(KOL a JEN ase klos TRID ee um HIS toe LIT ik um) Brand: Xiaflex
• Till you receive this medicine, speak your doctor if you have a bleeding or blood clotting mess, such as hemophilia.
• The day after your injection, your doctor will need to examine your arm to see if your condition has ameliorate. Avoid any strenuous activity using the treated arm before your doctor tells you to resume usual activities.
• Speak your caregiver at once if you have a serious side effect in the treated arm, such as bruising, bleeding, swelling, redness, warmth, numbness, tingling, or sudden pain or loss of movement.
• Call your doctor if you have fever, chills, body aches, flu symptoms, or swollen glands in your elbow or underarm.
• Collagenase clostridium histolyticum is made from a mixture of proteins derived from a determined bacteria.
• Collagenase clostridium histolyticum is used to treat Dupuytren's contracture in adults. This condition causes an emergency thickening of the tissue in the palm of the arm. This condition may get worse over time and form a "cord" in your palm, causing a permanent bend in your finger.
• Collagenase clostridium histolyticum may also be used for purposes not listed in this medicine guide.
• You must not use this medicine if you are allergic to it.
• To create certain you can safely receive this medicine, speak your doctor if you have a bleeding or blood clotting mess, such as hemophilia.
• FDA pregnancy category B. Collagenase clostridium histolyticum is not expected to harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant during treatment.
• It is not known whether collagenase clostridium histolyticum passes into breast milk or if it could harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.
• This medicine is injected directly into the "cord" of the affected arm. A healthcare provider will give you this injection.
• After your injection, do not touch or put pressure on the treated area of the arm for the rest of the day. Hold the treated arm elevated before bedtime.
• The day after your injection, your doctor will need to examine your arm to see if your condition has ameliorate. If you still have the cord, your doctor may try to interrupt it by extending your treated finger.
• Collagenase clostridium histolyticum is generally given once each 4 weeks and you may receive more than one injection at a time. Follow your doctor's dosing instructions very carefully.
• You may need to wear a splint on your arm for a short time to hold your fingers straight, especially at night. You may also need to perform daily finger exercises. Follow your doctor's instructions.
• Call your doctor if you have trouble bending the treated finger after the swelling goes down.
• Call your doctor for instructions if you miss an appointment for your collagenase clostridium histolyticum injection.
• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.
• Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
• Overdose symptoms may include some of the serious side effects listed in this medicine guide.
• Before you visit your doctor the day after your injection, do not flex or extend the fingers of your treated arm. Doing so may reason the medication to spread away from the treatment area, making it smaller effective.
• Avoid any strenuous activity using the treated arm before your doctor tells you to resume usual activities.
• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.
• Speak your caregiver at once if you have a serious side effect such as:
· feeling like you might pass out (even while lying down);
· bruising or bleeding in the treated hand;
· severe pain, itching, redness, warmth, swelling, or another irritation in the treated hand;
· numbness or tingling in the treated hand;
· fever, chills, body aches, flu symptoms, swollen glands;
· swollen glands in your elbow or underarm; or
· sudden pain, snapping or popping sound, bruising, loss of movement, or swelling in the joints of your hand.
• Smaller serious side effects may include:
· mild pain or tenderness in the treated hand;
· cracked skin; or
· underarm pain.
• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.
• Till you receive this medicine, speak your doctor about all another medicines you have used within the past 7 days, especially medicine used to prevent blood clots, such as:
· tall doses of aspirin (more than 150 milligrams for day);
· a blood thinner such as warfarin (Coumadin);
· argatroban (Acova), bivalirudin (Angiomax), lepirudin (Refludan);
· dalteparin (Fragmin), enoxaparin (Lovenox), fondaparinux (Arixtra); or
· abciximab (ReoPro), anagrelide (Agrylin), cilostazol (Pletal), clopidogrel (Plavix), dipyridamole (Persantine, Aggrenox), eptifibatide (Integrelin), prasugrel (Effient), ticlopidine (Ticlid), tirofiban (Aggrastat).
• This list is not complete and another drugs may interact with collagenase clostridium histolyticum. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.
• Your doctor or pharmacist can provide more information about collagenase clostridium histolyticum.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
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