GADOPENTETATE DIMEGLUMINE

(gad oh PEN te tate paint MEG loo meen) Brand: Magnevist

What is the most significant information I must know about gadopentetate dimeglumine?

Gadopentetate dimeglumine can reason a life-threatening condition in people with advanced kidney malady. The symptoms of this condition include:

· burning, itching, swelling, scaling, and tightening or hardening of your skin;

· muscle weakness;

· joint stiffness in your arms, hands, legs, or feet;

· deep bone pain in your ribs or your hips;

· trouble moving; or

· skin redness or discoloration.

• Till receiving this medication, speak your doctor if you have kidney malady or if you are on dialysis. You may not be able to receive gadopentetate dimeglumine. Also speak your doctor if you have recently received any contrast agent similar to gadopentetate dimeglumine.

• Also speak your doctor if you have diabetes, tall blood pressure, liver malady, a heart rhythm mess, asthma or allergies, if you are over 60 years old, if you have ever had a reaction to a contrast agent, or if you have recently had an injury, surgery, or severe infection.

• Your doctor or another healthcare provider may want to watch you for a short time after your test is over. This is to create certain you do not have any unwanted side effects or delayed reactions.

What is gadopentetate dimeglumine?

Gadopentetate dimeglumine is a contrast agent that produces magnetic effects. It is used in combination with magnetic resonance imaging (MRI) to let blood vessels, organs, and another non-bony tissues to be seen more clearly on the MRI.

Gadopentetate dimeglumine is used to help diagnose determined disorders of the brain, blood vessels, and spin (central nervous system).

Gadopentetate dimeglumine may also be used for purposes not listed in this medicine guide.

What must I discuss with my health care provider till receiving gadopentetate dimeglumine?

Gadopentetate dimeglumine can reason a life-threatening condition in people with advanced kidney malady. The symptoms of this condition include:

· burning, itching, swelling, scaling, and tightening or hardening of your skin;

· muscle weakness;

· joint stiffness in your arms, hands, legs, or feet;

· deep bone pain in your ribs or your hips;

· trouble moving; or

· skin redness or discoloration.

• Till receiving this medication, speak your doctor if you have kidney malady or if you are on dialysis. You may not be able to receive gadopentetate dimeglumine. Also speak your doctor if you have recently received any contrast agent similar to gadopentetate dimeglumine

• To create certain you can safely receive this medicine, speak your doctor if you have any of these another conditions:

· diabetes;

· tall blood pressure;

· liver disease;

· a heart rhythm disorder;

· asthma, hay fever, or a history of food or drug allergies;

· if you are over 60 years old;

· if you have ever had any type of reaction to a contrast agent; or

· if you have recently had an injury, surgery, or severe infection.

• FDA pregnancy category C. It is not known whether gadopentetate dimeglumine will harm an unborn child. Till you receive this medicine, speak your doctor if you are pregnant.

Gadopentetate dimeglumine can pass into breast milk and may harm a nursing child. Till you receive this medicine, speak your doctor if you are breast-feeding a baby.

How is gadopentetate dimeglumine used?

Gadopentetate dimeglumine is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting during your MRI.

• Your doctor or another healthcare provider may want to watch you for a short time after your test is over. This is to create certain you do not have any unwanted side effects or delayed reactions.

What happens if I miss a dose?

• Since gadopentetate dimeglumine is used only during your MRI, you will not be on a dosing schedule.

What happens if I overdose?

• Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What must I avoid after receiving gadopentetate dimeglumine?

• Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of gadopentetate dimeglumine?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Speak your caregivers at once if you have a serious side effect such as:

· urinating smaller than normal or not at all;

· drowsiness, confusion, mood changes, heighten thirst, loss of appetite;

· swelling, weight gain, feeling short of breath; or

· swelling, bruising, redness, itching, burning, or skin changes where the injection was given.

• Smaller serious side effects may include:

· headache, dizziness;

· nausea;

· feeling unusually hot;

· unusual or unpleasant taste in your mouth;

· flushing (warmth, redness, or tingly feeling);

· numbness; or

· cool feeling, warmth, pain, or burning where the medication was injected.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect gadopentetate dimeglumine?

• This medicine can harm the kidneys in determined people, and this effect may be heighten if you also use another medicines deleterious to the kidneys. Much another drugs (including some over-the-counter medicines) can harm your kidneys. You may need doze adjustments or particular trials if you have recently used any of these medications, such as:

· lithium (Eskalith, Lithobid);

· methotrexate (Rheumatrex, Trexall);

· pain or arthritis medicines such as aspirin (Anacin, Excedrin), acetaminophen (Tylenol), ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others;

· medicines used to treat ulcerative colitis, such as mesalamine (Pentasa) or sulfasalazine (Azulfidine);

· medicines used to prevent organ transplant rejection, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune) or tacrolimus (Prograf);

· IV antibiotics such as amphotericin B (Amphotec, AmBisome, Abelcet), amikacin (Amikin), bacitracin (Baci IM), capreomycin (Capastat), gentamicin (Garamycin), kanamycin (Kantrex), streptomycin, or vancomycin (Vancocin, Vancoled);

· antiviral medicines such as acyclovir (Zovirax), adefovir (Hepsera), cidofovir (Vistide), foscarnet (Foscavir), ganciclovir (Cytovene), valacyclovir (Valtrex), or valganciclovir (Valcyte); or

· cancer medication such as aldesleukin (Proleukin), carmustine (BiCNU, Gliadel), cisplatin (Platinol), ifosfamide (Ifex), oxaliplatin (Eloxatin), streptozocin (Zanosar), or tretinoin (Vesanoid).

• There may be another drugs that can affect gadopentetate dimeglumine. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your doctor or pharmacist can provide more information about gadopentetate dimeglumine.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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