IMMUNE GLOBULIN (INTRAVENOUS) (IGIV)

(im MYOON GLOB yoo lin) Brand: Carimune, Flebogamma, Gammagard (obsolete), Gammagard S/D, Gammaplex, Gammar-P I.V., Gamunex, Polygam S/D, Privigen, Sandoglobulin

What is the most significant information I must know about immune globulin?

• Immune globulin can harm your kidneys, and this effect is heighten when you also use determined another medicines deleterious to the kidneys. Till using immune globulin, speak your doctor about all another medications you use. Much another drugs (including some over-the-counter medicines) can be deleterious to the kidneys.

• Till using immune globulin intravenous, speak your doctor if you have kidney malady, diabetes (especially if you use insulin), a history of stroke or blood clot, heart malady, tall blood pressure, a condition called paraproteinemia, or if you are over 65 years old.

• To be certain this medication is helping your condition and is not causing deleterious effects, your blood will need to be tested often. Your kidney function may also need to be tested. Visit your doctor regularly.

• This medicine can reason unusual results with determined blood glucose trials. Speak any doctor who treats you that you are using immune globulin.

• Immune globulin is made from human plasma (part of the blood) which may contain viruses and another infectious agents. Donated plasma is tested and treated to reduce the risk of it containing infectious agents, but there is still a little possibility it could transmit malady. Conversation with your doctor about the risks and benefits of using this medication.

What is immune globulin intravenous (IVIG)?

• Immune globulin intravenous is a sterilized solution made from human plasma. It contains the antibodies to help your body protect itself against infection from different diseases.

• Immune globulin is used to treat primary immune deficiency, and to reduce the risk of infection in individuals with poorly functioning immune systems such as those with chronic lymphocytic leukemia (CLL). IGIV is also used to magnify platelets (blood clotting cells) in people with idiopathic thrombocytopenic purpura (ITP) and to prevent aneurysm caused by a weakening of the main artery in the heart associated with Kawasaki syndrome.

• Immune globulin is also used to treat chronic inflammatory demyelinating polyneuropathy (CIDP), a debilitating nerve mess that causes muscle weakness and can affect daily activities.

• Immune globulin may also be used for purposes not listed in this medicine guide.

What must I discuss with my health care provider till using immune globulin?

• You must not use this medicine if you have ever had an allergic reaction to an immune globulin or if you have immune globulin A (IgA) deficiency with antibody to IgA.

• To create certain you can safely use immune globulin, speak your doctor if you have any of these another conditions:

· kidney disease;

· diabetes (especially if you use insulin);

· a history of stroke or blood clot;

· heart malady or tall blood pressure;

· a condition called paraproteinemia; or

· if you are over 65 years old.

• FDA pregnancy category C. It is not known whether immune globulin will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.

• It is not known if immune globulin passes into breast milk or if it could harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

How is immune globulin intravenous given?

• Immune globulin intravenous is injected into a vein through an IV. You may be shown how to use an IV at house. Do not self-inject this medication if you do not fully understand how to give the injection and properly dispose of used needles, IV tubing, and another items used to inject the medicine.

• IVIG must not be injected into a muscle or under the skin.

• Do not use the medicine if it has changed colors or has particles in it. Call your doctor for a new prescription. Throw away any unused medication that is left over after injecting your dose.

• Use every disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Hold this container out of the reach of children and pets.

• IVIG is generally given each 3 to 4 weeks. Your dosing schedule may be various. Follow your doctor's instructions.

• Your doctor may occasionally change your doze to create certain you get the excellent results.

• This medicine can reason unusual results with determined blood glucose trials. Speak any doctor who treats you that you are using immune globulin.

• Some brands of immune globulin must be stored in a refrigerator, while others can be kept at room temperature. Follow the directions on your prescription label or ask your pharmacist if you have questions about how to store the medicine. Do not let the medication to freeze.

What happens if I miss a dose?

• Call your doctor for instructions if you miss a doze of this medication.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

What must I avoid while using immune globulin?

• Do not receive a "live" vaccine while using IVIG. The vaccine may not work as well during this time, and may not fully protect you from malady. Live vaccines include measles, mumps, rubella (MMR), Bacillus Calmette-Guérin (BCG), oral polio, rotavirus, smallpox, typhoid, yellow fever, varicella (chickenpox), H1N1 influenza, and nasal flu vaccine.

What are the possible side effects of immune globulin?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Call your doctor at once if you have a serious side effect such as:

· urinating smaller than normal or not at all;

· drowsiness, confusion, mood changes, heighten thirst, loss of appetite, nausea and vomiting;

· swelling, weight gain, feeling short of breath;

· wheezing, chest tightness;

· feeling like you might pass out;

· light bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;

· black or tarry stools, coughing up blood or vomit that looks like coffee grounds;

· red or pink urine;

· sudden numbness or weakness, sudden severe headache, confusion, problems with vision or speech;

· chest pain, sudden cough, wheezing, rapid breathing, warmth or swelling in one or both legs;

· fever with headache, neck stiffness, chills, heighten sensitivity to easy, purple spots on the skin, and/or seizure (convulsions); or

· pale or yellowed skin, dark colored urine, fever, confusion or weakness.

• Smaller serious side effects may include:

· mild headache;

· dizziness;

· weary feeling;

· back pain, muscle cramps;

· minor chest pain; or

· flushing (warmth, redness, or tingly feeling).

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect immune globulin?

• Immune globulin can harm your kidneys. This effect is heighten when you also use another medicines deleterious to the kidneys. You may need doze adjustments or particular trials if you have recently used:

· lithium (Lithobid);

· methotrexate (Rheumatrex, Trexall);

· pain or arthritis medicines such as aspirin (Anacin, Excedrin), acetaminophen (Tylenol), ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others;

· medicines used to treat ulcerative colitis, such as mesalamine (Pentasa) or sulfasalazine (Azulfidine);

· medicines used to prevent organ transplant rejection, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune) or tacrolimus (Prograf);

· IV antibiotics such as amphotericin B (Amphotec, AmBisome, Abelcet), amikacin (Amikin), bacitracin (Baci IM), capreomycin (Capastat), gentamicin (Garamycin), kanamycin (Kantrex), streptomycin, or vancomycin (Vancocin, Vancoled);

· antiviral medicines such as acyclovir (Zovirax), adefovir (Hepsera), cidofovir (Vistide), foscarnet (Foscavir), ganciclovir (Cytovene), valacyclovir (Valtrex), or valganciclovir (Valcyte); or

· cancer medication such as aldesleukin (Proleukin), carmustine (BiCNU, Gliadel), cisplatin (Platinol), ifosfamide (Ifex), oxaliplatin (Eloxatin), streptozocin (Zanosar), or tretinoin (Vesanoid).

• This list is not complete and another drugs may interact with immune globulin. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about immune globulin intravenous.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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