(A doe tras TOOZ ue mab em TAN seen) Brand: Kadcyla
• Do not use ado-trastuzumab emtansine if you are pregnant. It could harm the unborn child. Use effective birth control, and speak your doctor if you become pregnant during treatment.
• Ado-trastuzumab emtansine can harm your liver. Call your doctor at once if you have upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).
• Till you receive every ado-trastuzumab emtansine injection, your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG).
• Ado-trastuzumab emtansine is a cancer medicine that interferes with the growth and spread of cancer cells in the body.
• Ado-trastuzumab emtansine is used to treat a determined type of breast cancer that has spread to another parts of the body.
• Ado-trastuzumab emtansine is generally given after another cancer medications have been tried without success.
• Ado-trastuzumab emtansine may also be used for purposes not listed in this medicine guide.
• You must not use ado-trastuzumab emtansine if you are allergic to it, or if you are pregnant.
• To create certain ado-trastuzumab emtansine is safety for you, speak your doctor if you have:
· bleeding or blood clotting mess such as hemophilia; or
· asthma, chronic obstructive pulmonary malady (COPD), sleep apnea, or another breathing disorder.
• FDA pregnancy category D. Do not use ado-trastuzumab emtansine if you are pregnant. It could harm the unborn child. Speak your doctor if you become pregnant during treatment. Use effective birth control while you are using this medicine and for at least 6 months after your treatment ends.
• You may need to have a negative pregnancy test till starting this treatment.
• It is not known whether ado-trastuzumab emtansine passes into breast milk or if it could harm a nursing child. You must not breast-feed while using this medicine.
• Till you receive this medication, your doctor will perform blood trials to create certain ado-trastuzumab emtansine is the right medicine to treat your cancer.
• Ado-trastuzumab emtansine is injected into a vein through an IV. A healthcare provider will give you this injection.
• Speak your caregivers if you feel any burning, pain, or swelling near the IV needle when ado-trastuzumab emtansine is injected.
• Ado-trastuzumab emtansine is generally given once each 3 weeks before your body no longer responds to the medicine. Your doctor will determine how long to treat you with ado-trastuzumab emtansine.
• You may need frequent medical trials at your doctor's office to be certain this medicine is not causing deleterious effects. Your cancer treatments may be delayed based on the results of these tests.
• Call your doctor for instructions if you miss an appointment for your ado-trastuzumab emtansine injection.
• Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
• Avoid activities that may magnify your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.
• This medication can pass into body fluids (including urine, feces, vomit, semen, vaginal fluid). For at least 48 hours after you receive a doze, avoid allowing your body fluids to come into contact with your hands or another surfaces. Patients and caregivers must wear rubber gloves while cleaning up body fluids, handling contaminated trash or laundry or changing diapers. Wash hands till and after removing gloves. Wash soiled clothing and linens apart from another laundry.
• Body fluids must not be handled by a woman who is pregnant or who may become pregnant. Use condoms during sexual activity to avoid exposure to body fluids.
• Some side effects may occur during the injection. Speak your caregiver right away if you feel cool, light-headed, feverish or sweaty, or have chest tightness, rapid heartbeats, or trouble breathing.
• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.
• Call your doctor at once if you have:
· nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
· chest pain, dry cough, fever, wheezing, feeling short of breath;
· shortness of breath (even with mild exertion), swelling, rapid weight gain;
· pounding heartbeats or fluttering in your chest;
· light bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
· numbness or tingling in your hands or feet;
· fever, unusual weakness; or
· blisters or ulcers in your mouth, red or swollen gums, trouble swallowing.
• General side effects may include:
· constipation, diarrhea;
· stomach pain, vomiting, dry mouth;
· joint or muscle pain;
· weary feeling; or
· headache.
• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.
• Speak your doctor about all medicines you use, and those you start or stop using during your treatment with ado-trastuzumab emtansine, especially:
· imatinib;
· isoniazid;
· nefazodone;
· an antibiotic--clarithromycin, telithromycin;
· antifungal medication--itraconazole, ketoconazole, posaconazole, voriconazole;
· heart medication--nicardipine, quinidine;
· hepatitis C medications--boceprevir, telaprevir; or
· HIV/AIDS medication--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir.
• This list is not complete. Another drugs may interact with ado-trastuzumab emtansine, including prescription and over-the-counter medicines, vitamins, and herbal commodity. Not all possible interactions are listed in this medicine manual.
• Your doctor or pharmacist can provide more information about ado-trastuzumab emtansine.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.