GLIPIZIDE AND METFORMIN
(GLIP ih zyd and met FOR min) Brand: Metaglip
What is the most significant information I must know about glipizide and metformin?
• Do not use glipizide and metformin if you have congestive heart failure or kidney malady, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).
• If you need to have any type of x-ray or CT scan using a paint that is injected into your veins, you will need to temporarily stop taking glipizide and metformin.
• Take care not to allow your blood sugar get too low. Low blood sugar (hypoglycemia) can occur if you skip a meal, exercice too long, drink alcohol, or are under stress. Symptoms include headache, famine, weakness, sweating, tremor, irritability, or trouble concentrating. Carry heavy candy or glucose tablets with you in case you have low blood sugar. Another sugar sources include orange juice and milk. Be certain your family and close friends know how to help you in an emergency.
• Some people develop lactic acidosis while taking metformin. Early symptoms may get worse over time and this condition can be fatal. Get abnormal medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cool feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart course, dizziness, or feeling very weak or tired.
What is glipizide and metformin?
• Glipizide and metformin is a combination of two oral diabetes medicines that help control blood sugar levels.
• Glipizide and metformin is for people with type 2 diabetes who do not use daily insulin injections. This medicine is not for treating type 1 diabetes.
• Glipizide and metformin may also be used for purposes not listed in this medicine guide.
What must I discuss with my healthcare provider till taking glipizide and metformin?
• Do not use glipizide and metformin if you have congestive heart failure or kidney malady, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).
• If you need to have any type of x-ray or CT scan using a paint that is injected into your veins, you will need to temporarily stop taking glipizide and metformin.
• To create certain you can safely take this medicine, speak your doctor if you have any of these another conditions:
· liver disease;
· a history of heart onslaught or stroke; or
· if you are over 80 years old and have not recently had your kidney function checked.
• Some people develop a life-threatening condition called lactic acidosis while taking metformin. You may be more likely to develop lactic acidosis if you have liver or kidney malady, congestive heart failure, a severe infection, if you are dehydrated, or if you drink big amounts of alcohol. Conversation with your doctor about your individual risk.
• FDA pregnancy category C. It is not known whether glipizide and metformin will harm an unborn child. Similar diabetes medications have caused severe hypoglycemia in newborn babies whose mothers had used the medicine around the time of delivery. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.
• It is not known whether glipizide and metformin passes into breast milk or if it could harm a nursing child. You must not breast-feed while you are taking this medication.
How must I take glipizide and metformin?
• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.
• Take glipizide and metformin with meals.
• Your blood sugar will need to be checked often, and you may need another blood trials at your doctor's office. Visit your doctor regularly.
• Know the signs of low blood sugar (hypoglycemia) and how to recognize them: headache, famine, weakness, sweating, tremor, irritability, or trouble concentrating.
• Always hold a source of sugar accessible in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. If you have severe hypoglycemia and can't ate or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon abnormal injection kit and speak you how to give the injection.
• Check your blood sugar carefully during a time of stress or diseases, if you travel, exercice more than normal, drink alcohol, or skip meals. These things can affect your glucose levels and your doze needs may also change.
• Your doctor may want you to stop taking this medicine for a short time if you become ill, have a fever or infection, or if you have surgery or a medical emergency.
• Ask your doctor how to adjust your doze if needed. Do not change your medicine doze or schedule without your doctor's advice.
• Your doctor may have you take extra vitamin B12 while you are taking glipizide and metformin. Take only the amount of vitamin B12 that your doctor has prescribed.
• Glipizide and metformin is only part of a complete program of treatment that also includes diet, exercice, and weight control. It is significant to use this medication regularly to get the most benefit. Get your prescription refilled till you run out of medication completely.
• Store at room temperature away from moisture and heat.
What happens if I miss a dose?
• Take the missed doze as soon as you remember (be certain to take the medication with food). Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.
What happens if I overdose?
• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.
• Overdose may reason lactic acidosis. Get abnormal medical help if you have any of these symptoms of lactic acidosis: muscle pain or weakness, numb or cool feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart course, dizziness, or feeling very weak or tired.
• You may also have symptoms of severe hypoglycemia: extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).
What must I avoid while taking glipizide and metformin?
• Avoid drinking alcohol. It lowers blood sugar and may magnify your risk of lactic acidosis.
What are the possible side effects of glipizide and metformin?
• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.
• This medicine may reason lactic acidosis (a build-up of lactic acid in the body, which can be fatal). Lactic acidosis can start slowly and get worse over time. Get abnormal medical help if you have even mild symptoms of lactic acidosis, such as: muscle pain or weakness, numb or cool feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart course, dizziness, or feeling very weak or tired.
• Stop taking this medicine and call your doctor at once if you have a serious side effect such as:
· feeling short of breath, even with mild exertion, swelling or rapid weight gain;
· pain or burning with urination;
· nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
· dangerously tall blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).
• Smaller serious side effects may include:
· cool symptoms such as stuffy nose, sneezing, sore throat;
· headache, dizziness;
· mild nausea, vomiting, diarrhea, stomach pain; or
· joint or muscle pain.
• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.
What another drugs will affect glipizide and metformin?
• You may be more likely to have hyperglycemia (high blood sugar) if you take this medicine with another drugs that can raise blood sugar, such as:
· isoniazid;
· diuretics (water pills);
· steroids (prednisone and others);
· heart or blood pressure medicine (Cartia, Cardizem, Covera, Isoptin, Verelan, and others);
· niacin (Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others);
· phenothiazines (Compazine and others);
· thyroid medication (Synthroid and others);
· birth control pills and another hormones;
· seizure medicines (Dilantin and others); and
· diet pills or medicines to treat asthma, colds or allergies.
• You may be more likely to have hypoglycemia (low blood sugar) if you take another drugs that can lower blood sugar, such as:
· exenatide (Byetta);
· probenecid (Benemid);
· some nonsteroidal anti-inflammatory drugs (NSAIDs);
· aspirin or another salicylates (including Pepto-Bismol);
· sulfa drugs (Bactrim and others);
· a monoamine oxidase inhibitor (MAOI);
· beta-blockers (Tenormin and others); or
· another diabetes medications, especially acarbose (Precose), metformin (Glucophage), miglitol (Glyset), pioglitazone (Actos), or rosiglitazone (Avandia).
• Speak your doctor about all another medicines you use, especially:
· furosemide (Lasix);
· nifedipine (Adalat, Procardia);
· cimetidine (Tagamet) or ranitidine (Zantac);
· amiloride (Midamor) or triamterene (Dyrenium);
· digoxin (Lanoxin);
· morphine (MS Contin, Kadian, Oramorph);
· procainamide (Procan, Pronestyl, Procanbid);
· quinidine (Quin-G);
· trimethoprim (Proloprim, Primsol, Bactrim, Cotrim, Septra);
· vancomycin (Vancocin, Lyphocin); or
· ketoconazole (Nizoral), itraconazole (Sporanox).
• These lists are not complete and there are much another medicines that can magnify or decrease the effects of glipizide and metformin on lowering your blood sugar. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.
Where can I get more information?
• Your pharmacist can provide more information about glipizide and metformin.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
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