KETOROLAC

(KEE toe ROLE ak) Brand: Toradol, Toradol IM, Toradol IV/IM

What is the most significant information I must know about ketorolac?

• This medication can magnify your risk of life-threatening heart or circulation problems, including heart onslaught or stroke. This risk will magnify the longer you use ketorolac. Do not use this medication just till or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

• Search abnormal medical help if you have symptoms of heart or circulation problems, such as chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.

• This medication can also magnify your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking ketorolac. Older adults may have an even greater risk of these serious gastrointestinal side effects.

• Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

• Do not drink alcohol while taking ketorolac. Alcohol can magnify the risk of stomach bleeding caused by ketorolac.

What is ketorolac?

• Ketorolac is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Ketorolac works by reducing hormones that reason inflammation and pain in the body.

• Ketorolac is used short-term (5 days or less) to treat temperate to severe pain.

• Ketorolac may also be used for another purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking ketorolac?

• Do not use this medicine if you are allergic to ketorolac, aspirin, or another NSAIDs, or if you have:

· severe kidney disease;

· a bleeding or blood clotting disorder;

· a closed head injury or bleeding in your brain;

· a stomach ulcer or a history of stomach or intestinal bleeding; or

· if you are breast-feeding a baby.

• Do not take ketorolac if you are also taking pentoxifylline (Trental) or probenecid (Benemid). Do not take ketorolac with aspirin or another NSAIDs such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), or piroxicam (Feldene).

• Taking an NSAID can magnify your risk of life-threatening heart or circulation problems, including heart onslaught or stroke. This risk will magnify the longer you use an NSAID. Do not use this medication just till or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

• NSAIDs can also magnify your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking an NSAID. Older adults may have an even greater risk of these serious gastrointestinal side effects.

• Till taking ketorolac, speak your doctor if you are allergic to any drugs, or if you have:

· a history of heart onslaught, stroke, or blood clot;

· heart malady, congestive heart failure, tall blood pressure;

· liver or kidney disease,

· ulcerative colitis or Crohn's disease;

· asthma;

· polyps in your nose;

· if you have recently had surgery; or

· if you smoke.

• If you have any of these conditions, you may need a doze adjustment or particular trials to safely take ketorolac.

• FDA pregnancy category C. This medicine may be deleterious to an unborn child. Speak your doctor if you are pregnant or plan to become pregnant during treatment. Taking ketorolac during labor can magnify the risk of bleeding during childbirth. Do not take ketorolac during pregnancy unless your doctor has told you to.

• This medicine can affect fertility (your capacity to have children). Do not take ketorolac while you are trying to get pregnant.

• Ketorolac can pass into breast milk and may harm a nursing child. Do not take this medication without telling your doctor if you are breast-feeding a baby.

• Do not give this medication to anyone younger than 18 years old.

How must I take ketorolac?

• Take this medicine exactly as it was predesigned for you. Do not take the medicine in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label. Ketorolac is not for treating minor aches and pains.

• Ketorolac is generally given first as an injection, and then as an oral (by mouth) medication. Ketorolac injection is given through a needle into a muscle or a vein. Your doctor, nurse, or another healthcare provider will give you this injection.

• The ketorolac tablet must be taken with a full glass of water.

• Ketorolac is normally given for 5 days or smaller, including both the injection and oral forms combined. Long-term use of ketorolac can hurt your kidneys or reason bleeding.

• If you need to have any type of surgery, speak the surgeon onward of time if you have recently used ketorolac.

• Store ketorolac tablets at room temperature away from moisture and heat.

What happens if I miss a dose?

• Since ketorolac is taken as needed for pain, you may not be on a dosing schedule. And if you receive ketorolac injection in a hospital setting, it is not likely that you will miss a dose.

• If you are taking the medicine regularly, take the missed doze as soon as you remember. If it is nearly time for your following doze, skip the missed doze and take the medication at your following regularly scheduled time. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention if you think you have used too many of this medicine.

• Overdose symptoms may include nausea, vomiting, stomach pain, drowsiness, black or bloody stools, coughing up blood, urinating smaller than normal, shallow breathing, and fainting.

What must I avoid while taking ketorolac?

• Do not use any another over-the-counter cool, allergy, or pain medicine without first asking your doctor or pharmacist. Much medicines accessible over the counter contain aspirin or another medicines similar to ketorolac (such as ibuprofen, ketoprofen, or naproxen). If you take determined commodity together you may accidentally take too many of this type of medicine. Read the label of any another medication you are using to see if it contains aspirin, ibuprofen, ketoprofen, or naproxen.

• Do not drink alcohol while taking ketorolac. Alcohol can magnify the risk of stomach bleeding caused by ketorolac.

What are the possible side effects of ketorolac?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Stop taking ketorolac and search medical attention or call your doctor at once if you have any of these serious side effects:

· chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;

· black, bloody, or tarry stools;

· coughing up blood or vomit that looks like coffee grounds;

· swelling or rapid weight gain;

· urinating smaller than normal or not at all;

· nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

· fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;

· the first sign of any mouth sores or skin rash, no matter how mild;

· pale skin, light bruising, severe tingling, numbness, pain, muscle weakness; or

· fever, headache, neck stiffness, chills, heighten sensitivity to easy, purple spots on the skin, and/or seizure (convulsions).

• Smaller serious side effects may include:

· upset stomach, mild nausea or vomiting, diarrhea, constipation;

· mild heartburn, stomach pain, bloating, gas;

· dizziness, headache, drowsiness;

· sweating; or

· ringing in your ears.

• This is not a complete list of side effects and others may occur. Speak your doctor about any unusual or bothersome side effect. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect ketorolac?

• Speak your doctor if you are taking an antidepressant such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor). Taking any of these drugs with ketorolac may reason you to bruise or bleed easily.

• Till taking ketorolac, speak your doctor if you are taking any of the next drugs:

· a blood thinner such as warfarin (Coumadin);

· lithium (Eskalith, Lithobid);

· methotrexate (Rheumatrex, Trexall);

· thiothixene (Navane);

· alprazolam (Xanax);

· diuretics (water pills) such as furosemide (Lasix);

· muscle relaxers;

· steroids (prednisone and others);

· seizure medications such as carbamazepine (Carbatrol, Tegretol) or phenytoin (Dilantin);

· a heart or blood pressure medicine such as candesartan (Atacand), eprosartan (Teveten), irbesartan (Avapro, Avalide), losartan (Cozaar, Hyzaar), valsartan (Diovan), telmisartan (Micardis), or olmesartan (Benicar); or

· aspirin or another NSAIDs such as etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Naprosyn), piroxicam (Feldene), and others; or

· an ACE inhibitor such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), ramipril (Altace), and others.

• This list is not complete and there may be another drugs that can interact with ketorolac. Speak your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal commodity, and drugs predesigned by another doctors. Do not start using a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about ketorolac.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.