ALISKIREN AND VALSARTAN

(a LIS ke rin and val SAR tan) Brand: Valturna

What is the most significant information I must know about aliskiren and valsartan?

• Do not use this medicine if you are pregnant. Stop using this medicine and speak your doctor right away if you become pregnant.

• Till you take aliskiren and valsartan, speak your doctor if you have kidney or liver malady, tall levels of potassium in your blood (hyperkalemia), heart malady or last heart onslaught, congestive heart failure, or if you are on a low-salt diet.

• If you take aliskiren and valsartan with meals, avoid high-fat foods. They can create it harder for your body to absorb aliskiren and valsartan.

• Conditions that may reason very low blood pressure include: vomiting, diarrhea, hard sweating, heart malady, dialysis, a low-salt diet, or taking diuretics (water pills). Follow your doctor's instructions about the type and amount of liquids you must drink while taking aliskiren and valsartan. Speak your doctor if you have a prolonged diseases that causes diarrhea or vomiting.

What is aliskiren and valsartan?

• Aliskiren is an anti-hypertensive (blood pressure lowering) medicine. It works by decreasing substances in the body that narrow blood vessels and raise blood pressure.

• Valsartan is in a group of drugs called angiotensin II receptor antagonists. Valsartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.

• The combination of aliskiren and valsartan is used to treat tall blood pressure (hypertension).

• Aliskiren and valsartan may also be used for purposes not listed in this medicine guide.

What must I discuss with my health care provider till taking aliskiren and valsartan?

• You must not use this medicine if you are allergic to aliskiren (Tekturna) or valsartan (Diovan), or if you are also using cyclosporine (Gengraf, Neoral, Sandimmune) or itraconazole (Sporanox).

• If you have diabetes or kidney disease, you may not be able to take aliskiren and valsartan if you are also taking any of the next heart or blood pressure medications:

· azilsartan (Edarbi, Edarbyclor), candesartan (Atacand), eprosartan (Teveten), irbesartan (Avapro, Avalide), losartan (Cozaar, Hyzaar), olmesartan (Benicar), valsartan (Diovan), telmisartan (Micardis); or

· benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik, Tarka).

• To create certain you can safely take aliskiren and valsartan, speak your doctor if you have any of these another conditions:

· kidney malady (or if you are on dialysis);

· liver disease;

· tall levels of potassium in your blood (hyperkalemia);

· congestive heart failure;

· heart malady or last heart onslaught; or

· if you are on a low-salt diet.

• FDA pregnancy category D. Do not use aliskiren and valsartan if you are pregnant. Stop using this medicine and speak your doctor right away if you become pregnant. Aliskiren and valsartan can reason injury or death to the unborn child if you take the medication during your second or third trimester. Use effective birth control while taking this medication.

• It is not known whether aliskiren and valsartan passes into breast milk or if it could harm a nursing child. You must not use this medicine while you are breast-feeding a baby.

How must I take aliskiren and valsartan?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.

• Your doctor may occasionally change your doze to create certain you get the excellent results.

• Take aliskiren and valsartan with a full glass of water.

• You may take aliskiren and valsartan with or without food, but take it the same way each time.

• If you take aliskiren and valsartan with meals, avoid high-fat foods. They can create it harder for your body to absorb aliskiren and valsartan.

• It may take up to 2 weeks of using this medication till your blood pressure improves. Hold using this medication as directed, even if you feel well. Tall blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose symptoms may include quick or slow heart course, feeling light-headed, or fainting.

What must I avoid while taking aliskiren and valsartan?

• Drinking alcohol can further lower your blood pressure and may magnify determined side effects of aliskiren and valsartan.

• Avoid getting up too quick from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

• Do not use salt substitutes or potassium supplements while taking aliskiren and valsartan, unless your doctor has told you to.

What are the possible side effects of aliskiren and valsartan?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Call your doctor at once if you have any of these serious side effects:

· feeling like you might pass out; or

· slow heart course, weak pulse, muscle weakness, tingly feeling.

• Smaller serious side effects may be more likely to occur, such as:

· weary feeling;

· stuffy nose, sore throat, cough;

· stomach pain or upset, diarrhea, heartburn;

· numbness or tingly feeling; or

· muscle cramps.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect aliskiren and valsartan?

• Speak your doctor about all another medications you use, especially another blood pressure medications, or:

· atorvastatin (Lipitor);

· a diuretic (water pill) such as furosemide (Lasix);

· an antibiotic such as ketoconazole (Nizoral) or rifampin (Rifater, Rifadin, Rifamate);

· a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others;

· a potassium supplement such as K-Dur, Klor-Con; or

· salt substitutes that contain potassium.

• This list is not complete and another drugs may interact with aliskiren and valsartan. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about aliskiren and valsartan.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

(36)