medication. Antihistamines, decongestants, and cough suppressants are contained in much combination medicines. Taking determined commodity together can reason you to get too many of a determined drug. Check the label to see if a medication contains an antihistamine, decongestant, or cough suppressant.

• This medication may reason blurred vision or impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

What are the possible side effects of chlorcyclizine, codeine, and phenylephrine?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Stop taking the medicine and call your doctor at once if you have a serious side effect such as:

· quick or pounding heartbeats;

· confusion, hallucinations, unusual thoughts or behavior;

· severe dizziness, anxiety, restless feeling, or nervousness;

· urinating smaller than normal or not at all;

· light bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms; or

· dangerously tall blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, chest pain, shortness of breath, uneven heartbeats, seizure).

• Smaller serious side effects may include:

· dizziness, drowsiness, problems with memory or concentration;

· dry mouth, nose, or throat, heighten sweating or urination;

· mild stomach pain, diarrhea or constipation;

· sleep problems (insomnia);

· blurred vision; or

· flushing (warmth, redness, or tingly feeling).

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect chlorcyclizine, codeine, and phenylephrine?

• Till using this medication, speak your doctor if you regularly use another medicines that create you sleepy (such as another cool or allergy medicines, sedatives, narcotic pain medication, sleeping pills, muscle relaxers, and medication for seizures, depression, or anxiety). They can add to sleepiness caused by chlorcyclizine or codeine.

• Speak your doctor about all another medications you use, especially:

· naloxone (Narcan, Suboxone);

· topiramate (Topamax);

· tramadol (Ultram, Ultracet);

· zonisamide (Zonegran);

· a diuretic (water pill);

· an antidepressant such as amitriptyline (Elavil, Vanatrip, Limbitrol), bupropion (Wellbutrin), doxepin (Sinequan, Silenor), nortriptyline (Pamelor), and others;

· anti-nausea medications such as belladonna (Donnatal), dimenhydrinate (Dramamine), droperidol (Inapsine), methscopolamine (Pamine), or scopolamine (Transderm Scop);

· bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), solifenacin (Vesicare), tolterodine (Detrol), or Urogesic Blue;

· bowel cleansing preparations (Half Lytely, Fleet Prep Kit, Evac-Q-Kwik, GoLytely, Supraprep, and others);

· bronchodilators such as ipratropium (Atrovent) or tiotropium (Spiriva);

· irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Hyomax), or propantheline (Pro Banthine); or

· ulcer medication such as glycopyrrolate (Robinul) or mepenzolate (Cantil).

• This list is not complete and another drugs may interact with chlorcyclizine, codeine, and phenylephrine. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about chlorcyclizine, codeine, and phenylephrine.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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