FAMOTIDINE AND IBUPROFEN

(fam OH ti deen and EYE bue PROE fen) Brand: Duexis

What is the most significant information I must know about famotidine and ibuprofen?

• You must not use this medicine if you are allergic to ibuprofen (Advil, Motrin), famotidine (Pepcid), aspirin, another NSAIDs (non-steroidal anti-inflammatory drugs), or another stomach acid reducers (such as Tagamet, Zantac, or Axid).

• Do not use famotidine and ibuprofen if you are more than 29 weeks (7 months) pregnant. Taking ibuprofen during this time may harm the unborn baby.

• Till you take this medication, speak your doctor if you have a stomach or intestinal mess, heart malady, tall blood pressure, asthma, nasal polyps, liver or kidney malady, lupus, a bleeding or blood-clotting mess, or a history of heart onslaught, stroke, or blood clot. Also speak your doctor if you smoke.

• Ibuprofen may reason life-threatening heart or circulation problems such as heart onslaught or stroke, especially if you use it long term. Do not use famotidine and ibuprofen just till or after heart bypass surgery (coronary artery bypass graft, or CABG).

• Get abnormal medical help if you have chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.

• Ibuprofen may also reason serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning, especially in older adults.

• Call your doctor at once if you have symptoms of stomach bleeding such as black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

What is famotidine and ibuprofen?

• Famotidine is a histamine blocker. Famotidine works by decreasing the amount of acid the stomach produces.

• Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). Ibuprofen works by reducing hormones that reason inflammation and pain in the body.

• Famotidine and ibuprofen is a combination drug. Ibuprofen treats the symptoms of arthritis. Famotidine helps reduce the risk of ulcers in the stomach or intestines that can be caused by long-term use of ibuprofen.

• Famotidine and ibuprofen may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking famotidine and ibuprofen?

• Do not use famotidine and ibuprofen just till or after heart bypass surgery (coronary artery bypass graft, or CABG).

• Ibuprofen may reason life-threatening heart or circulation problems such as heart onslaught or stroke, especially if you use it long term.

• You must not use this medicine if you are allergic to ibuprofen (Advil, Motrin) or famotidine (Pepcid), or if you have:

· a history of asthma, hives, or severe allergic reaction after taking aspirin or other NSAID, such as naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others;

· if you are allergic to another stomach acid reducers such as ranitidine (Zantac), cimetidine (Tagamet), or nizatidine (Axid); or

· if you are more than 29 weeks (7 months) pregnant.

• To create certain you can safely take famotidine and ibuprofen, speak your doctor if you have any of these another conditions:

· Crohn's malady, inflammatory bowel malady, or ulcerative colitis;

· a history of heart onslaught, stroke, or blood clot;

· heart malady, congestive heart failure, tall blood pressure;

· a history of stomach ulcers or bleeding;

· asthma;

· polyps in your nose;

· liver or kidney disease;

· systemic lupus erythematosus (SLE);

· a bleeding or blood clotting mess; or

· if you smoke.

• Famotidine and ibuprofen can pass into breast milk and may harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

• FDA pregnancy category C. Do not take this medication if you are more than 7 months pregnant. Taking ibuprofen during this time may harm the unborn baby. Speak your doctor if you are pregnant or plan to become pregnant while using famotidine and ibuprofen.

• Do not give this medication to a baby without the advice of a doctor.

How must I take famotidine and ibuprofen?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.

• Famotidine and ibuprofen is generally taken 3 times every day. Follow your doctor's instructions.

• Do not take more of this medicine than is recommended. An overdose of ibuprofen can reason hurt to your stomach or intestines. The maximum amount of ibuprofen for adults is 800 milligrams for doze or 3200 mg for day (4 maximum doses). Use only the smallest amount of ibuprofen needed to get relief from your pain, swelling, or fever.

• Do not crush, chew, or interrupt a famotidine and ibuprofen tablet. Swallow it intact.

• If you have hypertension, your blood pressure will need to be checked often. If you use this medicine long-term, your doctor may want to check you on a regular basis to create certain this medicine is not causing deleterious effects. Visit your doctor regularly.

• If you also use a steroid medicine, do not stop using it suddenly or you may have unpleasant withdrawal symptoms. Conversation with your doctor about using smaller and smaller of the steroid till stopping completely.

• Store at room temperature away from moisture and heat. Hold the bottle tightly closed when not in use.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose symptoms may include severe dizziness, rapid back and forth eye movements, pale skin and blue lips or fingernails, and fainting.

What must I avoid while taking famotidine and ibuprofen?

• Avoid using another medications that contain ibuprofen.

• Ask a doctor or pharmacist till using any another cool, allergy, or pain medication. Ibuprofen and another NSAIDs are contained in much combination medicines. Taking determined commodity together can reason you to get too many ibuprofen. Check the label to see if a medication contains ibuprofen or similar NSAIDs (aspirin, naproxen, ketoprofen).

• Avoid drinking alcohol. It may magnify your risk of stomach bleeding.

What are the possible side effects of famotidine and ibuprofen?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Stop taking famotidine and ibuprofen and search medical attention or call your doctor at once if you have any of these serious side effects:

· sudden numbness or weakness, especially on one side of the body;

· sudden severe headache, confusion, problems with vision, speech, or balance;

· black, bloody, or tarry stools, coughing up blood or vomit that looks like coffee grounds;

· sweating, trouble breathing, chest pain or discomfort that may spread to the hand, shoulder, back, or jaw;

· feeling short of breath, even with mild exertion;

· swelling or rapid weight gain;

· urinating smaller than normal or not at all;

· nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

· severe skin reaction -- fever, sore throat, redness or swelling in your person, redness or swelling of your hands or foots, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the person or upper body) and causes blistering and peeling;

· pale skin, feeling light-headed or short of breath, rapid heart course, trouble concentrating;

· bruising, severe tingling, numbness, pain, muscle weakness; or

· severe headache, neck stiffness, chills, heighten sensitivity to easy, and/or seizure (convulsions).

• Smaller serious side effects may include:

· upset stomach, vomiting, diarrhea, constipation;

· bloating, gas;

· headache;

· throat irritation;

· blurred vision, changes in color vision; or

· mild back pain.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect famotidine and ibuprofen?

• Ask your doctor till using an antidepressant such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax), fluvoxamine (Luvox), paroxetine (Paxil), or sertraline (Zoloft). Taking any of these medicines with an NSAID may reason you to bruise or bleed easily.

• Speak your doctor about all another medicines you use, especially:

· cholestyramine (Prevalite, Questran);

· lithium (Eskalith, Lithobid);

· methotrexate (Rheumatrex, Trexall);

· a blood thinner such as warfarin (Coumadin, Jantoven).

· aspirin or another NSAIDs such as naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others;

· diuretics (water pills) such as furosemide (Lasix);

· heart or blood pressure medication such as benazepril (Lotensin), enalapril (Vasotec), lisinopril (Prinivil, Zestril), quinapril (Accupril), ramipril (Altace), and others; or

· steroids (oral, nasal, or inhaled).

• This list is not complete and another drugs may interact with famotidine and ibuprofen. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about famotidine and ibuprofen.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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