(PRAM lin tide) Brand: Symlin, SymlinPen 120, SymlinPen 60
• Do not mix pramlintide and insulin together in the same syringe.
• You will need to use a lower doze of insulin than you used till you started using pramlintide. Your doctor will determine your correct dose.
• Call your doctor if you have severe nausea that lasts for different days. This may be a sign that your doze is too high.
• If you skip a meal, do not take your doze of pramlintide. Wait before your following meal.
• If you stop using pramlintide for a short time, you may need to restart the medicine at a lower doze. Do not change your doses or medicine schedule without your doctor's advice.
• Take care not to allow your blood sugar get too low, causing hypoglycemia. Severe hypoglycemia may occur within 3 hours after your pramlintide injection. Carry heavy candy or glucose tablets with you in case you have low blood sugar. Be certain your family and close friends know how to help you in an emergency.
• Pramlintide is a man-made form of a hormone that occurs naturally in the body. Pramlintide lowers blood sugar in three ways. It slows the course that food moves from your stomach to your intestines, which keeps your blood sugar from rising too quick. Pramlintide also lowers the amount of glucose (sugar) your liver produces. Lastly, pramlintide triggers the feeling of fullness after meals to help control your appetite and decrease how many food you eat.
• Pramlintide is used together with insulin to treat type 1 or type 2 diabetes.
• Pramlintide may also be used for another purposes not listed in this medicine guide.
• Do not use this medicine if you are allergic to pramlintide or metacresol. Do not use if you have a digestive condition called "delayed gastric emptying," or if you can't recognize symptoms of low blood sugar.
• If you have any of these another conditions, you may need a pramlintide doze adjustment or particular tests:
· a history of delayed gastric emptying;
· if you are unable to check your blood sugars regularly up to different times daily;
· if you have had severe hypoglycemia more than once in the past 6 months;
• FDA pregnancy category C. It is not known whether pramlintide will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medication..
• It is not known whether pramlintide passes into breast milk or if it could harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.
• Pramlintide must not be used in children.
• Use pramlintide exactly as it was predesigned for you. Do not use the medicine in larger or less amounts, or use it for longer than recommended by your doctor. You may not be able to hold using pramlintide if you do not follow the dosing instructions.
• Pramlintide is injected under the skin, at the same time as your insulin injection but in a separate syringe or injector pen. Do not self-inject this medication if you do not fully understand how to give the injection and properly dispose of used needles and syringes. Do not mix pramlintide and insulin together in the same syringe.
• Use only the syringe or injection pen recommended by your doctor. Ask your pharmacist about which needles to buy for proper use of the syringe or injection pen.
• Pramlintide is generally given just till every major meal. Follow your doctor's instructions. If you skip a meal, do not take your doze of pramlintide. Wait before your following meal.
• Pramlintide must be at room temperature when you inject it.
• Use a various seat on your stomach or thigh every time you give the injection. Inject your insulin in a separate skin area. Do not inject insulin or pramlintide into the same seat two times in a row. Do not use the medicine if it has changed colors or has particles in it. Call your doctor for a new prescription.
• Use a disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Hold this container out of the reach of children and pets.
• Call your doctor if you have severe nausea that lasts for different days. This may be a sign that your doze is too high.
• If you stop using pramlintide for a short time, you may need to restart the medicine at a lower doze. Follow your doctor's instructions.
• You will need to use a lower doze of insulin than you used till you started using pramlintide. Your doctor will determine the correct insulin doze based on the type of diabetes you have.
• Do not change your doses or medicine schedule without your doctor's advice. Your blood sugar will need to be checked often, and you may need another blood trials at your doctor's office. Visit your doctor regularly.
• Take care not to allow your blood sugar get too low, causing hypoglycemia. Severe hypoglycemia may occur within 3 hours after your pramlintide injection. Symptoms include headache, famine, sweating, tremor, irritability, or trouble concentrating. Carry heavy candy or glucose tablets with you in case you have low blood sugar. Be certain your family and close friends know how to help you in an emergency.
• Severe hypoglycemia may reason loss of consciousness, seizures, or death. If you have severe hypoglycemia and can't ate or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon abnormal injection kit and speak you how to give the injection.
• Storing unopened vials or injection pens: Hold in the carton and store in a refrigerator, protected from easy. Throw away any insulin not used till the expiration date on the medication label.
• Do not freeze pramlintide, and throw away the medicine if it has become frozen.
• Storing after your first use: You may hold "in-use" vials or injection pens in the refrigerator or at room temperature. Use within 30 days.
• Take the missed doze as soon as you remember, but only if you are getting ready to ate a meal. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.
• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222. Overdose may reason diarrhea, vomiting, dizziness, cool sweats, warmth or tingly feeling.
• Do not remove pramlintide from an injector pen and put it in a syringe. You may receive too tall a dose.
• Avoid drinking alcohol. It can lower your blood sugar.
• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.
• Call your doctor at once if you have any of these serious side effects:
· severe nausea that lasts for 3 to 7 days; or
· more frequent tall blood sugar levels.
• Smaller serious side effects may include:
· runny or stuffy nose, sore throat, cough;
· nausea, loss of appetite;
· headache, weary feeling; or
· joint pain.
• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.
• The next drugs can interact with pramlintide. Speak your doctor if you are using any of these:
· acarbose (Precose) or miglitol (Glyset);
· disopyramide (Norpace);
· fluoxetine (Luvox);
· pentoxyfylline (Trental);
· propoxyphene (Darvon, Darovcet);
· diabetes medications you take by mouth;
· atropine (Atreza, Sal-Tropine), dicyclomine (Bentyl), hyoscyamine (Hyomax), oxybutynin (Ditropan, Oxytrol);
· an ACE inhibitor such as benazepril (Lotensin), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), quinapril (Accupril), ramipril (Altace), and others; or
· cholesterol-lowering medicine such as fenofibrate (Lofibra, Fenoglide, TriCor, Lipofen) or gemfibrozil (Lopid).
• Using certain medicines can create it harder for you to speak when you have low blood sugar. Speak your doctor if you use any of the following:
· albuterol (Proventil, Ventolin);
· clonidine (Catapres); or
· a beta-blocker such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others.
• You may be more likely to have tall or low blood sugar if you are using pramlintide with other drugs that raise or lower blood sugar. This includes:
· isoniazid;
· probenecid (Benemid);
· aspirin or another salicylates (including Pepto-Bismol);
· birth control pills and another hormones;
· diet pills or medicines to treat asthma, colds or allergies;
· diuretics (water pills);
· a monoamine oxidase inhibitor (MAOI);
· phenothiazines (Compazine and others);
· steroids (prednisone and others);
· seizure medicines (Dilantin and others);
· some nonsteroidal anti-inflammatory drugs (NSAIDs); and
· sulfa drugs (Bactrim, Gantanol, Gantrisin, Septra, SMX-TMP, and others).
• These lists are not complete and another drugs may interact with pramlintide. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.
• Your pharmacist can provide more information about pramlintide.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.